Focus on RNA
In This Issue - pv
doi:10.1038/nchembio0107-v
Focus
Focus on RNA
- Focus issue:
- January 2007 Volume 3, No 1
RNA has occupied a pivotal position in the 'central dogma' of molecular biology, which states that information flows from DNA through RNA to proteins. In this issue, we feature a collection of articles that discuss the diverse functional roles of RNA in biological systems and highlight recent discoveries in RNA chemical biology, including advances in transcription, RNA structural biology, RNA interference and RNA engineering.
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Editorial
Focus on RNA
A windfall for RNA - p1
doi:10.1038/nchembio0107-1
Two 2006 Nobel prizes reflect the central role of RNA in gene regulation and emphasize the interplay of discoveries in chemistry and biology.
Full Text - A windfall for RNA | PDF (702 KB) - A windfall for RNA
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Commentaries
Focus on RNA
Chemical crosshairs on the central dogma - pp2 - 7
Aseem Z Ansari
doi:10.1038/nchembio0107-2
As cellular machines and processes that regulate the flow of genomic information have come into sharper focus, a new level of chemical control has become possible. The scope of such chemical intervention extends from the mechanistic dissection of biochemical processes in living cells to the targeted control of gene networks and cell fate.
Full Text - Chemical crosshairs on the central dogma | PDF (1,616 KB) - Chemical crosshairs on the central dogma
Focus on RNA
RNA learns from antisense - pp8 - 11
David R Corey
doi:10.1038/nchembio0107-8
RNA interference provides powerful tools for controlling gene expression in cultured cells. Whether RNAi will provide similarly powerful drugs is unknown. Lessons from development of antisense oligonucleotide drugs may provide some clues.
Full Text - RNA learns from antisense | PDF (988 KB) - RNA learns from antisense
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Elements
Focus on RNA
RNA at Santa Cruz - p13
Mirella Bucci
doi:10.1038/nchembio0107-13
Nestled in an atmosphere that resembles a national park, the Center for Molecular Biology of RNA at the University of California, Santa Cruz is fulfilling Harry Noller's vision of bringing together multidisciplinary researchers to solve problems that range from finding obscure RNAs to understanding the origin of life.
Full Text - RNA at Santa Cruz | PDF (571 KB) - RNA at Santa Cruz
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Perspectives
Focus on RNA
Synthetic RNA circuits - pp23 - 28
Eric A Davidson & Andrew D Ellington
doi:10.1038/nchembio846
Abstract - Synthetic RNA circuits | Full Text - Synthetic RNA circuits | PDF (239 KB) - Synthetic RNA circuits
Focus on RNA
Natural expansion of the genetic code - pp29 - 35
Alexandre Ambrogelly, Sotiria Palioura & Dieter Söll
doi:10.1038/nchembio847
Abstract - Natural expansion of the genetic code | Full Text - Natural expansion of the genetic code | PDF (466 KB) - Natural expansion of the genetic code
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Focus on RNA
Slicer and the Argonautes - pp36 - 43
Niraj H Tolia & Leemor Joshua-Tor
doi:10.1038/nchembio848
Abstract - Slicer and the Argonautes | Full Text - Slicer and the Argonautes | PDF (1,403 KB) - Slicer and the Argonautes
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