Image: Sölvi Hrafn Ingimundarson and the Human Protein Atlas. Design: Erin Dewalt

Genome model captures variation

Reducing read mapping bias and improving complex variant detection with a highly scalable computational toolkit that implements variation graphs.

Latest Research

Article | 01 October 2018

De novo domestication of wild tomato using genome editing

A wild tomato species is domesticated by targeted CRISPR–Cas9 editing of just six genes.
- Agustin Zsögön
- , Tomáš Čermák
- , Emmanuel Rezende Naves
- , Marcela Morato Notini
- , Kai H Edel
- , Stefan Weinl
- , Luciano Freschi
- , Daniel F Voytas
- , Jörg Kudla
- & Lázaro Eustáquio Pereira Peres
Brief Communication | 01 October 2018

Efficient C-to-T base editing in plants using a fusion of nCas9 and human APOBEC3A

A base editor containing a human cytidine deaminase offers a larger editing window.
- Yuan Zong
- , Qianna Song
- , Chao Li
- , Shuai Jin
- , Dingbo Zhang
- , Yanpeng Wang
- , Jin-Long Qiu
- & Caixia Gao
Perspective | 01 October 2018

How user intelligence is improving PubMed

Machine learning and natural language processing methods are applied to learn from PubMed searches and improve user experience.
- Nicolas Fiorini
- , Robert Leaman
- , David J Lipman
- & Zhiyong Lu
Brief Communication | 01 October 2018

Domestication of wild tomato is accelerated by genome editing

Precise genome engineering of a handful of genes enables rapid domestication of wild tomato plants.
- Tingdong Li
- , Xinping Yang
- , Yuan Yu
- , Xiaomin Si
- , Xiawan Zhai
- , Huawei Zhang
- , Wenxia Dong
- , Caixia Gao
- & Cao Xu
Letter | 01 October 2018

On-demand manufacturing of clinical-quality biopharmaceuticals

A benchtop system for protein synthesis achieves purity and potency comparable to those of marketed drugs.
- Laura E Crowell
- , Amos E Lu
- , Kerry R Love
- , Alan Stockdale
- , Steven M Timmick
- , Di Wu
- , Yu (Annie) Wang
- , William Doherty
- , Alexandra Bonnyman
- , Nicholas Vecchiarello
- , Chaz Goodwine
- , Lisa Bradbury
- , Joseph R Brady
- , John J Clark
- , Noelle A Colant
- , Aleksandar Cvetkovic
- , Neil C Dalvie
- , Diana Liu
- , Yanjun Liu
- , Craig A Mascarenhas
- , Catherine B Matthews
- , Nicholas J Mozdzierz
- , Kartik A Shah
- , Shiaw-Lin Wu
- , William S Hancock
- , Richard D Braatz
- , Steven M Cramer
- & J Christopher Love
Letter | 24 September 2018

A universal SNP and small-indel variant caller using deep neural networks

DeepVariant uses convolutional neural networks to improve the accuracy of variant calling.
- Ryan Poplin
- , Pi-Chuan Chang
- , David Alexander
- , Scott Schwartz
- , Thomas Colthurst
- , Alexander Ku
- , Dan Newburger
- , Jojo Dijamco
- , Nam Nguyen
- , Pegah T Afshar
- , Sam S Gross
- , Lizzie Dorfman
- , Cory Y McLean
- & Mark A DePristo

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News & Comment

News | 06 September 2018

Verily project releases millions of factory-reared mosquitoes
- Judith A Gilbert
- & Lisa Melton
Careers and Recruitment | 06 September 2018

Personalized postdoctoral fellowship care

Adapting the clinical residency training model can help postdoctoral research fellows navigate and personalize their training experience for their unique career goals.
- Mindy Kim Graham
- , Ben Ho Park
- & Nicolas Wyhs
Podcast | 06 September 2018

PODCAST: First rounders: Feng Zhang
News | 06 September 2018

Around the world in a month
Patents | 06 September 2018

Analyzing the protection scope limit for biosequence patent claims in China

Though a patent's protection scope should be based on the content of the claims and written description, determining the protection scope of a biosequence patent has always been a controversial issue in practice.
- Wei Li
Commentary | 06 September 2018

Brain leaks and consumer neurotechnology

Greater safeguards are needed to address the personal safety, security and privacy risks arising from increasing adoption of neurotechnology in the consumer realm.
- Marcello Ienca
- , Pim Haselager
- & Ezekiel J Emanuel

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Nature events Directory

Naturejobs Career Expo London 2018

04 October 2018 – 04 October 2018

52 Upper Street, London N1 0QH, UK, United Kingdom
Probabilistic Modeling in Genomics

04 November 2018 – 07 November 2018

Cold Spring Harbor, United States
VII Congress and Associate Symposiums of Vavilov Society of Geneticists and Breeders

18 June 2019 – 22 June 2019

109, Saint Petersburg highway, Petergof, Saint Petersburg, Russian Federation
Medicinal Chemistry Strategy Meeting US West Coast 2018

30 October 2018 – 30 October 2018

1333 Old Bayshore Highway, Burlingame, United States
EMBL Course: Bioinformatics for Plant Biology

05 November 2018 – 09 November 2018

Hinxton, United Kingdom

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Genome model captures variation

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Latest Research

De novo domestication of wild tomato using genome editing

Efficient C-to-T base editing in plants using a fusion of nCas9 and human APOBEC3A

How user intelligence is improving PubMed

Domestication of wild tomato is accelerated by genome editing

On-demand manufacturing of clinical-quality biopharmaceuticals

A universal SNP and small-indel variant caller using deep neural networks

News & Comment

Verily project releases millions of factory-reared mosquitoes

Personalized postdoctoral fellowship care

PODCAST: First rounders: Feng Zhang

Around the world in a month

Analyzing the protection scope limit for biosequence patent claims in China

Brain leaks and consumer neurotechnology

Journal tools

A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes

Conversion of staphylococcal pathogenicity islands to CRISPR-carrying antibacterial agents that cure infections in mice

De novo domestication of wild tomato using genome editing

A universal SNP and small-indel variant caller using deep neural networks

Naturejobs.com

Post-doctoral Fellowships and Research Assistant Professorships

2018-2019 Faculty and Postdoc Positions at the iHuman Institute, ShanghaiTech University

Jobs Opening at Hong Kong Baptist University

Chair in Melanoma Discovery

Postdoctoral (Scholarship) in Real-time Sensing of In vitro Neural Systems

Nature events Directory

Naturejobs Career Expo London 2018

Probabilistic Modeling in Genomics

VII Congress and Associate Symposiums of Vavilov Society of Geneticists and Breeders

Medicinal Chemistry Strategy Meeting US West Coast 2018

EMBL Course: Bioinformatics for Plant Biology

Genome model captures variation

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