Collection

Cancer at Nature Research

The Nature Research editors who handle cancer primary research, methods, protocols and reviews bring you the latest articles, covering all aspects from disease mechanisms to therapeutic approaches. Collected here you will also find specially curated content, such as collections, focus issues and animations, all ready to be used in presentations and educational materials. You can also find out about the editors handling cancer contents, and the journals at Nature Research that publish articles on this topic and how to submit to them.

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Research Articles

  • Nature | Article

    BRCA1, but not BRCA2, suppresses the formation of tandem duplications at stalled replication forks in primary mammalian cells.

    • Nicholas A. Willis
    • , Richard L. Frock
    • , Francesca Menghi
    • , Erin E. Duffey
    • , Arvind Panday
    • , Virginia Camacho
    • , E. Paul Hasty
    • , Edison T. Liu
    • , Frederick W. Alt
    •  &  Ralph Scully
  • Nature | Letter

    Cancers growing in high-oxygen environments, such as lung adenocarcinomas, select for the iron–sulfur cluster synthesizing enzyme NFS1 to support malignant proliferation and to protect from oxidative damage.

    • Samantha W. Alvarez
    • , Vladislav O. Sviderskiy
    • , Erdem M. Terzi
    • , Thales Papagiannakopoulos
    • , Andre L. Moreira
    • , Sylvia Adams
    • , David M. Sabatini
    • , Kıvanç Birsoy
    •  &  Richard Possemato
  • Nature Communications | Article | open

    Extracellular vesicles (EV)-associated RNAs are serum biomarkers potentially exploitable for early cancer diagnosis. Here the authors develop a catalyzed hairpin DNA circuit within a cationic lipid-polymer hybrid nanoparticle that can detect low–level EV-associated RNAs in early stage cancer patients.

    • Jiaming Hu
    • , Yan Sheng
    • , Kwang Joo Kwak
    • , Junfeng Shi
    • , Bohao Yu
    •  &  L. James Lee
  • Nature Communications | Article | open

    Cachexia is a metabolic syndrome leading to muscle and adipose tissue loss in majority of cancer patients. Here the authors show that, in a mouse model, BET inhibitor JQ1 counteracts muscle and adipose tissue wasting tempering cachexia and prolonging survival through a mechanism unrelated to tumour growth.

    • Marco Segatto
    • , Raffaella Fittipaldi
    • , Fabrizio Pin
    • , Roberta Sartori
    • , Kyung Dae Ko
    • , Hossein Zare
    • , Claudio Fenizia
    • , Gianpietro Zanchettin
    • , Elisa Sefora Pierobon
    • , Shinji Hatakeyama
    • , Cosimo Sperti
    • , Stefano Merigliano
    • , Marco Sandri
    • , Panagis Filippakopoulos
    • , Paola Costelli
    • , Vittorio Sartorelli
    •  &  Giuseppina Caretti
  • Nature Communications | Article | open

    Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression. Here the authors show that CHK1 loss or chemical inhibition impacts on normal B cell development, lymphomagenesis and cancer cell survival.

    • Fabian Schuler
    • , Johannes G. Weiss
    • , Silke E. Lindner
    • , Michael Lohmüller
    • , Sebastian Herzog
    • , Simon F. Spiegl
    • , Philipp Menke
    • , Stephan Geley
    • , Verena Labi
    •  &  Andreas Villunger
  • Nature Communications | Article | open

    Overriding cytarabine resistance in AML remains an unmet medical need. Here, the authors show that the CHK1 inhibitor GDC-0575 in combination with cytarabine and G-CSF has a significant anti-leukemic effect without toxicity to normal marrow stem and progenitor cells.

    • Alessandro Di Tullio
    • , Kevin Rouault-Pierre
    • , Ander Abarrategi
    • , Syed Mian
    • , William Grey
    • , John Gribben
    • , Aengus Stewart
    • , Elizabeth Blackwood
    •  &  Dominique Bonnet

Reviews

  • Nature Reviews Clinical Oncology | Review

    The receptor-tyrosine kinase RET has been identified as a potentially actionable driver of oncogenesis. Several multikinase inhibitors with activity against RET have been explored in the clinic, but have only modest efficacy in patients with thyroid cancers, mostly in those with RET mutations, or RET-rearranged lung cancers. Herein, the authors outline the aberrations in RET that contribute to tumorigenesis, review the current clinical data for inhibitors of this kinase, and discuss whether the limited clinical success achieved with these agents to date is attributable to the intractability of RET as a drug target or the lack of highly specific RET inhibitors.

    • Alexander Drilon
    • , Zishuo I. Hu
    • , Gillianne G. Y. Lai
    •  &  Daniel S. W. Tan
  • Nature Reviews Urology | Review

    In this Review, Woldu and colleagues describe the implications of Rho GTPase signalling aberrations in the development of malignancy, including urothelial carcinoma. This signalling pathway has the potential for therapeutic targeting in this disease, but much work is necessary before current laboratory-based research can be translated into the clinic.

    • Solomon L. Woldu
    • , Ryan C. Hutchinson
    • , Laura-Maria Krabbe
    • , Oner Sanli
    •  &  Vitaly Margulis
  • Nature Reviews Cancer | Review

    This Review by Dewhirst and Secomb describes the current understanding of drug transport to tumour cells and the progress that has been made in developing methods to enhance drug delivery.

    • Mark W. Dewhirst
    •  &  Timothy W. Secomb
  • Nature Reviews Drug Discovery | Review

    Janus kinases (JAKs) are essential signalling mediators downstream of many pro-inflammatory cytokines. Jakinibs — small-molecule inhibitors of JAKs — have gained traction as safe and efficacious options for the treatment of inflammation-driven pathologies. This Review discusses the biology, development and efficacy of jakinibs in the treatment of immune and inflammatory diseases.

    • Daniella M. Schwartz
    • , Yuka Kanno
    • , Alejandro Villarino
    • , Michael Ward
    • , Massimo Gadina
    •  &  John J. O'Shea
  • Nature Reviews Urology | Review

    Sfanos et al. discuss the potentially procarcinogenic role of prostatic infections and inflammation in prostate pathogenesis. They summarize findings that suggest that an aberrant microbiome together with an inflammatory microenvironment are involved in the initiation of prostate cancer precursor lesions.

    • Karen S. Sfanos
    • , Srinivasan Yegnasubramanian
    • , William G. Nelson
    •  &  Angelo M. De Marzo

News & Commentary

Methods & Protocols

  • Nature Methods | Article

    Combining each sgRNA with a unique molecular identifier in a genome-wide screen increases sensitivity and robustness in both positive and negative selection.

    • Georg Michlits
    • , Maria Hubmann
    • , Szu-Hsien Wu
    • , Gintautas Vainorius
    • , Elena Budusan
    • , Sergei Zhuk
    • , Thomas R Burkard
    • , Maria Novatchkova
    • , Martin Aichinger
    • , Yiqing Lu
    • , John Reece-Hoyes
    • , Roberto Nitsch
    • , Daniel Schramek
    • , Dominic Hoepfner
    •  &  Ulrich Elling
  • Nature Methods | Brief Communication

    SCENIC enables simultaneous regulatory network inference and robust cell clustering from single-cell RNA-seq data.

    • Sara Aibar
    • , Carmen Bravo González-Blas
    • , Thomas Moerman
    • , Vân Anh Huynh-Thu
    • , Hana Imrichova
    • , Gert Hulselmans
    • , Florian Rambow
    • , Jean-Christophe Marine
    • , Pierre Geurts
    • , Jan Aerts
    • , Joost van den Oord
    • , Zeynep Kalender Atak
    • , Jasper Wouters
    •  &  Stein Aerts
  • Nature Protocols | Protocol

    This massively parallel pipeline enables high-throughput generation and confirmation of variants by Gateway cloning, barcoding, and next-generation sequencing, and their stratification by multiplexed interaction profiling and experimental validation.

    • Song Yi
    • , Ning-Ning Liu
    • , Limei Hu
    • , Hui Wang
    •  &  Nidhi Sahni
  • Nature Protocols | Protocol

    In this protocol, the skull overlying the cerebellum is removed and a window is applied, enabling intravital imaging to provide a detailed characterization of dynamic processes in this region of the mouse brain.

    • Vasileios Askoxylakis
    • , Mark Badeaux
    • , Sylvie Roberge
    • , Ana Batista
    • , Ned Kirkpatrick
    • , Matija Snuderl
    • , Zohreh Amoozgar
    • , Giorgio Seano
    • , Gino B Ferraro
    • , Sampurna Chatterjee
    • , Lei Xu
    • , Dai Fukumura
    • , Dan G Duda
    •  &  Rakesh K Jain