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Gynaecological cancer

Mirvetuximab soravtansine has activity in platinum-sensitive epithelial ovarian cancer

Nature Reviews Clinical Oncology (2024)Cite this article

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Patients with recurrent, platinum-sensitive epithelial ovarian cancer (defined as disease relapse ≥6 months after first-line platinum-based chemotherapy) typically receive additional platinum-based regimens with or without bevacizumab, although most patients will have further relapse events. Now, data from one of the arms of the phase Ib FORWARD II trial show that the addition of the antibody–drug conjugate mirvetuximab soravtansine to carboplatin and bevacizumab has promising activity in patients with folate-receptor-α-positive (FRα+) disease.

A total of 41 women received triplet therapy. FRα positivity was defined as a score of ≥2 + in ≥50% of tumour cells as determined with the VENTANA FOLR1 RxDx immunohistochemistry assay; 49% and 51% of patients had FRα tumour expression levels ≥75% and 50–74%, respectively. Objective response rate (ORR) and safety were the co-primary end points.

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Original article

  • Richardson, D. L. et al. Phase 1b study of mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate, in combination with carboplatin and bevacizumab in patients with platinum-sensitive ovarian cancer. Gynecol. Oncol. 185, 186–193 (2024)

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  1. Nature Reviews Clinical Oncology http://www.nature.com/nrclinonc

    Diana Romero

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  1. Diana Romero
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Correspondence to Diana Romero.

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Romero, D. Mirvetuximab soravtansine has activity in platinum-sensitive epithelial ovarian cancer. Nat Rev Clin Oncol (2024). https://doi.org/10.1038/s41571-024-00888-w

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  • DOI: https://doi.org/10.1038/s41571-024-00888-w

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