A newly composed single-cell transcriptomic atlas of tumor-infiltrating T cells across 16 cancer types revealed previously undescribed T cell states and heterogeneity. A unique T cell stress response state, TSTR, was linked to immunotherapy resistance. Our high-resolution T cell reference maps, web portal, and annotation tool can assist efforts to develop T cell therapies.
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References
Zheng, L. et al. Pan-cancer single-cell landscape of tumor-infiltrating T cells. Science 374, abe6474 (2021). This is the first pan-cancer analysis of tumor-infiltrating T cells that describes the trajectories that lead to T cell exhaustion.
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This is a summary of: Chu, Y. et al. Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance. Nat. Med. https://doi.org/10.1038/s41591-023-02371-y (2023).
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Stress response in tumor-infiltrating T cells is linked to immunotherapy resistance. Nat Med 29, 1336–1337 (2023). https://doi.org/10.1038/s41591-023-02370-z
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DOI: https://doi.org/10.1038/s41591-023-02370-z
