Quantitative trait articles within Nature

Featured

  • Article
    | Open Access

    Comparisons of phenotypic and genetic association with protein levels from Icelandic and UK Biobank cohorts show that using multiple analysis platforms and stratifying populations by ancestry improves the detection of associations and allows the refinement of their location within the genome.

    • Grimur Hjorleifsson Eldjarn
    • , Egil Ferkingstad
    •  & Kari Stefansson

  • Article |

    A machine learning approach is used to analyse multi-omics (proteomics, metabolomics and transcriptomics) data, producing genetic scores for more than 17,000 biomolecular traits in human blood, and identifying possible associations with disease.

    • Yu Xu
    • , Scott C. Ritchie
    •  & Michael Inouye

  • Article
    | Open Access

    A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

    • Loïc Yengo
    • , Sailaja Vedantam
    •  & Joel N. Hirschhorn

  • Article
    | Open Access

    Genome-wide association studies of brain imaging data from 8,428 individuals in UK Biobank show that many of the 3,144 traits studied are heritable, and genes associated with individual phenotypes are identified.

    • Lloyd T. Elliott
    • , Kevin Sharp
    •  & Stephen M. Smith

  • Article |

    A genetic atlas of the human plasma proteome, comprising 1,927 genetic associations with 1,478 proteins, identifies causes of disease and potential drug targets.

    • Benjamin B. Sun
    • , Joseph C. Maranville
    •  & Adam S. Butterworth

  • Letter |

    A detailed analysis of fly wing phenotypes reveals a strong positive relationship between variation produced by mutation, standing genetic variation, and evolutionary rate over the past 40 million years.

    • David Houle
    • , Geir H. Bolstad
    •  & Thomas F. Hansen

  • Article |

    Parental care in mice evolves through multiple genetic changes; one candidate is vasopressin, the reduced expression of which promotes parental nest-building behaviour in monogamous mice.

    • Andres Bendesky
    • , Young-Mi Kwon
    •  & Hopi E. Hoekstra

  • Letter |

    Multi-ancestry genome-wide association analyses for birth weight in 153,781 individuals identified 60 genomic loci in which birth weight and fetal genotype were associated and found an inverse genetic correlation between birth weight and cardiometabolic risk.

    • Momoko Horikoshi
    • , Robin N. Beaumont
    •  & Rachel M. Freathy

  • Article |

    The effect of natural genetic diversity on the proteome is characterized using an outbred mouse model with extensive variation; both transcripts and proteins from mouse livers are quantified to identify a large set of protein quantitative trait loci (pQTL), and mediation analysis identifies causal protein intermediates of distant pQTL.

    • Joel M. Chick
    • , Steven C. Munger
    •  & Steven P. Gygi

  • Letter |

    A diverse range of molecular and genetic manipulations all alter lifespan distributions of Caenorhabditis elegans by an apparent stretching or shrinking of time.

    • Nicholas Stroustrup
    • , Winston E. Anthony
    •  & Walter Fontana

  • Letter |

    Quantifying activity of cis-regulatory sequences controlling gene expression shows that selection on expression noise has a greater impact on sequence variation than selection on mean expression level.

    • Brian P. H. Metzger
    • , David C. Yuan
    •  & Patricia J. Wittkopp

  • Letter |

    A large-scale analysis of variation in human protein levels between individuals is performed using mass-spectrometry-based proteomic technology, and a number of protein quantitative trait loci are identified; over 5% of proteins vary by more than 1.5-fold in their expression levels between individuals, and this variation is not always linked to RNA level.

    • Linfeng Wu
    • , Sophie I. Candille
    •  & Michael Snyder

  • Article |

    By combining full-genome sequencing and ‘evolutionary replay’ experiments to dissect the origin of aerobic citrate use in an experimental Escherichia coli population over 40,000 generations and 2 decades, the authors unveil a 3-step process in which potentiation makes a trait possible, actualization makes the trait manifest and refinement makes it effective.

    • Zachary D. Blount
    • , Jeffrey E. Barrick
    •  & Richard E. Lenski

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