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Read the October issue of Nature Chemical Biology.

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News & Comment

  • Commentary |

    Selection of molecular targets based on disease understanding is a dominant paradigm in drug discovery. We argue that a focus on classes of targets with central roles in biology provides a complementary approach that has higher quality outcomes in early discovery efforts.

    • Kimberly D Barnash
    • , Lindsey I James
    •  & Stephen V Frye
  • News and Views |

    The introduction of a cyclopropyl group is critical for imparting colibactin with the ability to cleave DNA. Nonribosomal peptide synthetase ClbH and polyketide synthase ClbI are now shown to work in concert to convert S-adenosylmethionine into this cyclopropyl group.

    • Steven G Van Lanen
  • News and Views |

    Genome mining reveals a new ribosomally synthesized and post-translationally modified peptide (RiPP) from Klebsiella pneumoniae. This new antibiotic inhibits bacterial ribosomes by obstructing the peptide exit tunnel, and its modular nature presents a unique opportunity for future engineering of antibacterial drugs.

    • Ha An Nguyen
    •  & Christine M Dunham

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