All cancers arise as a result of changes that have occurred in the DNA sequence of the genomes of cancer cells. Over the past quarter of a century much has been learnt about these mutations and the abnormal genes that operate in human cancers. We are now, however, moving into an era in which it will be possible to obtain the complete DNA sequence of large numbers of cancer genomes. These studies will provide us with a detailed and comprehensive perspective on how individual cancers have developed.

1. Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
2. Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK
3. Department of Haematology, University of Cambridge, Cambridge CB2 2XY, UK

Correspondence to: Michael R. Stratton^1,2 Correspondence and requests for materials should be addressed to M.R.S. (Email: mrs@sanger.ac.uk).

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