Review abstract
Nature Chemical Biology 3, 36 - 43 (2007)
Published online: 15 December 2006 | doi:10.1038/nchembio848
Slicer and the Argonautes
Niraj H Tolia1 & Leemor Joshua-Tor1
Abstract
Though they started out as somewhat mysterious components of the RNAi effector complexes, Argonaute proteins have since taken center stage in RNAi gene silencing. They interact with small RNAs to effect gene silencing in all RNAi-related pathways known so far. We will review the dramatic advances in our understanding of the role of the Argonautes in RNAi through studies of their structure and function.
- W.M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.
Correspondence to: Leemor Joshua-Tor1 e-mail: leemor@cshl.edu
