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Insight: Signalling in cancer

Vol. 441, No. 7092 pp423-457

Cancer

Thirty years of oncogene research have provided fascinating insights into the molecular basis of cancer. Many hurdles remain in the race to beat cancer, but as the articles in this Insight show, a growing understanding of the complex signalling pathways that underlie tumour formation and progression is driving the development of a new generation of anticancer drugs targeted at specific molecular events. All content is FREE ACCESS for 6 months.

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Editorial

Signalling in cancer

Alex Eccleston and Ritu Dhand

doi:10.1038/441423a


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Reviews

Ras, PI(3)K and mTOR signalling controls tumour cell growth

Reuben J. Shaw and Lewis C. Cantley

doi:10.1038/nature04869


Nuclear factor-κB in cancer development and progression

Michael Karin

doi:10.1038/nature04870


Hypoxia signalling in cancer and approaches to enforce tumour regression

Jacques Pouysségur, Frédéric Dayan and Nathalie M. Mazure

doi:10.1038/nature04871


New signals from the invasive front

Gerhard Christofori

doi:10.1038/nature04872


Validating cancer drug targets

John D. Benson, Ying-Nan P. Chen, Susan A. Cornell-Kennon, Marion Dorsch, Sunkyu Kim, Magdalena Leszczyniecka, William R. Sellers and Christoph Lengauer

doi:10.1038/nature04873


Mechanisms of drug inhibition of signalling molecules

Judith S. Sebolt-Leopold and Jessie M. English

doi:10.1038/nature04874