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Nature 458, 709-710 (9 April 2009) | doi:10.1038/458709a; Published online 8 April 2009
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Drug discovery: Fresh target for cancer therapy
Raymond J. Deshaies1
Abstract
The Byzantine system for degrading proteins inside cells is already the target of a successful anticancer drug. A compound that inhibits another part of this system also shows promise in models of cancer in mice.
Drug discovery is hard. Even harder is drug discovery aimed at biological systems that haven't previously been tested as therapeutic targets.
- Raymond J. Deshaies is in the Division of Biology and the Howard Hughes Medical Institute, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA.
Email: deshaies@its.caltech.edu
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