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Latest Reviews

  • Review |

    Fluorescence nanoscopy enables the optical imaging of cellular components with resolutions at the nanometre scale. With the growing availability of super-resolution microscopes, nanoscopy methods are being increasingly applied. Quantitative, multicolour, live-cell nanoscopy and the corresponding labelling strategies are under continuous development.

    • Steffen J. Sahl
    • , Stefan W. Hell
    •  & Stefan Jakobs
  • Review |

    tRNAs exist as diverse species, including sequence isoforms and nuclease-generated fragments, which are further functionally diversified by base modifications and various protein interactions. Perhaps unsurprisingly, tRNAs are now being implicated in various cellular processes beyond protein synthesis per se, including in stress responses, proliferation, cell fate determination and tumorigenesis.

    • Paul Schimmel
  • Review |

    Lipolysis degrades triacylglycerols to supply cells with free fatty acids, which are essential components of membrane lipids and substrates for energy production. Recent discoveries transformed our understanding of the functions of and crosstalk between 'neutral' lipolysis, which occurs in the cytosol, and lipophagy and 'acid' lipolysis, which occur in lysosomes, and how dysfunction in these processes contributes to metabolic diseases.

    • Rudolf Zechner
    • , Frank Madeo
    •  & Dagmar Kratky
  • Review |

    Heat shock transcription factors (HSFs) regulate heat shock proteins in conditions of thermal stress, but they also control gene expression in other stress conditions, as well as in other contexts, including the regulation of cell proliferation and energy metabolism. HSFs are misregulated in various diseases, such as cancer and neurodegeneration, which underlines their important physiological roles.

    • Rocio Gomez-Pastor
    • , Eileen T. Burchfiel
    •  & Dennis J. Thiele
  • Review |

    Assembly of the microtubule nucleus is energetically unfavourable and, in vivo, microtubule nucleation requires support, such as a stable template, to stabilize the initial weak interactions between tubulin dimers. Microtubules can also be nucleated in the absence of a template by certain microtubule-associated proteins, which stabilize the nascent nucleation intermediates.

    • Johanna Roostalu
    •  & Thomas Surrey
  • Review |

    Replication stress is controlled by the kinase ataxia telangiectasia and Rad3-related (ATR), which senses and resolves threats to DNA integrity. ATR activation is complex and involves a core set of components that recruit ATR to stressed replication forks, stimulate its kinase activity and amplify downstream signalling to maintain the stability of replication forks.

    • Joshua C. Saldivar
    • , David Cortez
    •  & Karlene A. Cimprich

News & Comment

  • Journal Club |

    Daniel Gerlich discusses how a study by the Hyman laboratory introduced the theory of liquid phase separation to cell biology and its implications for the understanding of cell organization and function.

    • Daniel W. Gerlich
  • Research Highlight |

    A new imaging technique (ChromEMT) enables the visualization of the local polymer structure and global 3D organization of chromatin in the nucleus of intact interphase and mitotic human cells.

    • Kim Baumann
  • Research Highlight |

    The skin is able to counteract tissue aberrancies resulting from tissue overgrowth and to restore normal tissue architecture by eliminating aberrant cells.

    • Paulina Strzyz

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