Nature Chemical Biology - CURRENT ISSUE : August 2008 - Vol 4 No 8
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Rafting the Akt rapids
Article by LasserreLipid rafts are thought to be important in cell membrane organization and function, but the role and composition of these domains is not clear. A new study shows that rafts affect signaling pathways, and that proteins may play an active role in raft formation.
FOCUS
Focus on cooperativity
EditorialNew mechanistic insights are extending our understanding of cooperativity in biochemical processes. In this issue, we feature a collection of articles highlighting current research and future challenges in exploring cooperative systems in chemistry and biology.
CURRENT ISSUE
Integrated chemical genetics
Article by HoonMany approaches to forward chemical genetic screens are available, but alone each has limitations. An integrated cell-based platform that improves the specificity of small-molecule target identification is used to uncover potential protein targets of previously uncharacterized synthetic compounds.
CURRENT ISSUE
Sweetening tau
Article by YuzwaA dynamic equilibrium exists between phosphorylation and O-GlcNAcylation of the microtubule-associated protein tau, which becomes hyperphosphorylated in Alzheimer’s disease. A rationally designed compound inhibits O-GlcNAcase by binding its active site, thereby elevating O-GlcNAc and lowering tau phosphorylation in vivo.
THE FUNCTIONAL GLYCOMICS GATEWAY
The free resource for biochemists interested in glycobiology.
The Functional Glycomics Gateway provides a wealth of glycobiology information. It includes monthly editorial updates about research advances and events, and a rich collection of research data and reference databases about glycans and glycan-binding proteins.
