Microbiology

Definition

Microbiology is the study of microscopic organisms, such as bacteria, viruses, archaea, fungi and protozoa. This discipline includes fundamental research on the biochemistry, physiology, cell biology, ecology, evolution and clinical aspects of microorganisms, including the host response to these agents.

Featured

Latest Research and Reviews

  • Research |

    Updates from the Human Microbiome Project analyse the largest known body-wide metagenomic profile of human microbiome personalization.

    • Jason Lloyd-Price
    • , Anup Mahurkar
    • , Gholamali Rahnavard
    • , Jonathan Crabtree
    • , Joshua Orvis
    • , A. Brantley Hall
    • , Arthur Brady
    • , Heather H. Creasy
    • , Carrie McCracken
    • , Michelle G. Giglio
    • , Daniel McDonald
    • , Eric A. Franzosa
    • , Rob Knight
    • , Owen White
    •  & Curtis Huttenhower
  • Research |

    Genome editing in human zygotes shows that OCT4 is required for normal development at an earlier stage in humans than in mice.

    • Norah M. E. Fogarty
    • , Afshan McCarthy
    • , Kirsten E. Snijders
    • , Benjamin E. Powell
    • , Nada Kubikova
    • , Paul Blakeley
    • , Rebecca Lea
    • , Kay Elder
    • , Sissy E. Wamaitha
    • , Daesik Kim
    • , Valdone Maciulyte
    • , Jens Kleinjung
    • , Jin-Soo Kim
    • , Dagan Wells
    • , Ludovic Vallier
    • , Alessandro Bertero
    • , James M. A. Turner
    •  & Kathy K. Niakan
  • Research | | open

    CRISPR-Cas9-based gene editing involves double-strand breaks at target sequences, which are often repaired by mutagenic non-homologous end-joining. Here the authors use Cas9 nickases to generate coordinated single-strand breaks in donor and target DNA for precise homology-directed gene editing.

    • Xiaoyu Chen
    • , Josephine M. Janssen
    • , Jin Liu
    • , Ignazio Maggio
    • , Anke E. J. ‘t Jong
    • , Harald M.M. Mikkers
    •  & Manuel A. F. V. Gonçalves
  • Research | | open

    Assembly of filamentous RSV particles is incompletely understood due to a lack of techniques suitable for live-cell imaging. Here Vanover et al. use labeled soybean agglutinin to selectively label RSV G protein and show how filamentous RSV assembly, initiated in the cytoplasm, uses G protein recycled from the plasma membrane.

    • Daryll Vanover
    • , Daisy V. Smith
    • , Emmeline L. Blanchard
    • , Eric Alonas
    • , Jonathan L. Kirschman
    • , Aaron W. Lifland
    • , Chiara Zurla
    •  & Philip J. Santangelo
  • Research | | open

    Zika virus infection can result in congenital disorders and cause disease in adults, and there is currently no approved vaccine. Here Shan et al. show that a single dose of a live-attenuated Zika vaccine prevents infection, testis damage and transmission to the fetus during pregnancy in different animal models.

    • Chao Shan
    • , Antonio E. Muruato
    • , Brett W. Jagger
    • , Justin Richner
    • , Bruno T. D. Nunes
    • , Daniele B. A. Medeiros
    • , Xuping Xie
    • , Jannyce G. C. Nunes
    • , Kaitlyn M. Morabito
    • , Wing-Pui Kong
    • , Theodore C. Pierson
    • , Alan D. Barrett
    • , Scott C. Weaver
    • , Shannan L. Rossi
    • , Pedro F. C. Vasconcelos
    • , Barney S. Graham
    • , Michael S. Diamond
    •  & Pei-Yong Shi

News and Comment