Ten Year Anniversary Special

Ten years of Methods - p973

doi:10.1038/nmeth.3141

The decade since the launch of Nature Methods has been one of intense and dynamic development in biological research methods. We predict this will continue.

Abstract - Ten years of Methods | Full Text - Ten years of Methods | PDF (89 KB) - Ten years of Methods

Ten Year Anniversary Special

Ten years of Methods - pp1000 - 1001

doi:10.1038/nmeth1014-1000

Our choice, among many candidates, of the ten areas of methods development with the most impact on biological research over the last decade. Visit Methagora to browse Nature Methods papers in some of these areas.

Abstract - Ten years of Methods | Full Text - Ten years of Methods | PDF (1,473 KB) - Ten years of Methods

Ten Year Anniversary Special

A defining decade in DNA sequencing - pp1003 - 1005

John D McPherson

doi:10.1038/nmeth.3106

A revolution in DNA sequencing technology has enabled new insights from thousands of genomes sequenced across taxa.

Abstract - A defining decade in DNA sequencing | Full Text - A defining decade in DNA sequencing | PDF (3,716 KB) - A defining decade in DNA sequencing

Ten Year Anniversary Special

The fate of cell reprogramming - pp1006 - 1008

Peter Karagiannis & Shinya Yamanaka

doi:10.1038/nmeth.3109

The ability to convert somatic cells to induced pluripotent stem cells has immense potential to further our understanding of development and disease mechanisms, and for cellular therapy. Before researchers can achieve these goals, they must expand current methodology to incorporate animal models and quantitative descriptions of the essential phenomena driving reprogramming.

Abstract - The fate of cell reprogramming | Full Text - The fate of cell reprogramming | PDF (218 KB) - The fate of cell reprogramming

Ten Year Anniversary Special

Genome engineering: the next genomic revolution - pp1009 - 1011

Charles A Gersbach

doi:10.1038/nmeth.3113

A decade of advances in genome engineering technologies has enabled the editing of genome sequences much like one edits computer code; many more applications for precisely manipulating genome structure and function are on the horizon.

Abstract - Genome engineering: the next genomic revolution | Full Text - Genome engineering: the next genomic revolution | PDF (617 KB) - Genome engineering: the next genomic revolution

Ten Year Anniversary Special

Optogenetics: the age of light - pp1012 - 1014

Michael Häusser

doi:10.1038/nmeth.3111

The optogenetic revolution is transforming neuroscience. The dramatic recent progress in using light to both control and read out neural activity has highlighted the need for better probes, improved light delivery and more careful interpretation of results, which will all be required for optogenetics to fully realize its remarkable potential.

Abstract - Optogenetics: the age of light | Full Text - Optogenetics: the age of light | PDF (1,249 KB) - Optogenetics: the age of light

Ten Year Anniversary Special

Single-molecule methods leap ahead - pp1015 - 1018

Taekjip Ha

doi:10.1038/nmeth.3107

Much of our knowledge about biological systems has been obtained by examining ensembles of molecules. However, this has begun to change because of the unprecedented precision and clarity afforded by single-molecule measurements. The last decade has seen amazing advances in the resolution and complexity of these methods, making it possible to ask and answer entirely new types of biological questions.

Abstract - Single-molecule methods leap ahead | Full Text - Single-molecule methods leap ahead | PDF (432 KB) - Single-molecule methods leap ahead