Correspondence |
Featured
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News Feature |
AI image generators often give racist and sexist results: can they be fixed?
Researchers are tracing sources of racial and gender bias in images generated by artificial intelligence, and making efforts to fix them.
- Ananya
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Article |
Structural insights into vesicular monoamine storage and drug interactions
- Jin Ye
- , Huaping Chen
- & Weikai Li
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Where I Work |
I study small organisms to tackle big climate problems
Marine biologist Gabriel Renato Castro cultivates compounds from cyanobacteria to support agriculture and the environment.
- Nikki Forrester
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News & Views |
Can lessons from infants solve the problems of data-greedy AI?
Words and images experienced by an infant wearing sensors during their daily life have led to efficient machine learning, pointing to the power of multimodal training signals and to the potentially exploitable statistics of real-life experience.
- Linda B. Smith
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Research Briefing |
‘Bandit’ algorithms help chemists to discover generally applicable conditions for reactions
In organic chemistry, finding conditions that enable a broad range of compounds to undergo a particular type of reaction is highly desirable. However, conventional methods for doing so consume a lot of time and reagents. A machine-learning method has been developed that overcomes these problems.
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News |
Bird-flu threat disrupts Antarctic penguin studies
Projects have been cancelled in an effort to curb the virus’s spread.
- Carissa Wong
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News |
First US drug approved for a liver disease surging around the world
A therapy called resmetirom improves hallmarks of an obesity-linked condition that can lead to liver failure.
- Heidi Ledford
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Career Feature |
The neuroscientist formerly known as Prince’s audio engineer
Susan Rogers worked with the legendary singer-songwriter before earning a PhD in her 50s on auditory memory and how we listen to music throughout life.
- Anne Gulland
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Outlook |
Fungal diseases are spreading undetected
Low- and middle-income countries are grappling with widespread shortages of diagnostic tests for infections that kill millions.
- Charles Schmidt
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News |
Ditching ‘Anthropocene’: why ecologists say the term still matters
Beyond stratigraphic definitions, the name has broader significance for understanding humans’ place on Earth.
- David Adam
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Nature Video |
Building a heart atlas: researchers map organ in stunning detail
Cutting edge imaging techniques reveal how cells organise as the heart develops.
- Dan Fox
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Nature Index |
Four change-makers seek impact in medical research
Bringing fresh perspectives to long-standing health challenges, these scientists are using techniques such as big-data analytics and AI to push the field.
- Amy Coombs
- & Sandy Ong
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Obituary |
Anthony Epstein (1921–2024), discoverer of virus causing cancer in humans
Pathologist whose finding that viruses can trigger tumours in humans transformed medical research.
- Alan Rickinson
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News & Views |
Mobile delivery of COVID-19 vaccines improved uptake in rural Sierra Leone
A trial that took mobile health services to rural Sierra Leone finds that this initiative increased COVID-19 vaccine uptake. But more must be done to expand the coverage of health services in low-income countries.
- Alison Buttenheim
- & Harsha Thirumurthy
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News & Views |
Whales make waves in the quest to discover why menopause evolved
Why do several species of whale experience menopause, and why does the phenomenon occur at all? Analysing whale data might help to answer these questions and shed light on why menopause evolved in humans.
- Rebecca Sear
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Nature Index |
How AI is being used to accelerate clinical trials
From study design to patient recruitment, researchers are investigating ways that technology could speed up the process.
- Matthew Hutson
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Nature Index |
Researchers call for a major rethink of how Alzheimer’s treatments are evaluated
An approach that aims to quantify how long a drug can delay or halt the progression of disease is gathering steam.
- Esther Landhuis
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Nature Index |
A spotlight on the stark imbalances of global health research
An expansion of the Nature Index to include more than 60 medical journals has revealed the clear leaders in the field.
- Bec Crew
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News |
Deadly brain cancer shrinks after CAR-T therapy — but for how long is unclear
Early studies with engineered immune cells show drastic but often short-lived results in glioblastoma, the most aggressive brain cancer.
- Heidi Ledford
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Nature Podcast |
Killer whales have menopause. Now scientists think they know why
Data suggest menopause evolved to enable older female whales to help younger generations survive, and how researchers made a cellular map of the developing human heart.
- Benjamin Thompson
- & Nick Petrić Howe
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News |
Massive public-health experiment sends vaccination rates soaring
The rate of vaccination against COVID-19 rose sharply in villages in Sierra Leone where health officials held mobile vaccination clinics.
- Max Kozlov
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Article
| Open AccessSpatially organized cellular communities form the developing human heart
Combining single-cell RNA-sequencing with high-resolution multiplexed error-robust fluorescence in situ hybridization reveals in detail the cellular interactions and specialization of cardiac cell types that form and remodel the human heart.
- Elie N. Farah
- , Robert K. Hu
- & Neil C. Chi
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Article
| Open AccessSubstrate-induced condensation activates plant TIR domain proteins
Binding of the substrates NAD+ and ATP to the plant Toll/interleukin-1 receptor (TIR) domain proteins induces phase separation and, thereby, activation of TIR enzymatic and immune signalling activity.
- Wen Song
- , Li Liu
- & Jijie Chai
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Article |
Time-resolved cryo-EM of G-protein activation by a GPCR
Time-resolved cryo-EM is used to capture structural transitions during G-protein activation stimulated by a G-protein-coupled receptor.
- Makaía M. Papasergi-Scott
- , Guillermo Pérez-Hernández
- & Georgios Skiniotis
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Article
| Open AccessEvolutionary trajectories of small cell lung cancer under therapy
We uncover key processes of the genomic evolution of small cell lung cancer under therapy, identify the common ancestor as the source of clonal diversity at relapse and show central genomic patterns associated with drug response.
- Julie George
- , Lukas Maas
- & Roman K. Thomas
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Article
| Open AccessAnoxygenic phototroph of the Chloroflexota uses a type I reaction centre
Cultivation of a new anoxygenic phototrophic bacterium from Boreal Shield lake water—representing a transition form in the evolution of photosynthesis—offers insights into how the major modes of phototrophy diversified.
- J. M. Tsuji
- , N. A. Shaw
- & J. D. Neufeld
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News & Views |
Epstein–Barr virus at 60
The 1964 discovery of Epstein–Barr virus shed light on factors that contribute to human cancer. Subsequent studies set the stage for finding ways to diagnose and treat cancer, and revealed how immune defences control viral infection.
- Lawrence S. Young
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Article
| Open AccessBlueprinting extendable nanomaterials with standardized protein blocks
A study describes an approach using designed building blocks that are far more regular in geometry than natural proteins to construct modular multicomponent protein assemblies.
- Timothy F. Huddy
- , Yang Hsia
- & David Baker
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Article
| Open AccessAPOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia
A microglial state, featuring lipid droplets and secretion of neurotoxic factors, is shown to be most prominent in people with Alzheimer’s disease who have the APOE4 genotype.
- Michael S. Haney
- , Róbert Pálovics
- & Tony Wyss-Coray
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News |
Chatbot AI makes racist judgements on the basis of dialect
Some large language models harbour hidden biases that cannot be removed using standard methods.
- Elizabeth Gibney
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News Feature |
Why are so many young people getting cancer? What the data say
Clues to a modern mystery could be lurking in information collected generations ago.
- Heidi Ledford
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News |
Ancient malaria genome from Roman skeleton hints at disease’s history
Genetic information from ancient remains is helping to reveal how malaria has moved and evolved alongside people.
- Tosin Thompson
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Article |
AIRE relies on Z-DNA to flag gene targets for thymic T cell tolerization
Z-DNA anchors the AIRE-mediated transcriptional program by enhancing the generation of double-stranded breaks and promoter poising.
- Yuan Fang
- , Kushagra Bansal
- & Diane Mathis
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Article |
Dopamine receptor D2 confers colonization resistance via microbial metabolites
In a mouse model of enteric pathogen infection, tryptophan metabolites protect against infection via activation of dopamine receptor D2 and regulation of actin cytoskeletal organization in intestinal epithelial cells.
- Samantha A. Scott
- , Jingjing Fu
- & Pamela V. Chang
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Article
| Open AccessMitochondrial complex I activity in microglia sustains neuroinflammation
Blocking mitochondrial complex I in pro-inflammatory microglia protects the central nervous system against neurotoxic damage and improves functional outcomes in vivo in an animal disease model.
- L. Peruzzotti-Jametti
- , C. M. Willis
- & S. Pluchino
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Article |
Rapid unleashing of macrophage efferocytic capacity via transcriptional pause release
Macrophages are revealed to adopt a polymerase II pause/release process to effectively deal with ingested apoptotic corpses and for continuous efferocytosis.
- Turan Tufan
- , Gamze Comertpay
- & Kodi S. Ravichandran
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Article
| Open AccessThe evolution of menopause in toothed whales
A comparative analysis tests competing evolutionary hypotheses in toothed whales in which menopause has evolved many times as females extended their overall lifespan but not their reproductive lifespan, increasing their opportunity for intergenerational help without increasing intergenerational reproductive competition.
- Samuel Ellis
- , Daniel W. Franks
- & Darren P. Croft
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Article |
Neural signatures of natural behaviour in socializing macaques
Single-neuron and population activity in the macaque prefrontal and temporal cortex robustly encodes 24 species-typical behaviours, reciprocity in social interactions and social support.
- Camille Testard
- , Sébastien Tremblay
- & Michael L. Platt
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Article |
Self-enhanced mobility enables vortex pattern formation in living matter
We demonstrate that self-enhanced mobility offers a simple physical mechanism for pattern formation in living systems and, more generally, in other active matter systems near the boundary of fluid- and solid-like behaviours.
- Haoran Xu
- & Yilin Wu
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Correspondence |
On the ethics of informed consent in genetic data collected before 1997
- Martin Zieger
- , Yann Joly
- & Maria Eugenia D’Amato
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Article |
Structures and activation mechanism of the Gabija anti-phage system
- Jing Li
- , Rui Cheng
- & Longfei Wang
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Correspondence |
Embrace AI to break down barriers in publishing for people who aren’t fluent in English
- Charles Morphy D. Santos
- & João Paulo Gois
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News & Views |
From the archive: Brain–body connection, and cuttlefish ink distracts predators
Snippets from Nature’s past.
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Where I Work |
Why I wander with wonder through Lesotho’s wetlands
Lerato Seleteng-Kose studies the unique plants that live in these cold, remote parts of southern Africa.
- Linda Nordling
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Research Briefing |
Dysregulated cellular stress management becomes a source of stress
Stress responses protect cells from harmful conditions, but once the stress has resolved, these responses must be actively turned off to avoid cell damage that might lead to the development of neurodegenerative disease.
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Technology Feature |
No installation required: how WebAssembly is changing scientific computing
Enabling code execution in the web browser, the multilanguage tool is powerful but complicated.
- Jeffrey M. Perkel
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News |
Blockbuster obesity drug leads to better health in people with HIV
Semaglutide reduces weight and fat accumulation associated with the antiretroviral regimen that keeps HIV at bay.
- Mariana Lenharo
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News Explainer |
First cell therapy for solid tumours heads to the clinic: what it means for cancer treatment
Therapy built on tumour-infiltrating lymphocytes is now being prepared for at least 20 people in the United States with advanced melanoma.
- Sara Reardon
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News |
Indigenous Australian fire-stick farming began at least 11,000 years ago
Analysis of a sediment core dating back 150,000 years showed that fire patterns in Australia changed with the rise of Indigenous people’s use of fire.
- Bianca Nogrady
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