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Cellular and Molecular Biology

Ferroptosis in colorectal cancer: a future target?

British Journal of Cancer volume 128, pages 1439–1451 (2023)Cite this article

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Abstract

Colorectal cancer (CRC) is the third leading cause of cancer deaths worldwide and is characterised by frequently mutated genes, such as APC, TP53, KRAS and BRAF. The current treatment options of chemotherapy, radiation therapy and surgery are met with challenges such as cancer recurrence, drug resistance, and overt toxicity. CRC therapies exert their efficacy against cancer cells by activating biological pathways that contribute to various forms of regulated cell death (RCD). In 2012, ferroptosis was discovered as an iron-dependent and lipid peroxide-driven form of RCD. Recent studies suggest that therapies which target ferroptosis are promising treatment strategies for CRC. However, a greater understanding of the mechanisms of ferroptosis initiation, propagation, and resistance in CRC is needed. This review provides an overview of recent research in ferroptosis and its potential role as a therapeutic target in CRC. We also propose future research directions that could help to enhance our understanding of ferroptosis in CRC.

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Fig. 1: The regulation and targeting of ferroptosis in CRC.
Fig. 2: Modulation of ferroptosis cancer cell immunity.

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No data was used for the research described in the article.

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Funding

This work was supported by funding from the American Cancer Society Research Scholar Grant 134273-RSG-20-065-01-TBE (CHJ), NIH/NCI under Award Number K12CA215110, and the NIH/NCI Yale SPORE in Skin Cancer under award number 5P50CA121974. RT is supported by NIH/NCI F30CA254246, and OA is supported by the Yale Cancer Center T32CA250803.

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Authors and Affiliations

  1. Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, 06510, USA

    Hong Yan, Oladimeji Aladelokun & Caroline H. Johnson

  2. Department of Pathology, Yale School of Medicine, New Haven, CT, USA

    Ronan Talty & Marcus Bosenberg

  3. Department of Dermatology, Yale School of Medicine, New Haven, CT, USA

    Marcus Bosenberg

  4. Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA

    Marcus Bosenberg

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  1. Hong Yan
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Literature review and data collection were performed by HY and CJ. The first draft of the review was written by HY. Figures and tables were generated by HY. RT participated in editing the draft and tables. OA participated in editing the draft. MB participated in editing the draft. CJ contributed to the draft editing and language improvement. All authors approved the final manuscript.

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Yan, H., Talty, R., Aladelokun, O. et al. Ferroptosis in colorectal cancer: a future target?. Br J Cancer 128, 1439–1451 (2023). https://doi.org/10.1038/s41416-023-02149-6

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