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Commentary

Nature Chemical Biology 3, 8–11 (1 January 2007) | doi:10.1038/nchembio0107-8

RNA learns from antisense

David R Corey

Few discoveries have had the immediate and widespread impact of RNA interference (RNAi). The demonstration that short synthetic RNAs can inhibit gene expression in cultured mammalian cells unleashed a tidal wave of experimentation that has affected virtually every field of biological science.