Featured
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Matters Arising |
In vivo quantification of mitochondrial membrane potential
- Nathaniel M. Alpert
- , Matthieu Pelletier-Galarneau
- & Georges El Fakhri
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Article |
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer
A positron emission tomography imaging tracer is developed to image mitochondrial function in vivo, and application of this tracer to a mouse model of lung cancer identifies distinct functional mitochondrial heterogeneity between tumour cells.
- Milica Momcilovic
- , Anthony Jones
- & David B. Shackelford
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Article |
Glutamatergic synaptic input to glioma cells drives brain tumour progression
Neurons form glutamatergic synapses with glioma cells in mice and humans, and inhibition of AMPA receptors reduces glioma cell invasion and growth.
- Varun Venkataramani
- , Dimitar Ivanov Tanev
- & Thomas Kuner
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Letter |
T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments
Here, leukaemia cells are followed by intravital microscopy as they infiltrate mouse bone marrow and respond to chemotherapy, revealing that at all stages analysed they are highly motile and do not display any associations with particular bone marrow sub-compartments.
- Edwin D. Hawkins
- , Delfim Duarte
- & Cristina Lo Celso
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Letter |
Visualization of immediate immune responses to pioneer metastatic cells in the lung
Tracing the fate of circulating tumour cells by intravital two-photon lung imaging shows that tumours produce microparticles as they arrive and these migrate along the lung vasculature and are mostly taken up by interstitial myeloid cells, in a process that contributes to metastatic seeding; a minor subset of microparticles is engulfed by conventional dendritic cells, which are thought to contribute to the initiation of an anti-tumour immune response in lung-draining lymph nodes.
- Mark B. Headley
- , Adriaan Bins
- & Matthew F. Krummel
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Article |
Brain tumour cells interconnect to a functional and resistant network
Brain tumours are difficult to treat because of their propensity to infiltrate brain tissue; here long processes, or tumour microtubes, extended by astrocytomas are shown to promote brain infiltration and to create an interconnected network that enables multicellular communication and that protects the tumours from radiotherapy-induced cell death, suggesting that disruption of the network could be a new therapeutic approach.
- Matthias Osswald
- , Erik Jung
- & Frank Winkler
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Outlook |
Medical imaging: Removing the blindfold
Using a variety of creative imaging techniques, researchers are tracking the dynamic interactions of immune and cancer cells. Their results will guide drug development.
- Katherine Bourzac
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Outlook |
Next-generation scans: Seeing into the future
From magnetically tagged sugar to smoke-sensing surgical knives and beams of high-energy protons, the next wave of imaging technologies will provide a clearer view of the body.
- Peter Gwynne
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Outlook |
Software: The computer will see you now
From image-analysis software to lens-free microscopes that fit on a mobile phone, new tools are providing pathologists with clearer and more informative images.
- Katherine Bourzac
Cell–matrix interface regulates dormancy in human colon cancer stem cells