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Nature Communications is an open access journal that publishes high-quality research in biology, physics, chemistry, Earth sciences, and all related areas.

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  • Article | | open

    Functions of the embryonic brain prior to regulating behavior are unclear. Here, the authors use an amputation assay in Xenopus laevis to demonstrate that removal of the brain early in development alters muscle and peripheral nerve patterning, which can be rescued by modulating bioelectric signals.

    • Celia Herrera-Rincon
    • , Vaibhav P. Pai
    • , Kristine M. Moran
    • , Joan M. Lemire
    •  & Michael Levin
  • Article | | open

    Several metabolic factors affect cellular glucose metabolism as well as the innate inflammatory response. Here, the authors show that glucose metabolism regulates pro-inflammatory responses through effects on the cytosolic NADH:NAD+ ratio and the NAD(H)-sensitive transcription co-repressor CtBP.

    • Yiguo Shen
    • , David Kapfhamer
    • , Angela M. Minnella
    • , Ji-Eun Kim
    • , Seok Joon Won
    • , Yanting Chen
    • , Yong Huang
    • , Ley Hian Low
    • , Stephen M. Massa
    •  & Raymond A. Swanson
  • Article | | open

    In prostate cancer, the role of mutations in the maternally-inherited mitochondrial genome are not well known. Here, the authors demonstrate frequent, age-dependent mitochondrial mutation in prostate cancer. Strong links between mitochondrial and nuclear mutational profiles are associated with clinical aggressivity.

    • Julia F. Hopkins
    • , Veronica Y. Sabelnykova
    • , Joachim Weischenfeldt
    • , Ronald Simon
    • , Jennifer A. Aguiar
    • , Rached Alkallas
    • , Lawrence E. Heisler
    • , Junyan Zhang
    • , John D. Watson
    • , Melvin L. K. Chua
    • , Michael Fraser
    • , Francesco Favero
    • , Chris Lawerenz
    • , Christoph Plass
    • , Guido Sauter
    • , John D. McPherson
    • , Theodorus Kwast
    • , Jan Korbel
    • , Thorsten Schlomm
    • , Robert G. Bristow
    •  & Paul C. Boutros
  • Article | | open

    Spintronic devices with full electrical control rely on electrical generation and detection of spin currents in the absence of magnetic materials. Here, the authors use Pt, a non-magnetic metal, to generate and detect pure spin currents in a few-layer graphene channel, achieving a remarkable spin-to-charge voltage signal at room temperature.

    • Wenjing Yan
    • , Edurne Sagasta
    • , Mário Ribeiro
    • , Yasuhiro Niimi
    • , Luis E. Hueso
    •  & Fèlix Casanova
  • Article | | open

    O-linked β-N-acetyl glucosamine (O-GlcNAc) is an important protein modification that is hydrolyzed by O-GlcNAcase (OGA). Here the authors give insights into OGA substrate recognition by presenting four human OGA structures complexed with glycopeptide substrates containing a single O-GlcNAc modification on either a serine or threonine.

    • Baobin Li
    • , Hao Li
    • , Chia-Wei Hu
    •  & Jiaoyang Jiang
  • Article | | open

    The development of future computation devices will be aided by a better understanding of the physics underlying material behaviors. Using thermoreflectance and spatially resolved X-ray microscopy, Kumar et al. elucidate the origin of two types of negative differential resistance in NbO2 memristors.

    • Suhas Kumar
    • , Ziwen Wang
    • , Noraica Davila
    • , Niru Kumari
    • , Kate J. Norris
    • , Xiaopeng Huang
    • , John Paul Strachan
    • , David Vine
    • , A.L. David Kilcoyne
    • , Yoshio Nishi
    •  & R. Stanley Williams

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