Cancer articles within Nature

Featured

  • Nature Index |

    Misdirected funds could be undermining efforts to improve patient outcomes in regions that need it most.

    • Bec Crew

  • Article |

    A CRISPR–Cas9 screen in a tumour mouse model identifies CD300ld as a tumour receptor on polymorphonuclear myeloid-derived suppressor cells and in vivo experiments indicate that it is a promising target for cancer immunotherapy.

    • Chaoxiong Wang
    • , Xichen Zheng
    •  & Min Luo

  • Article
    | Open Access

    Imaging mass cytometry is used to map the multicellular dynamics of immune checkpoint blockade-treated triple-negative breast cancer, finding that key proliferative fractions and cell–cell interactions drive response, and immunotherapy distinctively remodels tumour structure.

    • Xiao Qian Wang
    • , Esther Danenberg
    •  & H. Raza Ali

  • Article
    | Open Access

    Epitope engineering of donor haematopoietic stem/progenitor cells endows haematopoietic lineages with selective resistance to CAR T cells or monoclonal antibodies, without affecting protein function or regulation, enabling the targeting of genes that are essential for leukaemia survival and reducing the risk of tumour immune escape.

    • Gabriele Casirati
    • , Andrea Cosentino
    •  & Pietro Genovese

  • Article |

    A study describes the metabolic adaptations supporting differentiation, survival and function of tissue-resident memory CD8+ T cells and how to leverage them to enhance immunity against pathogens and tumours.

    • Miguel Reina-Campos
    • , Maximilian Heeg
    •  & Ananda W. Goldrath

  • Article
    | Open Access

    Chromosomal instability in cancer is linked to endoplasmic reticulum stress signalling, immune suppression and metastasis, which is mediated by the cGAS–STING pathway, suppression of which can reduce metastasis.

    • Jun Li
    • , Melissa J. Hubisz
    •  & Samuel F. Bakhoum

  • News & Views |

    Understanding the processes that lead to tumour formation in the pancreas might help in efforts to develop therapies. A new bioinformatics tool called Calligraphy analyses cell–cell signalling to provide fresh insights into how tumours arise.

    • Filip Bednar
    •  & Marina Pasca di Magliano

  • Article |

    Interferon-ε is a tumour suppressor expressed in the epithelial cell of origin of ovarian cancer, which it restricts by direct action on tumour cells and especially by activation of anti-tumour immunity.

    • Zoe R. C. Marks
    • , Nicole K. Campbell
    •  & Paul J. Hertzog

  • Article |

    Netrin-1 is upregulated in cancer models that undergo spontaneous epithelial-to-mesenchymal transition, and its targeting blocks the progression of tumour cells to a late mesenchymal state, suggesting possible therapeutic applications.

    • Justine Lengrand
    • , Ievgenia Pastushenko
    •  & Cédric Blanpain

  • Clinical Briefing |

    The protein netrin-1 is involved in embryonic development and is upregulated in various cancers, including endometrial cancer. In mouse models and a first-in-human trial, blocking netrin-1 with a humanized monoclonal antibody, NP137, prevents a cellular change called the epithelial–mesenchymal transition and inhibits tumour growth.

  • Article
    | Open Access

    We describe netrin-1 upregulation in a majority of human endometrial carcinomas and demonstrate that netrin-1 blockade, using the anti-netrin-1 antibody NP137, is effective both in a mouse model and in patients with endometrial carcinomas.

    • Philippe A. Cassier
    • , Raul Navaridas
    •  & Patrick Mehlen

  • News & Views |

    Molecules have been developed that switch a transcription factor from being a repressor of gene expression to an activator — and thereby able to kill cancer cells. The findings offer a fresh strategy for designing anticancer drugs.

    • James D. Phelan
    •  & Louis M. Staudt

  • Article
    | Open Access

    By using phylogenetic analyses of multiple microdissected samples from both cancer and non-cancer lesions, unique evolutionary histories of breast cancers harbouring a common driver alteration are shown, providing new insight into how breast cancer evolves.

    • Tomomi Nishimura
    • , Nobuyuki Kakiuchi
    •  & Seishi Ogawa

  • Article |

    A new class of molecules can recruit downstream transcription factors or endogenous cancer drivers to cell death promoters and activate the expression of these genes.

    • Sai Gourisankar
    • , Andrey Krokhotin
    •  & Gerald R. Crabtree

  • Research Briefing |

    How the protein p53 suppresses lung cancer, the most common cause of cancer deaths worldwide, has remained unclear. It has been found that p53 impedes the development of lung cancer by promoting a highly specific cell-differentiation program that is characteristic of normal tissue regeneration after an injury.

  • Perspective |

    This Perspective reviews advances in the understanding of the intersection between the DNA damage response and the response to immune checkpoint blockade therapy, and discusses how developments in the field could lead to improved anti-cancer therapies.

    • Anand V. R. Kornepati
    • , Cody M. Rogers
    •  & Tyler J. Curiel

  • Article |

    A study identifies the AT1 cell as a cell of origin for lung adenocarcinoma, and demonstrates that expression of oncogenic KRAS in differentiated AT1 cells reprograms them back into AT2 stem cells that generate indolent lepidic tumours.

    • Nicholas H. Juul
    • , Jung-Ki Yoon
    •  & Tushar J. Desai

  • Article |

    Anti-cancer treatment often results in a subset of the clonal cell population developing resistance to therapy, with resistant cells displaying a diversity of fate types resulting from the intrinsic variability among the clonal population before treatment.

    • Yogesh Goyal
    • , Gianna T. Busch
    •  & Arjun Raj

  • Perspective |

    This Perspective reviews the utility and interpretation of circulating tumour DNA for the detection of residual and recurrent cancers and provides recommendations regarding its clinical application for a variety of solid tumours.

    • Stacey A. Cohen
    • , Minetta C. Liu
    •  & Alexey Aleshin

  • Article |

    Induction of APOBEC3A in response to targeted therapies drives evolution of drug-tolerant persister cells, suggesting that its suppression may represent a potential therapeutic strategy in the prevention of acquired resistance to lung cancer targeted therapy.

    • Hideko Isozaki
    • , Ramin Sakhtemani
    •  & Aaron N. Hata

  • News & Views |

    It turns out that commitment to cell division is not an irreversible switch. In the absence of sustained stimulation by growth factor proteins during DNA replication, cells can quit the cell cycle before cell division occurs.

    • Alexis R. Barr

  • Article |

    A study reports the development of an algorithm, BISCUT, that detects genomic loci under selective pressure by relying on the distribution of breakpoints across chromosome arms, and uses it to explore how aneuploidies affect tumorigenesis.

    • Juliann Shih
    • , Shahab Sarmashghi
    •  & Rameen Beroukhim

  • Article |

    Callosal projection neurons located in the hemisphere contralateral to primary glioblastoma promote progression and widespread infiltration, and screening of axon guidance genes identified SEMA4F as a key regulator of tumourigenesis and activity-dependent progression.

    • Emmet Huang-Hobbs
    • , Yi-Ting Cheng
    •  & Benjamin Deneen

  • Article |

    A murine colorectal cancer (CRC) model shows that mutant KRAS-STAT4-mediated upregulation of Y chromosome KDM5D contributes to the sex differences in KRAS-mutant CRC, providing an actionable therapeutic strategy for metastasis risk reduction for men afflicted with KRAS-mutant CRC.

    • Jiexi Li
    • , Zhengdao Lan
    •  & Ronald A. DePinho

  • Research Briefing |

    The function of immune cells called B cells in cancer has been controversial. Single-cell profiling has identified a previously undescribed subset of B cells that express a protein called TIM-1 and that multiply in response to melanoma tumour growth. Deletion of the gene that encodes TIM-1 in these cells unleashed an antitumour immune response.

  • Article |

    Loss of the Y chromosome in tumour cells is associated with a poor prognosis for patients with bladder cancer by causing local T cell exhaustion, which also increases the response to immune checkpoint blockade therapy.

    • Hany A. Abdel-Hafiz
    • , Johanna M. Schafer
    •  & Dan Theodorescu

  • News & Views |

    Two studies now shed light on how chromosomes that undergo catastrophic shattering are transmitted to daughter cells during cell division, thereby enabling them to be reassembled for the benefit of cancer cells.

    • Yibo Xue
    •  & Daniel Durocher

  • Review Article |

    This Review examines the interplay between the nervous system and tumours, from cancer initiation to progression and metastasis.

    • Rebecca Mancusi
    •  & Michelle Monje

  • Article |

    Chromothriptically produced pieces of a micronucleated chromosome are shown to be tethered together in mitosis by a protein complex consisting of MDC1, TOPBP1 and CIP2A, thus enabling their inheritance by a single daughter cell.

    • Prasad Trivedi
    • , Christopher D. Steele
    •  & Don W. Cleveland

  • Article
    | Open Access

    This article describes a mechanism through which CD4+ T cells can eradicate MHC-deficient tumours that escape direct CD8+ T cell targeting and thereby complement the activity of CD8+ T cells and natural killer cells to advance cancer immunotherapies.

    • Bastian Kruse
    • , Anthony C. Buzzai
    •  & Thomas Tüting

  • News & Views |

    Much remains to be discovered about how premalignant cells become cancer cells. An analysis of the development of a type of human leukaemia implicates ultraviolet light in triggering a rare form of cancer.

    • Elli Papaemmanuil

  • Article
    | Open Access

    Micronuclei, which are common features of nuclei in cancer cells, can generate heritable sources of transcriptional suppression, a finding that establishes an inherent relationship between chromosomal instability and variation in chromatin state and gene expression.

    • Stamatis Papathanasiou
    • , Nikos A. Mynhier
    •  & David Pellman

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