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Chemical crosshairs on the central dogma

Nature Chemical Biology volume 3, pages 2–7 (2007)Cite this article

As cellular machines and processes that regulate the flow of genomic information have come into sharper focus, a new level of chemical control has become possible. The scope of such chemical intervention extends from the mechanistic dissection of biochemical processes in living cells to the targeted control of gene networks and cell fate.

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Figure 1: The view of RNA polymerase II since its discovery in 1969.
Figure 2: α-Amanitin binding site in the yeast RNA polymerase II.
Figure 3: Biological concepts that have influenced the design of chemical ligands.
Figure 4: Chemical control of the central dogma.

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Acknowledgements

I apologize to many friends and colleagues whom I could not reference, and I thank those who generously helped in assembling this commentary. The support of the US National Institutes of Health and the Shaw and Keck foundations is gratefully acknowledged.

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  1. the Genome Center of Wisconsin and the Department of Biochemistry, 433 Babcock Drive, University of Wisconsin-Madison, Madison, 53706, Wisconsin, USA

    Aseem Z Ansari

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Ansari, A. Chemical crosshairs on the central dogma. Nat Chem Biol 3, 2–7 (2007). https://doi.org/10.1038/nchembio0107-2

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