Image: Sölvi Hrafn Ingimundarson and the Human Protein Atlas. Design: Erin Dewalt

Genome model captures variation

Reducing read mapping bias and improving complex variant detection with a highly scalable computational toolkit that implements variation graphs.

Latest Research

  • Article |

    A wild tomato species is domesticated by targeted CRISPR–Cas9 editing of just six genes.

    • Agustin Zsögön
    • , Tomáš Čermák
    • , Emmanuel Rezende Naves
    • , Marcela Morato Notini
    • , Kai H Edel
    • , Stefan Weinl
    • , Luciano Freschi
    • , Daniel F Voytas
    • , Jörg Kudla
    •  & Lázaro Eustáquio Pereira Peres
  • Perspective |

    Machine learning and natural language processing methods are applied to learn from PubMed searches and improve user experience.

    • Nicolas Fiorini
    • , Robert Leaman
    • , David J Lipman
    •  & Zhiyong Lu
  • Brief Communication |

    Precise genome engineering of a handful of genes enables rapid domestication of wild tomato plants.

    • Tingdong Li
    • , Xinping Yang
    • , Yuan Yu
    • , Xiaomin Si
    • , Xiawan Zhai
    • , Huawei Zhang
    • , Wenxia Dong
    • , Caixia Gao
    •  & Cao Xu
  • Letter |

    A benchtop system for protein synthesis achieves purity and potency comparable to those of marketed drugs.

    • Laura E Crowell
    • , Amos E Lu
    • , Kerry R Love
    • , Alan Stockdale
    • , Steven M Timmick
    • , Di Wu
    • , Yu (Annie) Wang
    • , William Doherty
    • , Alexandra Bonnyman
    • , Nicholas Vecchiarello
    • , Chaz Goodwine
    • , Lisa Bradbury
    • , Joseph R Brady
    • , John J Clark
    • , Noelle A Colant
    • , Aleksandar Cvetkovic
    • , Neil C Dalvie
    • , Diana Liu
    • , Yanjun Liu
    • , Craig A Mascarenhas
    • , Catherine B Matthews
    • , Nicholas J Mozdzierz
    • , Kartik A Shah
    • , Shiaw-Lin Wu
    • , William S Hancock
    • , Richard D Braatz
    • , Steven M Cramer
    •  & J Christopher Love
  • Letter |

    DeepVariant uses convolutional neural networks to improve the accuracy of variant calling.

    • Ryan Poplin
    • , Pi-Chuan Chang
    • , David Alexander
    • , Scott Schwartz
    • , Thomas Colthurst
    • , Alexander Ku
    • , Dan Newburger
    • , Jojo Dijamco
    • , Nam Nguyen
    • , Pegah T Afshar
    • , Sam S Gross
    • , Lizzie Dorfman
    • , Cory Y McLean
    •  & Mark A DePristo

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