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A haplotype-resolved pan-genome of autotetraploid European potato founder lines shows high nucleotide diversity at remarkably low haplotype diversity, which is probably the result of hybridization events with wild potato species, followed by population bottlenecks during domestication and transition to Europe.
Dnmt3a mutations in mouse haematopoietic stem and progenitor cells equivalent to R882 mutations in human cause increased mitochondrial respiration, suggesting that this is a mechanism of clonal haematopoiesis and a potential therapeutic target.
Experimental and theoretical exploration of domain walls forming in wurtzite ferroelectrics following the application of electric fields demonstrates their reconfigurable conductivity as well as tunability, showing potential for use in ultrascaled devices.
Liver organoids derived from human induced pluripotent stem cells populations grown with ascorbate and bilirubin can be used to recapitulate differential zonal functions of human hepatocytes and for transplantation in animal models of liver dysfunction.
A pangenome of wild and cultivated rice accessions captures the entire set of non-redundant genes and diversity in rice, and provides insights into the pathways involved in the evolution of rice.
The structure and function of the MCR activation complex from Methanococcus maripaludis were revealed, demonstrating its ATP-dependent ability to activate MCR and form methane while uncovering a unique electron transfer pathway involving iron–sulfur clusters similar to the nitrogenase cofactor intermediates.
A method, RARE-seq, for sensitive detection of cell-free RNAs in blood is demonstrated to have diverse clinical applications including diagnosing and characterizing human cancers, and tracking response to RNA therapeutics.
The dynamical axion quasiparticle, which is directly analogous to the hypothetical fundamental axion particle, is observed in two-dimensional MnBi2Te4, and has implications for quantum chromodynamics, cosmology and string theory.
A two-dimensional Dirac graphene-channel flash memory based on a two-dimensional-enhanced hot-carrier-injection mechanism that supports both electron and hole injection is used to make devices with a subnanosecond program speed.
Seismic reflection imaging beneath the northeastern Yellowstone caldera reveals a sharp boundary at about 3.8 km depth, which is inferred to result from a mixture of supercritical fluid and magma filling the pore space.
New fully integrated semiconductor laser architectures are shown to be able to generate bright and background-free picosecond solitons at GHz repetition rates in the mid-infrared range.
