Collection |

Cancer at Nature Research

The Nature Research editors who handle cancer primary research, methods, protocols and reviews bring you the latest articles, covering all aspects from disease mechanisms to therapeutic approaches. Collected here you will also find specially curated content, such as collections, focus issues and animations, all ready to be used in presentations and educational materials. You can also find out about the editors handling cancer contents, and the journals at Nature Research that publish articles on this topic and how to submit to them.

Sign up to the e-alert to receive highlights direct to your inbox.

Research Articles

  • Nature Biotechnology | Article

    Anti-PD-1 secreted by CAR-T cells remains localized to the tumor and improves therapeutic outcome in mice.

    • Sarwish Rafiq
    • , Oladapo O Yeku
    • , Hollie J Jackson
    • , Terence J Purdon
    • , Dayenne G van Leeuwen
    • , Dylan J Drakes
    • , Mei Song
    • , Matthew M Miele
    • , Zhuoning Li
    • , Pei Wang
    • , Su Yan
    • , Jingyi Xiang
    • , Xiaojing Ma
    • , Venkatraman E Seshan
    • , Ronald C Hendrickson
    • , Cheng Liu
    •  &  Renier J Brentjens
  • Nature Communications | Article | open

    The chromosome 15q25.1 locus is a leading susceptibility region for lung cancer. Here, the authors interrogate three GWAS cohorts with 42,901 individuals to investigate potential pathological pathways such as gated channel activity and neuroactive ligand receptor interaction in lung cancer etiology.

    • Xuemei Ji
    • , Yohan Bossé
    • , Maria Teresa Landi
    • , Jiang Gui
    • , Xiangjun Xiao
    • , David Qian
    • , Philippe Joubert
    • , Maxime Lamontagne
    • , Yafang Li
    • , Ivan Gorlov
    • , Mariella de Biasi
    • , Younghun Han
    • , Olga Gorlova
    • , Rayjean J. Hung
    • , Xifeng Wu
    • , James McKay
    • , Xuchen Zong
    • , Robert Carreras-Torres
    • , David C. Christiani
    • , Neil Caporaso
    • , Mattias Johansson
    • , Geoffrey Liu
    • , Stig E. Bojesen
    • , Loic Le Marchand
    • , Demetrios Albanes
    • , Heike Bickeböller
    • , Melinda C. Aldrich
    • , William S. Bush
    • , Adonina Tardon
    • , Gad Rennert
    • , Chu Chen
    • , M. Dawn Teare
    • , John K. Field
    • , Lambertus A. Kiemeney
    • , Philip Lazarus
    • , Aage Haugen
    • , Stephen Lam
    • , Matthew B. Schabath
    • , Angeline S. Andrew
    • , Hongbing Shen
    • , Yun-Chul Hong
    • , Jian-Min Yuan
    • , Pier A. Bertazzi
    • , Angela C. Pesatori
    • , Yuanqing Ye
    • , Nancy Diao
    • , Li Su
    • , Ruyang Zhang
    • , Yonathan Brhane
    • , Natasha Leighl
    • , Jakob S. Johansen
    • , Anders Mellemgaard
    • , Walid Saliba
    • , Christopher Haiman
    • , Lynne Wilkens
    • , Ana Fernandez-Somoano
    • , Guillermo Fernandez-Tardon
    • , Erik H. F. M. van der Heijden
    • , Jin Hee Kim
    • , Juncheng Dai
    • , Zhibin Hu
    • , Michael P. A. Davies
    • , Michael W. Marcus
    • , Hans Brunnström
    • , Jonas Manjer
    • , Olle Melander
    • , David C. Muller
    • , Kim Overvad
    • , Antonia Trichopoulou
    • , Rosario Tumino
    • , Jennifer Doherty
    • , Gary E. Goodman
    • , Angela Cox
    • , Fiona Taylor
    • , Penella Woll
    • , Irene Brüske
    • , Judith Manz
    • , Thomas Muley
    • , Angela Risch
    • , Albert Rosenberger
    • , Kjell Grankvist
    • , Mikael Johansson
    • , Frances Shepherd
    • , Ming-Sound Tsao
    • , Susanne M. Arnold
    • , Eric B. Haura
    • , Ciprian Bolca
    • , Ivana Holcatova
    • , Vladimir Janout
    • , Milica Kontic
    • , Jolanta Lissowska
    • , Anush Mukeria
    • , Simona Ognjanovic
    • , Tadeusz M. Orlowski
    • , Ghislaine Scelo
    • , Beata Swiatkowska
    • , David Zaridze
    • , Per Bakke
    • , Vidar Skaug
    • , Shanbeh Zienolddiny
    • , Eric J. Duell
    • , Lesley M. Butler
    • , Woon-Puay Koh
    • , Yu-Tang Gao
    • , Richard Houlston
    • , John McLaughlin
    • , Victoria Stevens
    • , David C. Nickle
    • , Ma’en Obeidat
    • , Wim Timens
    • , Bin Zhu
    • , Lei Song
    • , María Soler Artigas
    • , Martin D. Tobin
    • , Louise V. Wain
    • , Fangyi Gu
    • , Jinyoung Byun
    • , Ahsan Kamal
    • , Dakai Zhu
    • , Rachel F. Tyndale
    • , Wei-Qi Wei
    • , Stephen Chanock
    • , Paul Brennan
    •  &  Christopher I. Amos
  • Nature Genetics | Article

    The authors identify copy number signatures from shallow whole-genome sequencing of high-grade serous ovarian cancer (HGSOC) cases. HGSOC comprises a continuum of genomes shaped by multiple mutational processes that result in genomic aberration.

    • Geoff Macintyre
    • , Teodora E. Goranova
    • , Dilrini De Silva
    • , Darren Ennis
    • , Anna M. Piskorz
    • , Matthew Eldridge
    • , Daoud Sie
    • , Liz-Anne Lewsley
    • , Aishah Hanif
    • , Cheryl Wilson
    • , Suzanne Dowson
    • , Rosalind M. Glasspool
    • , Michelle Lockley
    • , Elly Brockbank
    • , Ana Montes
    • , Axel Walther
    • , Sudha Sundar
    • , Richard Edmondson
    • , Geoff D. Hall
    • , Andrew Clamp
    • , Charlie Gourley
    • , Marcia Hall
    • , Christina Fotopoulou
    • , Hani Gabra
    • , James Paul
    • , Anna Supernat
    • , David Millan
    • , Aoisha Hoyle
    • , Gareth Bryson
    • , Craig Nourse
    • , Laura Mincarelli
    • , Luis Navarro Sanchez
    • , Bauke Ylstra
    • , Mercedes Jimenez-Linan
    • , Luiza Moore
    • , Oliver Hofmann
    • , Florian Markowetz
    • , Iain A. McNeish
    •  &  James D. Brenton
  • Nature Communications | Article | open

    Determining the extent of immune cell infiltration into solid tumours is essential for adequate therapeutic response. Here the authors develop a DNA methylation-based approach for tumour cell fraction deconvolution and analyse tumour composition and genomics across a wide spectrum of solid cancers.

    • Ankur Chakravarthy
    • , Andrew Furness
    • , Kroopa Joshi
    • , Ehsan Ghorani
    • , Kirsty Ford
    • , Matthew J. Ward
    • , Emma V. King
    • , Matt Lechner
    • , Teresa Marafioti
    • , Sergio A. Quezada
    • , Gareth J. Thomas
    • , Andrew Feber
    •  &  Tim R. Fenton
  • Nature Immunology | Article

    Human follicular lymphomas arise from germinal center B cells. Milpied and colleagues use single-cell transcriptomic analysis to show that follicular lymphoma cells lose synchronized gene-expression patterns that characterize normal germinal center B cells.

    • Pierre Milpied
    • , Iñaki Cervera-Marzal
    • , Marie-Laure Mollichella
    • , Bruno Tesson
    • , Gabriel Brisou
    • , Alexandra Traverse-Glehen
    • , Gilles Salles
    • , Lionel Spinelli
    •  &  Bertrand Nadel
  • Nature Cell Biology | Article

    Nichols et al. identify an SHP2 inhibitor that disrupts SOS1-mediated RAS–GTP loading with demonstrated efficacy in various types of tumour driven by mutant BRAF, NF1 or RAS.

    • Robert J. Nichols
    • , Franziska Haderk
    • , Carlos Stahlhut
    • , Christopher J. Schulze
    • , Golzar Hemmati
    • , David Wildes
    • , Christos Tzitzilonis
    • , Kasia Mordec
    • , Abby Marquez
    • , Jason Romero
    • , Tientien Hsieh
    • , Aubhishek Zaman
    • , Victor Olivas
    • , Caroline McCoach
    • , Collin M. Blakely
    • , Zhengping Wang
    • , Gert Kiss
    • , Elena S. Koltun
    • , Adrian L. Gill
    • , Mallika Singh
    • , Mark A. Goldsmith
    • , Jacqueline A. M. Smith
    •  &  Trever G. Bivona

Reviews

  • Nature Reviews Clinical Oncology | Review Article

    The clinical management of patients with non-small-cell lung carcinoma has greatly evolved owing to the development of tyrosine-kinase inhibitors (TKIs) targeted against the driver mutations of this disease. The authors of this Review describe the existing evidence on the sequential administration of TKIs and the use of next-generation TKIs upfront.

    • Gonzalo Recondo
    • , Francesco Facchinetti
    • , Ken A. Olaussen
    • , Benjamin Besse
    •  &  Luc Friboulet
  • Nature Reviews Urology | Review Article

    Radical cystectomy plus concurrent pelvic lymph node dissection (PLND) provides oncological benefit and useful prognostic information. However, a lack of consensus exists regarding the optimal PLND template. Here, the authors describe and discuss the use of different PLND templates.

    • Marlon Perera
    • , Shannon McGrath
    • , Shomik Sengupta
    • , Jack Crozier
    • , Damien Bolton
    •  &  Nathan Lawrentschuk
  • Nature Reviews Cancer | Review Article

    This Review discusses nutrient scavenging, a process by which cancer cells use macromolecules from their environment to fuel cell metabolism and growth even when nutrients are limiting.

    • Brendan T. Finicle
    • , Vaishali Jayashankar
    •  &  Aimee L. Edinger
  • Nature Reviews Clinical Oncology | Consensus Statement | open

    Chimeric antigen receptor (CAR) T cell therapies have impressive activity in the treatment of cancer but are associated with potentially fatal toxicities. In light of the approval of CAR T cell therapy for paediatric patients, a panel of experts from the Hematopoietic Stem Cell Transplantation (HSCT) Subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, the CAR T Cell Therapy-Associated Toxicity (CARTOX) Program at The University of Texas MD Anderson Cancer Center, and several other institutions have developed consensus guidelines for the use and management of these treatments in paediatric patients, which are presented herein.

    • Kris M. Mahadeo
    • , Sajad J. Khazal
    • , Hisham Abdel-Azim
    • , Julie C. Fitzgerald
    • , Agne Taraseviciute
    • , Catherine M. Bollard
    • , Priti Tewari
    • , Christine Duncan
    • , Chani Traube
    • , David McCall
    • , Marie E. Steiner
    • , Ira M. Cheifetz
    • , Leslie E. Lehmann
    • , Rodrigo Mejia
    • , John M. Slopis
    • , Rajinder Bajwa
    • , Partow Kebriaei
    • , Paul L. Martin
    • , Jerelyn Moffet
    • , Jennifer McArthur
    • , Demetrios Petropoulos
    • , Joan O’Hanlon Curry
    • , Sarah Featherston
    • , Jessica Foglesong
    • , Basirat Shoberu
    • , Alison Gulbis
    • , Maria E. Mireles
    • , Lisa Hafemeister
    • , Cathy Nguyen
    • , Neena Kapoor
    • , Katayoun Rezvani
    • , Sattva S. Neelapu
    •  &  Elizabeth J. Shpall
  • Nature Reviews Endocrinology | Review Article

    Treatment protocols for thyroid cancers range from active surveillance to total thyroidectomy followed by radioiodine remnant ablation. In this Review, the authors discuss the strengths and weaknesses of the surveillance tools and follow-up strategies used by clinicians in the treatment of thyroid cancers.

    • Livia Lamartina
    • , Giorgio Grani
    • , Cosimo Durante
    • , Isabelle Borget
    • , Sebastiano Filetti
    •  &  Martin Schlumberger

News & Commentary

  • Nature Immunology | News & Views

    Single-cell transcriptomic analysis shows that B cells experience a continuum of cyclic transitional states during the germinal center (GC) reaction; this pattern is lost in GC-derived follicular lymphoma cells, which seem to be heterogeneous and desynchronized.

    • Katia Basso
  • Nature Reviews Urology | News & Views

    New data have confirmed the genomic diversity of low-risk prostate cancer. Improved understanding of the heterogeneity of this disease has implications for disease management and has the potential to change treatment for patients in the future.

    • Vidit Sharma
    •  &  R. Jeffrey Karnes
  • Nature Biomedical Engineering | News & Views

    Intratumoral injection of a hydrogel impregnated with radioisotope-labelled catalase and an immunostimulant, along with systemic immune checkpoint blockade, inhibits tumour growth in mouse models of localized cancer and metastatic cancer.

    • Catherine S. Spina
    •  &  Charles G. Drake
  • Nature Biomedical Engineering | News & Views

    Two drug-loaded nanoparticle formulations that preferentially accumulate within tumour-associated macrophages induce macrophage repolarization to a tumoricidal state that leads to potent antitumour activity in multiple murine models of cancer.

    • Heather H. Gustafson
    •  &  Suzie H. Pun

Methods & Protocols