Cancer
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Definition
Cancer is a complex disease in which cells in a specific tissue are no longer fully responsive to the signals within the tissue that regulate cellular differentiation, survival, proliferation and death. As a result, these cells accumulate within the tissue, causing local damage and inflammation. There are over 200 different types of cancer.
News and Comment
Research Highlights
Gastrointestinal cancer: CROSS: new standard of care for oesophageal cancer
Lisa Hutchinson
Nature Reviews Clinical Oncology
doi:10.1038/nrclinonc.2015.143
News and Views
Subversion of anticancer immunosurveillance by radiotherapy
Laurence Zitvogel et al.
doi:10.1038/ni.3236
Up-front polytherapy for ALK-positive lung cancer
Bingying Zhou et al.
Nature Medicine 21, pages 974-975
doi:10.1038/nm.3942
Breast cancer: The debate over post-mastectomy radiotherapy should continue
Caspian Oliai et al.
Nature Reviews Clinical Oncology
doi:10.1038/nrclinonc.2015.147
Research and Reviews
Research
Stiff substrates increase YAP-signaling-mediated matrix metalloproteinase-7 expression
A Nukuda et al.
Oncogenesis 4, page e165
doi:10.1038/oncsis.2015.24
Oncogenesis 4, page e166
doi:10.1038/oncsis.2015.25
Forkhead box K2 modulates epirubicin and paclitaxel sensitivity through FOXO3a in breast cancer
G Nestal de Moraes et al.
Oncogenesis 4, page e167
doi:10.1038/oncsis.2015.26
CDKN1A regulates Langerhans cell survival and promotes Treg cell generation upon exposure to ionizing irradiation
Jeremy G Price et al.
doi:10.1038/ni.3270
doi:10.1038/nmeth.3578
Reviews
Dissecting fibrosis: therapeutic insights from the small-molecule toolbox
Carmel B. Nanthakumar et al.
Nature Reviews Drug Discovery 14, pages 642-662
doi:10.1038/nrd4663
doi:10.1038/nrurol.2015.206
Nature Reviews Clinical Oncology
doi:10.1038/nrclinonc.2015.140
Nature Reviews Disease Primers
doi:10.1038/nrdp.2015.21
Modern approaches to HLA-haploidentical blood or marrow transplantation
Christopher G. Kanakry et al.
Nature Reviews Clinical Oncology
doi:10.1038/nrclinonc.2015.128
Nature Reviews Cancer 15, pages 563-572
doi:10.1038/nrc3978
Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes
A Sveen et al.
doi:10.1038/onc.2015.318
Protocols
An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis
Thomas Reiberger et al.
Nature Protocols 10, pages 1264-1274
doi:10.1038/nprot.2015.080
doi:10.1038/bonekey.2015.37
Design of a functional cyclic HSV1-TK reporter and its application to PET imaging of apoptosis
Zhe Wang et al.
Nature Protocols 10, pages 807-821
doi:10.1038/nprot.2015.048
Nature Protocols 9, pages 2880-2902
doi:10.1038/nprot.2014.185
Nature Protocols 9, pages 2682-2692
doi:10.1038/nprot.2014.178
Establishing a human renal cell carcinoma tumorgraft platform for preclinical drug testing
Andrea Pavía-Jiménez et al.
Nature Protocols 9, pages 1848-1859
doi:10.1038/nprot.2014.108
Microfluidic, marker-free isolation of circulating tumor cells from blood samples
Nezihi Murat Karabacak et al.
Nature Protocols 9, pages 694-710
doi:10.1038/nprot.2014.044
Determining the macropinocytic index of cells through a quantitative image-based assay
Cosimo Commisso et al.
Nature Protocols 9, pages 182-192
doi:10.1038/nprot.2014.004
Simultaneous isolation of high-quality DNA, RNA, miRNA and proteins from tissues for genomic applications
Samuel Peña-Llopis et al.
Nature Protocols 8, pages 2240-2255
doi:10.1038/nprot.2013.141
Amendments and Corrections
doi:10.1038/srep13328
doi:10.1038/nature14959
Corrigendum: Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D3-MARRS
Chihiro Tohda et al.
doi:10.1038/srep12660
Corrigendum: DW-F5: A novel formulation against malignant melanoma from Wrightia tinctoria
Jayesh Antony et al.
doi:10.1038/srep12662
Erratum: A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer
Nada A. Al-Tassan et al.
doi:10.1038/srep12372
Erratum: Unraveling novel TF-miRNA regulatory crosstalk in metastasis of Soft Tissue Sarcoma
Devyani Samantarrai et al.
doi:10.1038/srep12254
Nature Events Directory
The 2015 Tissue Engineering Congress
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Peninsula Square , London, United Kingdom
Metabolism in Cancer and Stromal Cells
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Leopold Vanderkelenstraat 28, 3000 , Leuven, Belgium
Metabolism in Cancer and Stromal Cells
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Leopold Vanderkelenstraat 28, 3000, Leuven, Belgium
Comments and Opinion
HPV-FASTER: broadening the scope for prevention of HPV-related cancer
F. Xavier Bosch et al.
Nature Reviews Clinical Oncology
Why is it hard to terminate failing projects in pharmaceutical R&D?
Richard W. Peck et al.
Nature Reviews Drug Discovery
Optimizing early upper gastrointestinal cancer detection at endoscopy
Andrew M. Veitch et al.
Nature Reviews Gastroenterology and Hepatology
Does surgery have a role in managing incurable gastric cancer?
Sri G. Thrumurthy et al.
Nature Reviews Clinical Oncology
Stem cell divisions and cancer
P J Quesenberry et al.
Leukemia
First-line chemotherapy for mCRC—a review and evidence-based algorithm
Chiara Cremolini et al.
Nature Reviews Clinical Oncology
Probing the epigenome
Andrea Huston et al.
Nature Chemical Biology
Outcomes of treatment with stereotactic radiosurgery or proton beam therapy for choroidal melanoma
M J Sikuade et al.
Eye
Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading
Pavel Strop et al.
Nature Biotechnology