Featured
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Research Highlights |
Behavioural genetics: South bee-ch diet
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Editorial |
Testing time for gene patents
A surprising US court decision highlights the need to modernize gene-patenting practices if patients are to benefit from advances in genetic research.
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Letter |
Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease
Mutations in mitochondrial DNA (mtDNA) are a common cause of human genetic disease. It has been shown in non-human primates that nuclear transfer techniques might be an approach to prevent the transmission of mtDNA mutations. The proof of principle has now been extended to human embryos. Pronuclei were transferred between human zygotes, which developed onwards to the blastocyst stage in vitro. Carry-over of mtDNA from the donor zygotes to the recipients was minimal.
- Lyndsey Craven
- , Helen A. Tuppen
- & Douglass M. Turnbull
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News & Views |
Genomics of metastasis
Cancer cells that invade other parts of the body do so by accumulating genomic aberrations. Analysis of the genomic differences between primary and metastatic tumours should aid the understanding of this process.
- Joe Gray
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News & Views |
Lessons in complexity from yeast
A challenge in biology is to understand complex traits, which are influenced by many genetic variants. Studies in yeast provide the prospect of analysing such genetic variation in detail in other organisms, including humans.
- David B. Goldstein
- & Mohamed A. F. Noor
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Article |
Widespread transcription at neuronal activity-regulated enhancers
Regulatory proteins bind non-coding DNA either at promoters (near to a gene's transcription start site) or at enhancers (far away). Binding at enhancers helps to bring the transcription enzyme RNA polymerase to promoters. Here, studies of some 12,000 enhancers that respond to electrical activity in neurons show that binding to enhancers also brings the polymerase to the enhancers themselves, where it transcribes a novel class of non-coding RNAs. Enhancers may thus be more similar to promoters than hitherto appreciated.
- Tae-Kyung Kim
- , Martin Hemberg
- & Michael E. Greenberg
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News |
Anonymizing patient records for genomics
New method for concealing identity could open up more data for science.
- Daniel Cressey
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Research Highlights |
Cancer biology: Brain tumour trigger
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Research Highlights |
Developmental biology: Hidden differences
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Article |
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
Copy number variants (CNVs) account for a major proportion of human genetic diversity and may contribute to genetic susceptibility to disease. Here, a large, genome-wide study of association between common CNVs and eight common human diseases is presented. The study provides a wealth of technical insights that will inform future study design and analysis. The results also indicate that common CNVs that can be 'typed' on existing platforms are unlikely to contribute much to the genetic basis of common diseases.
- Nick Craddock
- , Matthew E. Hurles
- & Peter Donnelly
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Letter
| Open AccessGenome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis
Studies of identical twins are widely used to dissect the contributions of genes and the environment to human diseases. In multiple sclerosis, an autoimmune demyelinating disease, identical twins often show differences. This might suggest that environmental effects are most significant in this case, but genetic and epigenetic differences between identical twins have been described. Here, however, studies of identical twins show no evidence for genetic, epigenetic or transcriptome differences that could explain disease discordance.
- Sergio E. Baranzini
- , Joann Mudge
- & Stephen F. Kingsmore
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Letter |
A role for host–parasite interactions in the horizontal transfer of transposons across phyla
'Horizontal gene transfer' refers to the passage of genetic material between non-mating species. Transposable elements (transposons) may be especially prone to horizontal gene transfer, but the mechanisms by which they can spread across diverged species have been elusive. Here it is shown that transposons can spread by hitchhiking in the genomes of parasites. The amount of DNA that can be transferred in this way underscores the impact of horizontal gene transfer on genome evolution.
- Clément Gilbert
- , Sarah Schaack
- & Cédric Feschotte
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Review Article |
Genetics, pathogenesis and clinical interventions in type 1 diabetes
- Jeffrey A. Bluestone
- , Kevan Herold
- & George Eisenbarth
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Letter |
IκBζ regulates TH17 development by cooperating with ROR nuclear receptors
Interleukin-17-producing helper T (TH17) cells are a distinct T-cell subset characterized by its role in autoimmune disease. Here it is shown that the development of TH17 cells requires the transcription factor IκBζ, as well as nuclear receptors of the ROR family. Mice lacking IκBζ have a defect in TH17 development and are resistant to the induction of experimental autoimmune encephalomyelitis. The study points to some new potential molecular targets for drugs to treat autoimmune disease.
- Kazuo Okamoto
- , Yoshiko Iwai
- & Hiroshi Takayanagi
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Article |
Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes
High-throughput microscopy combined with gene silencing by RNA interference is a powerful method for studying gene function. Here, a genome-wide method is presented for phenotypic screening of each of the ∼21,000 human protein-coding genes, using two-day imaging of dividing cells with fluorescently labelled chromosomes. The method enabled the identification of hundreds of genes involved in biological functions such as cell division, migration and survival.
- Beate Neumann
- , Thomas Walter
- & Jan Ellenberg
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Article |
Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1
Adiponectin is a protein with anti-diabetic properties; its levels are decreased in obesity, insulin resistance and type 2 diabetes. It is shown here that mice with a muscle-specific disruption of adiponectin receptor 1 (AdipoR1) are insulin resistant and less able to endure exercise. The pathway downstream of receptor activation is delineated; the findings suggest that the decreased levels of adiponectin and AdipoR1 seen in obesity may have causal roles in the mitochondrial dysfunction and insulin resistance seen in diabetes.
- Masato Iwabu
- , Toshimasa Yamauchi
- & Takashi Kadowaki
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Letter |
NINJA connects the co-repressor TOPLESS to jasmonate signalling
In plants, the hormone jasmonoyl-isoleucine (JA-Ile) regulates growth, development and defence against pathogens. Proteins of the JAZ family repress JA-Ile-dependent gene expression, but the mechanism has been unclear. Here, an adaptor protein, NINJA, has been identified, which recruits co-repressor proteins that are known to mediate auxin-responsive gene expression as well. Hence these co-repressors are part of general repression complexes that are recruited to several different signalling pathways.
- Laurens Pauwels
- , Gemma Fernández Barbero
- & Alain Goossens
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Letter |
Evolution of self-compatibility in Arabidopsis by a mutation in the male specificity gene
Self-fertilisation (selfing) in plants is prevented mainly by the self-incompatibility recognition system, which consists of male and female specificity genes and modifier genes. Selfing does occur in Arabidopsis plants, but it is not known how it arose. Here it is reported that selfing in Arabidopsis results from a geographically widespread, 213-base-pair inversion within the male specificity gene. When this inversion is returned to its original orientation, selfing is prevented once more.
- Takashi Tsuchimatsu
- , Keita Suwabe
- & Kentaro K. Shimizu
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Letter
| Open AccessThe genome of a songbird
The genome of the zebra finch — a songbird and a model for studying the vertebrate brain, behaviour and evolution — has been sequenced. Comparison with the chicken genome, the only other bird genome available, shows that genes that have neural function and are implicated in the cognitive processing of song have been evolving rapidly in the finch lineage. Moreover, vocal communication engages much of the transcriptome of the zebra finch brain.
- Wesley C. Warren
- , David F. Clayton
- & Richard K. Wilson
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News Feature |
Human genome at ten: The sequence explosion
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Research Highlights |
Genomics: DNA packaging unravelled
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Editorial |
The human genome at ten
Nearly a decade on from the completion of the draft sequence of the human genome, researchers should work with the same intensity and focus to apply the results to health.
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Opinion |
Multiple personal genomes await
Genomic data will soon become a commodity; the next challenge — linking human genetic variation with physiology and disease — will be as great as the one genomicists faced a decade ago, says J. Craig Venter.
- J. Craig Venter
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Opinion |
Counterpoint: Data first
Large, unbiased genomic surveys are taking cancer therapeutics in directions that could never have been predicted by traditional molecular biology, says Todd Golub. This Opinion piece is part of a linked pair; see also Point: Hypothesis First by Robert Weinberg.
- Todd Golub
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Opinion |
Has the revolution arrived?
Looking back over the past decade of human genomics, Francis Collins finds five key lessons for the future of personalized medicine — for technology, policy, partnerships and pharmacogenomics.
- Francis Collins
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News Feature |
Human genome at ten: Life is complicated
The more biologists look, the more complexity there seems to be. Erika Check Hayden asks if there's a way to make life simpler.
- Erika Check Hayden
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News & Views |
Genome-wide view of mitosis
An exceptionally large-scale project aimed at assigning function to all protein-coding genes in the human genome is reported on page 721 by Neumann et al.
1 . Here are two complementary views on the experimental design and analysis, and on how useful the findings will be to cell biologists.- Jason R. Swedlow
- , Cecilia Cotta-Ramusino
- & Stephen J. Elledge
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News |
Gene flaw found in induced stem cells
Key difference between reprogrammed adult mouse cells and embryonic stem cells discovered.
- Elie Dolgin
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Column |
Bursting the genomics bubble
The Human Genome Project attracted investment beyond what a rational analysis would have predicted. There are pros and cons to that, says Philip Ball.
- Philip Ball
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Letter
| Open AccessPérigord black truffle genome uncovers evolutionary origins and mechanisms of symbiosis
The genome of the black truffle - one of the most popular truffles on the market - has been sequenced. This is the first genome of a symbiotic ascomycete to be analysed. Comparison with the genome of another ectomycorrhizal symbiotic fungus indicates that a genetic predisposition to symbiosis evolved differently in ascomycetes and basidiomycetes. The study also offers insight into fungal sex and fruiting.
- Francis Martin
- , Annegret Kohler
- & Patrick Wincker
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Correspondence |
Questions over the scientific basis of epigenome project
- Mark Ptashne
- , Oliver Hobert
- & Eric Davidson
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Research Highlights |
Genetics: Cross out crossovers
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News |
Fossil finger points to new human species
DNA analysis reveals lost relative from 40,000 years ago.
- Rex Dalton
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Letter
| Open AccessThe complete mitochondrial DNA genome of an unknown hominin from southern Siberia
Ancient mitochondrial DNA from a hominin individual who lived in the mountains of Central Asia between 48,000–30,000 years ago has been sequenced. Comparative genomics suggest that this mitochondrial DNA derives from an out-of-Africa migration distinct from the ones that gave rise to Neanderthals and modern humans. It also seems that this hominin lived in close spatio-temporal proximity to Neanderthals and modern humans.
- Johannes Krause
- , Qiaomei Fu
- & Svante Pääbo
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Article |
Zscan4 regulates telomere elongation and genomic stability in ES cells
Zscan4 is shown to be involved in maintaining telomeres in embryonic stem (ES) cells. Only 5% of ES cells express Zscan4 at a given time, but nearly all ES cells activate Zscan4 at least once within nine passages. The transient Zscan4-positive state is associated with rapid telomere extension by telomere recombination and upregulation of meiosis–specific homologous recombination genes. Knocking down Zscan4 shortens telomeres, increases karyotype abnormalities and spontaneous sister chromatid exchange, and slows down cell proliferation until reaching crisis by eight passages.
- Michal Zalzman
- , Geppino Falco
- & Minoru S. H. Ko
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Letter |
Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines
Here, large-scale genome-wide association studies were carried out with the naturally occurring inbred lines of Arabidopsis thaliana, which can be genotyped once and phenotyped repeatedly. The results range from significant associations, usually corresponding to single genes, to findings that are more difficult to interpret, because confounding by complex genetics and population structure makes it hard to distinguish true associations from false.
- Susanna Atwell
- , Yu S. Huang
- & Magnus Nordborg
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News |
Bizarre models for human diseases
Plants shed light on disfigured faces, and yeast and blood vessels find common ground.
- Janelle Weaver
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News |
Cancer genes silenced in humans
Tiny particles carrying short strands of RNA can interfere with protein production in tumours.
- Janet Fang
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Letter |
Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells
In multicellular organisms, apoptotic cells are removed from tissues by phagocytes, which recognize and engulf the dying cells. The molecular mechanisms underlying the subsequent degradation of the cells have been unclear. Here, two evolutionarily conserved genes have been identified that are required for such processing in Caenorhabditis elegans and mammals. An understanding of these events could lead to new treatments for diseases associated with poor engulfment and destruction of dying cells.
- Jason M. Kinchen
- & Kodi S. Ravichandran
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Article
| Open AccessComparative genomics reveals mobile pathogenicity chromosomes in Fusarium
Fungi from the genus Fusarium are important pathogens of animals and crop plants. Some have a wide host range, whereas others are more specific in the organisms they infect. Here, clues are provided as to how differences in specificity come about. The genomes of two Fusarium fungi with differing host ranges have been sequenced, and compared with the genome of a third species. Experiments show that transferring two whole chromosomes turns a non-pathogenic Fusarium strain into a pathogenic one.
- Li-Jun Ma
- , H. Charlotte van der Does
- & Martijn Rep
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Research Highlights |
Genomics: We are family
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Research Highlights |
Virology: Infectious inheritance
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News & Views |
Pregnant fathers in charge
Pipefish and related species provide rare examples of extreme male parental care. Controlled breeding experiments allow the resulting conflicts of interest between female, male and offspring to be explored.
- Anders Berglund
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