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Accessing natural vaccine adjuvants
An integrative approach has now enabled elucidation of the complete biosynthetic pathway of a prominent saponin adjuvant. Reconstruction of the whole biosynthetic pathway in a heterologous host provides new perspectives for the biotechnological supply of this immunostimulant.
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Chemical Biology of Microbiomes
Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in this collection of recent articles from Nature Portfolio.
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Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D
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De novo-designed transmembrane proteins bind and regulate a cytokine receptor
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A solid beta-sheet structure is formed at the surface of FUS droplets during aging
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Functional genomic screens with death rate analyses reveal mechanisms of drug action