Focuses and supplements
Nature Methods provides reviews and commentary illuminating topics of particular interest. These sites also contain annotated lists of classic papers, updated research notes and links to related material.
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2009

Next-generation sequencing data analysis -
A commissioned Commentary discusses the strength and challenges of next-generation sequencing, and a series of commissioned Reviews explain the principles behind data-analysis software for important applications from alignment and assembly to structural-variant detection and the interpretation of ChIP-seq and RNA-seq data.
October Vol. 6, No. 11s

Special Feature - Five Year Anniversary Special -
Nature Methods celebrates its five year anniversary with commentaries discussing the impact and progress of methodological developments in the life sciences. We also include a fun selection of papers and covers from our pages.
October Vol. 6, No. 10

Special Feature - Method of the Year 2008 -
Nature Methods' Method of the Year 2008 goes to super-resolution fluorescence microscopy. This series of articles—and the related movie—showcase how these novel imaging methods came into their own in 2008 and the incredible impact they promise to have in biological research. The Methods to Watch feature provides a glimpse of future Methods of the Year and the Reader's Choice shows methods nominated by readers and editors, and the votes that they received.
January Vol. 6, No. 1
2008

Focus on Single-Molecule Analysis -
Specially commissioned Reviews and a Perspective provide a guide to the maturing field of single-molecule analysis and two original research papers describe complementary advances in nanoscale visualization.
June Vol. 5, No. 6

Special Feature - Method of the Year 2007 -
Nature Methods' Method of the Year 2007 goes to next-generation sequencing. This series of articles showcase how these novel sequencing methods came into their own in 2007 and the incredible impact they promise to have in a variety of research applications. The Methods to Watch feature provide a glimpse and a wish list for future Methods of the Year.
January Vol. 5, No. 1
2007

Focus on mass spectrometry in proteomics -
A series of specially commissioned Commentaries, Reviews and Perspectives discuss the use of mass spectrometry in established approaches to proteomics as well as emerging technologies.
October Vol. 4, No. 10
2006

Focus on RNA interference - A user's guide -
Eight especially commissioned Perspective articles that discuss practical questions surrounding the use of RNA interference in mammalian cells, as a tool to knock down a specific gene of interest and as a resource for functional genomics screens.
September Vol. 3, No. 9
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2005

Fluorescence Imaging -
A series of review articles and other content discussing the principles of fluorescence and different imaging modalities along with practical advice.
December Vol. 2, No. 12
