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Hypoxia-inducible factor 3α1 increases epithelial-to-mesenchymal transition and iron uptake to drive colorectal cancer liver metastasis
- Luke B. Villareal
- , Daniel M. Falcon
- & Xiang Xue
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| Open AccessWhat can hospital emergency admissions prior to cancer diagnosis tell us about socio-economic inequalities in cancer diagnosis? Evidence from population-based data in England
- Aimilia Exarchakou
- , Bernard Rachet
- & Francisco Javier Rubio
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| Open AccessFirst-line oxaliplatin-based chemotherapy and nivolumab for metastatic microsatellite-stable colorectal cancer—the randomised METIMMOX trial
- Anne Hansen Ree
- , Jūratė Šaltytė Benth
- & Sebastian Meltzer
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Correspondence |
Comment on: “Neoadjuvant chemotherapy is noninferior to chemoradiotherapy for early-onset locally advanced rectal cancer in the FOWARC trial”
- Letian Qiao
- , Yuan Liu
- & Qiumin Yang
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| Open AccessGenetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk
- Yu Tian
- , Yi Lin
- & Jenny Chang-Claude
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| Open AccessIdentification of unique rectal cancer-specific subtypes
- Batuhan Kisakol
- , Anna Matveeva
- & Jochen H. M. Prehn
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Functional proteomics of colon cancer Consensus Molecular Subtypes
- Jaime Feliu
- , Angelo Gámez-Pozo
- & Lucía Trilla-Fuertes
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| Open AccessCirculating 25-hydroxyvitamin D and survival outcomes of colorectal cancer: evidence from population-based prospective cohorts and Mendelian randomisation
- Xiaomeng Zhang
- , Yazhou He
- & Malcolm G. Dunlop
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| Open AccessInhibition of the AURKA/YAP1 axis is a promising therapeutic option for overcoming cetuximab resistance in colorectal cancer stem cells
- Anxo Rio-Vilariño
- , Aiora Cenigaonandia-Campillo
- & Arancha Cebrián
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| Open AccessFluoropyrimidine type, patient age, tumour sidedness and mutation status as determinants of benefit in patients with metastatic colorectal cancer treated with EGFR monoclonal antibodies: individual patient data pooled analysis of randomised trials from the ARCAD database
- C. S. Karapetis
- , H. Liu
- & Q. Shi
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| Open AccessInhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells
- Esha T. Shah
- , Christopher Molloy
- & Mark N. Adams
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Predicting 5-year recurrence risk in colorectal cancer: development and validation of a histology-based deep learning approach
- Han Xiao
- , Zongpeng Weng
- & Sui Peng
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Dynamic nature of BRAF or KRAS p.G12C mutations in second-line therapy for advanced colorectal cancer patients: do early and late effects exist?
- Débora Contreras-Toledo
- , Paula Jiménez-Fonseca
- & Alberto Carmona-Bayonas
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| Open AccessGenome-wide polygenic risk scores for colorectal cancer have implications for risk-based screening
- Max Tamlander
- , Bradley Jermy
- & Nina Mars
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Association between weight cycling and risk of colorectal cancer: a prospective cohort study
- Suryun Kim
- , Dong Hoon Lee
- & NaNa Keum
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Stromal localization of inactive CD8+ T cells in metastatic mismatch repair deficient colorectal cancer
- Emre Küçükköse
- , Matthijs J. D. Baars
- & Yvonne Vercoulen
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| Open AccessOpposing roles by KRAS and BRAF mutation on immune cell infiltration in colorectal cancer – possible implications for immunotherapy
- Sofia Edin
- , Björn Gylling
- & Richard Palmqvist
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| Open AccessEfficacy and quality of life for FOLFOX/bevacizumab +/− irinotecan in first-line metastatic colorectal cancer—final results of the AIO CHARTA trial
- Hans-Joachim Schmoll
- , Julia Mann
- & Joseph Tintelnot
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APC/PIK3CA mutations and β-catenin status predict tankyrase inhibitor sensitivity of patient-derived colorectal cancer cells
- Mingjue Chen
- , Tetsuo Mashima
- & Hiroyuki Seimiya
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Preoperative chemoradiotherapy induces multiple pathways related to anti-tumour immunity in rectal cancer
- Ioannis M. Koukourakis
- , Erasmia Xanthopoulou
- & Anna Zygogianni
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Vitamin C intake and colorectal cancer survival according to KRAS and BRAF mutation: a prospective study in two US cohorts
- Shanshan Shi
- , Kai Wang
- & Mingyang Song
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Mismatch Repair system protein deficiency as a resistance factor for locally advanced rectal adenocarcinoma patients receiving neoadjuvant chemo-radiotherapy
- Andrea Pretta
- , Pina Ziranu
- & Mario Scartozzi
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Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers
- Yuta Kobayashi
- , Atsushi Niida
- & Koshi Mimori
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| Open AccessHistopathology and levels of proteins in plasma associate with survival after colorectal cancer diagnosis
- Magnus I. Magnusson
- , Bjarni A. Agnarsson
- & Kari Stefansson
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Combined blockade of mTOR and p21-activated kinases pathways prevents tumour growth in KRAS-mutated colorectal cancer
- Stefania Belli
- , Ada Pesapane
- & Roberto Bianco
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Review Article
| Open AccessAdvancing translational research for colorectal immuno-oncology
- Elaine M. Thomas
- , Josephine A. Wright
- & Susan L. Woods
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An MRI-based scoring system for pretreatment risk stratification in locally advanced rectal cancer
- Minning Zhao
- , Lili Feng
- & Zaiyi Liu
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A comprehensive appraisal of HER2 heterogeneity in HER2-amplified and HER2-low colorectal cancer
- Taiki Hashimoto
- , Daisuke Takayanagi
- & Shigeki Sekine
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Diagnostic yield of a risk model versus faecal immunochemical test only: a randomised controlled trial in a colorectal cancer screening programme
- Tim L. Kortlever
- , Manon van der Vlugt
- & Evelien Dekker
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| Open AccessThe underestimated impact of excess body weight on colorectal cancer risk: Evidence from the UK Biobank cohort
- Fatemeh Safizadeh
- , Marko Mandic
- & Hermann Brenner
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| Open AccessColorectal cancer detected by liquid biopsy 2 years prior to clinical diagnosis in the HUNT study
- Siv S. Brenne
- , Poul Henning Madsen
- & Eivor A. Laugsand
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| Open AccessProbing the diabetes and colorectal cancer relationship using gene – environment interaction analyses
- Niki Dimou
- , Andre E. Kim
- & Ulrike Peters
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| Open AccessPersonalised circulating tumour DNA assay with large-scale mutation coverage for sensitive minimal residual disease detection in colorectal cancer
- Seung-Bum Ryoo
- , Sunghoon Heo
- & Tae-You Kim
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Sleep and cancer recurrence and survival in patients with resected Stage III colon cancer: findings from CALGB/SWOG 80702 (Alliance)
- Seohyuk Lee
- , Chao Ma
- & Jeffrey A. Meyerhardt
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| Open AccessImmunological and prognostic significance of tumour necrosis in colorectal cancer
- Meeri Kastinen
- , Päivi Sirniö
- & Juha P. Väyrynen
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Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations throughout the life course and risk of colorectal cancer precursors
- Shuqi Zhang
- , Jinhee Hur
- & Edward Giovannucci
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| Open AccessSpatially resolved multimarker evaluation of CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint expression and macrophage polarisation in colorectal cancer
- Hanna Elomaa
- , Maarit Ahtiainen
- & Juha P. Väyrynen
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Review Article
| Open AccessLiver transplantation in metastatic colorectal cancer: are we ready for it?
- Javier Ros
- , Francesc Salva
- & Elena Elez
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Article
| Open AccessCancer-specific tissue-resident memory T-cells express ZNF683 in colorectal cancer
- Masatoshi Kitakaze
- , Mamoru Uemura
- & Hideshi Ishii
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A DNA methylation signature for the prediction of tumour recurrence in stage II colorectal cancer
- Min Li
- , Congcong Zhu
- & Qihong Huang
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An antibody–drug conjugate targeting GPR56 demonstrates efficacy in preclinical models of colorectal cancer
- Joan Jacob
- , Liezl E. Francisco
- & Kendra S. Carmon
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Trop-2 and Nectin-4 immunohistochemical expression in metastatic colorectal cancer: searching for the right population for drugs’ development
- Roberto Moretto
- , Marco Maria Germani
- & Chiara Cremolini
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| Open AccessSomatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens
- Takamasa Ishino
- , Shusuke Kawashima
- & Yosuke Togashi
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Review Article |
Ferroptosis in colorectal cancer: a future target?
- Hong Yan
- , Ronan Talty
- & Caroline H. Johnson
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Loss of alcohol dehydrogenase 1B in cancer-associated fibroblasts: contribution to the increase of tumor-promoting IL-6 in colon cancer
- Romain Villéger
- , Marina Chulkina
- & Irina V. Pinchuk
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| Open AccessThe Glasgow Microenvironment Score and risk and site of recurrence in TNM I–III colorectal cancer
- P. G. Alexander
- , H. C. van Wyk
- & J. H. Park
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Review Article |
A comprehensive systematic review of colorectal cancer screening clinical practices guidelines and consensus statements
- Marta Maes-Carballo
- , Manuel García-García
- & Aurora Bueno-Cavanillas
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Review Article |
Lynch syndrome, molecular mechanisms and variant classification
- Amanda B. Abildgaard
- , Sofie V. Nielsen
- & Rasmus Hartmann-Petersen
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Investigation of the gut microbiome, bile acid composition and host immunoinflammatory response in a model of azoxymethane-induced colon cancer at discrete timepoints
- J. M. Keane
- , C. J. Walsh
- & N. P. Hyland