Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 458, 713-714 (9 April 2009) | doi:10.1038/458713a; Published online 8 April 2009
Open Innovation Challenges
-
Direct Molecular Detection of Proteins and Nucleic Acids
This Challenge is looking for novel approaches to protein and nucleic acid detection. This is an Id...
-
Methods of Modeling Adaptation in Populations
The analysis of adaptation with a population is a frequently encountered computational modeling scen...
- More Challenges
- Powered by:
nature jobs
Bioprocess Engineer
- Praj Matrix - Praj Industries Ltd
- Pune, Maharashtra Pune-411021 India
Postdoctoral Positions
- Johns Hopkins University
- Baltimore, Maryland, USA
Cancer: When restriction is good
Anne Brunet1
Abstract
Dietary restriction can prolong life and delay the onset of cancer. Suppressing the signalling pathway that is mediated by the hormone insulin might be crucial for the anticancer effects of reduced caloric intake.
It is well established that dietary restriction, which involves limiting nutrient intake below normal levels but without reaching malnutrition, extends lifespan in most, if not all, species — probably including humans1. This amazing benefit is likely to be due to the evolutionary advantage of keeping alive under suboptimal nutrient availability, and postponing reproduction until food is plentiful.
- Anne Brunet is in the Department of Genetics, Stanford University, Stanford, California 94305, USA.
Email: anne.brunet@stanford.edu
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Tumours with PI3K activation are resistant to dietary restrictionNature Article (09 Apr 2009)
Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegansNature Letters to Editor (05 Feb 2009)
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegansNature Article (31 May 2007)
