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doi:10.1038/ncomms14132

Welcome to Nature Communications

Nature Communications is an open access journal that publishes high-quality research in biology, physics, chemistry, Earth sciences, and all related areas.

Browse Articles

  • Article | | open

    Despite being structurally similar, the insulin receptor (IR) and insulin growth factor I receptor (IGF1R) elicit distinct signalling pathways. Here the authors use receptor chimeras to unveil that IR and IGF1R signalling is related primarily to differences in their intracellular juxtamembrane region.

    • Weikang Cai
    • , Masaji Sakaguchi
    • , Andre Kleinridders
    • , Gonzalo Gonzalez-Del Pino
    • , Jonathan M. Dreyfuss
    • , Brian T. O’Neill
    • , Alfred K. Ramirez
    • , Hui Pan
    • , Jonathon N. Winnay
    • , Jeremie Boucher
    • , Michael J. Eck
    •  & C. Ronald Kahn
  • Article | | open

    Zika virus infection can cause human birth defects and Guillain-Barré syndrome. Here the authors present the structures of the full-length nonstructural protein 5 and its RNA-dependent RNA polymerase domain of Zika virus, which are targets for inhibitors of virus replication.

    • Baoyu Zhao
    • , Guanghui Yi
    • , Fenglei Du
    • , Yin-Chih Chuang
    • , Robert C. Vaughan
    • , Banumathi Sankaran
    • , C. Cheng Kao
    •  & Pingwei Li
  • Article | | open

    Hair can be regenerated after skin wounding. Here the authors show that inflammatory macrophages produce TNF that activates Wnt signalling in hair follicle stem cells to drive this hair regeneration after wound repair in mice.

    • Xusheng Wang
    • , Haiyan Chen
    • , Ruiyun Tian
    • , Yiling Zhang
    • , Marina S. Drutskaya
    • , Chengmei Wang
    • , Jianfeng Ge
    • , Zhimeng Fan
    • , Deqiang Kong
    • , Xiaoxiao Wang
    • , Ting Cai
    • , Ying Zhou
    • , Jingwen Wang
    • , Jinmei Wang
    • , Shan Wang
    • , Zhihai Qin
    • , Huanhuan Jia
    • , Yue Wu
    • , Jia Liu
    • , Sergei A. Nedospasov
    • , Edward E. Tredget
    • , Mei Lin
    • , Jianjun Liu
    • , Yuyang Jiang
    •  & Yaojiong Wu
  • Article | | open

    Anti-PD-L1 therapy often fails in cancers with minimal lymphocytic infiltrates and low PD-L1 expression. Here, the authors show that an oncolytic virus increases PD-L1 expression in cancer models and that the combination with an anti-PD-L1 antibody enhances therapy by increasing the infiltration of activated T cells, and reducing exhausted T cells.

    • Zuqiang Liu
    • , Roshni Ravindranathan
    • , Pawel Kalinski
    • , Z. Sheng Guo
    •  & David L. Bartlett
  • Article | | open

    Recently, fabrication processes have realised three-dimensional nanoporous graphene. Here, the authors reveal two-dimensional Dirac plasmons in three-dimensional nanoporous graphene disclosing strong plasmonic absorptions tunable from terahertz to mid-infrared via controllable doping level and porosity.

    • Fausto D’Apuzzo
    • , Alba R. Piacenti
    • , Flavio Giorgianni
    • , Marta Autore
    • , Mariangela Cestelli Guidi
    • , Augusto Marcelli
    • , Ulrich Schade
    • , Yoshikazu Ito
    • , Mingwei Chen
    •  & Stefano Lupi

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