Bone cancer articles within Nature

Featured

• Article | 24 May 2023

  Tumour extracellular vesicles and particles induce liver metabolic dysfunction

  Remote tumours cause liver dysfunction by releasing extracellular vesicles and particles containing palmitic acid, which induces TNF signalling in Kupffer cells, resulting in inflammation, fatty deposits and metabolic dysregulation, thus both reducing the efficacy and increasing the toxicity of chemotherapies.

  • Gang Wang
  • , Jianlong Li
  •  & David Lyden

• Article | 19 October 2016

  Break-induced telomere synthesis underlies alternative telomere maintenance

  Alternative lengthening of telomeres in cancer cells is initiated by a specialized replisome and noncanonical homologous recombination at damaged telomeres, culminating in the synthesis of long tracts of telomere DNA.

  • Robert L. Dilley
  • , Priyanka Verma
  •  & Roger A. Greenberg