Featured
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Article |
Breakage of cytoplasmic chromosomes by pathological DNA base excision repair
DNA damage during chromothripsis is caused by deoxyinosine formation on accumulated RNA–DNA hybrids in micronuclei that are then recognized by N-methyl-purine DNA glycosylase and cleaved by apurinic/apyrimidinic endonuclease.
- Shangming Tang
- , Ema Stokasimov
- & David Pellman
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Letter |
Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells
Generation of human induced pluripotent stem cells from patient fibroblasts containing ring chromosomes with large deletions reveals that reprogrammed cells lose the abnormal chromosome and duplicate the wild-type homologue through compensatory uniparental disomy, suggesting that cellular reprogramming may hold potential for ‘chromosome therapy’.
- Marina Bershteyn
- , Yohei Hayashi
- & Anthony Wynshaw-Boris
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Research Highlights |
A way to catch dividing cells
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Letter |
PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos
The binding of PGC7 to maternal chromatin, which is important for methylation maintenance during embryogenesis, is shown to be dependent on a particular histone modification, H3K9me2.
- Toshinobu Nakamura
- , Yu-Jung Liu
- & Toru Nakano
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Letter |
The ploidy conveyor of mature hepatocytes as a source of genetic variation
Cells that make up the liver are known to be polyploid. These authors show that mouse hepatocytes can increase and decrease their ploidy in vivo; increases occur as a result of failed cytokinesis, and decreases occur as a result of multipolar mitosis. The resulting genetic heterogeneity might be advantageous following hepatic injury, allowing the selection of 'genetically robust' cells from a pre-existing pool of diverse genotypes.
- Andrew W. Duncan
- , Matthew H. Taylor
- & Markus Grompe
Cancer aneuploidies are shaped primarily by effects on tumour fitness
Derivation of haploid embryonic stem cells from mouse embryos