Featured
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Gastrointestinal infections and gastrointestinal haemorrhage are underestimated but serious adverse events in chimeric antigen receptor T-cell recipients: A real-world study
- Zhiqiang Song
- , Yang Wang
- & Jianmin Yang
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The integrate profiling of single-cell and spatial transcriptome RNA-seq reveals tumor heterogeneity, therapeutic targets, and prognostic subtypes in ccRCC
- Yanlong Zhang
- , Xuefeng Huang
- & Xi Wang
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Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy
- Haruki Horiguchi
- , Tsuyoshi Kadomatsu
- & Yuichi Oike
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Single-cell atlas reveals the immunosuppressive microenvironment and Treg cells landscapes in recurrent Glioblastoma
- Xingdong Wang
- , Yizhi Ge
- & Hengzhu Zhang
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| Open AccessAn alternative fully human anti-BCMA CAR-T shows response for relapsed or refractory multiple myeloma with anti-BCMA CAR-T exposures previously
- Qingming Wang
- , Runhong Wei
- & Zhi Cheng
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Enhancing CAR-T cells: unleashing lasting impact potential with phytohemagglutinin activation in in vivo leukemia model
- Berranur Sert
- , Gamze Gulden
- & Cihan Tastan
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| Open AccessSiglec-15 on macrophages suppress the immune microenvironment in patients with PD-L1 negative non-metastasis lung adenocarcinoma
- Ziqi Huang
- , Yan Guo
- & Lili Yang
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SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma
- Jiashun Wu
- , Yi Shen
- & Guiqing Liao
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IGH repertoire analysis at scale: deciphering the complexity of B cell infiltration and migration in esophageal squamous cell carcinoma
- Longlong Wang
- , Yong Zhou
- & Weimin Zhang
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Article
| Open AccessAntibody-mediated delivery of viral epitopes to redirect EBV-specific CD8+ T-cell immunity towards cancer cells
- Willemijn van der Wulp
- , Dennis F. G. Remst
- & Mirjam H. M. Heemskerk
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Review Article |
Small extracellular vesicle TGF-β in cancer progression and immune evasion
- Reza Hosseini
- , Nashmin Hosseinzadeh
- & Mohammad Esmaeil Akbari
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Inducible TgfbR1 and Pten deletion in a model of tongue carcinogenesis and chemoprevention
- Felipe F. Lamenza
- , Nathan M. Ryan
- & Steve Oghumu
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Review Article
| Open AccessTherapeutic utility of engineered myeloid cells in the tumor microenvironment
- Alessandro Canella
- & Prajwal Rajappa
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Article
| Open AccessGlioblastoma glycolytic signature predicts unfavorable prognosis, immunological heterogeneity, and ENO1 promotes microglia M2 polarization and cancer cell malignancy
- Xisong Liang
- , Zeyu Wang
- & Mingyu Zhang
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Rational pemetrexed combined with CIK therapy plus anti-PD-1 mAbs administration sequence will effectively promote the efficacy of CIK therapy in non-small cell lung cancer
- Shaochuan Liu
- , Yuan Meng
- & Qian Sun
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CCR3 blockage elicits polyploidization associated with the signatures of epithelial-mesenchymal transition in carcinoma cell lines
- Yuichiro Kaibori
- & Daisuke Nagakubo
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High CAR intensity of expression confers enhanced antitumor effect against lymphoma without functional exhaustion
- Ana Carolina Caballero
- , Laura Escribà-Garcia
- & Javier Briones
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Article
| Open AccessCDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages
- Jia-Bin Wang
- , You-Xin Gao
- & Chang-Ming Huang
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The cross-talk of cancer-associated fibroblasts assist in prognosis and immunotherapy in patients with breast carcinoma
- Xuyu Gu
- , Shiya Zheng
- & Qin Zhou
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Lipid-related FABP5 activation of tumor-associated monocytes fosters immune privilege via PD-L1 expression on Treg cells in hepatocellular carcinoma
- Jin Liu
- , Binwen Sun
- & Liming Wang
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Article
| Open AccessLoss-of-function of the hippo transducer TAZ reduces mammary tumor growth through a myeloid-derived suppressor cell-dependent mechanism
- He Shen
- , Yuwen Zhang
- & Jianmin Zhang
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Review Article
| Open AccessApplication of ATAC-seq in tumor-specific T cell exhaustion
- Chufeng Chen
- , Jiaying Liu
- & Peng Luo
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Article
| Open AccessRegional infusion of a class C TLR9 agonist enhances liver tumor microenvironment reprogramming and MDSC reduction to improve responsiveness to systemic checkpoint inhibition
- Chandra C. Ghosh
- , Kara R. Heatherton
- & Steven C. Katz
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Activation of CEACAM1 with an agonistic monoclonal antibody results in inhibition of melanoma cells
- Ilan Zaffran
- , Nadine Landolina
- & Francesca Levi-Schaffer
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Article
| Open AccessDescription and optimization of a multiplex bead-based flow cytometry method (MBFCM) to characterize extracellular vesicles in serum samples from patients with hematological malignancies
- Lin Li
- , André Görgens
- & Helga Schmetzer
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Review Article
| Open AccessNext generation self-replicating RNA vectors for vaccines and immunotherapies
- Parinaz Aliahmad
- , Shigeki J. Miyake-Stoner
- & Nathaniel S. Wang
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Article |
Identification of an immune gene-associated prognostic signature in patients with bladder cancer
- Zhiqiang Wang
- , Liping Zhu
- & Ling Peng
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Intratumoral DNA-based delivery of checkpoint-inhibiting antibodies and interleukin 12 triggers T cell infiltration and anti-tumor response
- Liesl Jacobs
- , Lidia Yshii
- & Paul Declerck
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Homeostatic cytokines tune naivety and stemness of cord blood-derived transgenic T cells
- Chrystel Marton
- , Patricia Mercier-Letondal
- & Yann Godet
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CXCR4 and anti-BCMA CAR co-modified natural killer cells suppress multiple myeloma progression in a xenograft mouse model
- Yu Yang Ng
- , Zhicheng Du
- & Shu Wang
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Review Article |
Cutting both ways: the innate immune response to oncolytic virotherapy
- David Mealiea
- & J. Andrea McCart
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Article
| Open AccessTumor suppressor immune gene therapy to reverse immunotherapy resistance
- Sunil Chada
- , Dora Wiederhold
- & Robert E. Sobol
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Enhanced antitumor immune response in melanoma tumor model by anti-PD-1 small interference RNA encapsulated in nanoliposomes
- Mehdi Barati
- , Farshad Mirzavi
- & Mahmoud Reza Jaafari
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Correspondence |
Protean role of epigenetic mechanisms and their impact in regulating the Tregs in TME
- A. S. Smiline Girija
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Article
| Open AccessCytokine-enhanced cytolytic activity of exosomes from NK Cells
- Yutaka Enomoto
- , Peng Li
- & Warren J. Leonard
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Review Article |
Combination therapy with CAR T cells and oncolytic viruses: a new era in cancer immunotherapy
- Ramazan Rezaei
- , Hadi Esmaeili Gouvarchin Ghaleh
- & Akbar Ghorbani Alvanegh
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Suppression of tumor growth and metastasis in Shkbp1 knockout mice
- Qing Liu
- , Haobin Li
- & Jiangchao Li
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CF33-hNIS-antiPDL1 virus primes pancreatic ductal adenocarcinoma for enhanced anti-PD-L1 therapy
- Zhifang Zhang
- , Annie Yang
- & Yanghee Woo
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Review Article |
Cancer immunotherapies revisited: state of the art of conventional treatments and next-generation nanomedicines
Schematic summary of the main currently existing immunotherapies; from therapeutic antibodies to newly developed nanomedicines.
- Coral García-Fernández
- , Anna Saz
- & Salvador Borrós
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Proof of principle study of sequential combination atezolizumab and Vigil in relapsed ovarian cancer
- Rodney P. Rocconi
- , Erin E. Stevens
- & John Nemunaitis
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Review Article |
Cancer-associated fibroblasts: overview, progress, challenges, and directions
- Qinrong Ping
- , Ruping Yan
- & Ruhong Li
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Review Article
| Open AccessTCR-like CARs and TCR-CARs targeting neoepitopes: an emerging potential
- Mansour Poorebrahim
- , Niloufar Mohammadkhani
- & Angel Cid-Arregui
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Article |
DNA-double strand breaks enhance the expression of major histocompatibility complex class II through the ATM-NF-κΒ-IRF1-CIITA pathway
- Tsukasa Oda
- , Ruri Nakamura
- & Takayuki Yamashita
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Review Article
| Open AccessKey chemokines direct migration of immune cells in solid tumors
- Karan Kohli
- , Venu G. Pillarisetty
- & Teresa S. Kim
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Review Article |
Nanomedicine-based cancer immunotherapy: recent trends and future perspectives
- Vinoth-Kumar Lakshmanan
- , Shlok Jindal
- & Salem Chouaib
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Review Article |
Recent updates on chimeric antigen receptor T cell therapy for hepatocellular carcinoma
- Jiaojiao Guo
- & Qi Tang
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Article
| Open AccessTherapeutic anti-glioma effect of the combined action of PCSK inhibitor with the anti-tumoral factors secreted by Poly (I:C)-stimulated macrophages
- Mélanie Rose
- , Marie Duhamel
- & Michel Salzet
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Review Article
| Open AccessViroimmunotherapy for breast cancer: promises, problems and future directions
- Shyambabu Chaurasiya
- & Yuman Fong
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Review Article |
The future of microfluidics in immune checkpoint blockade
- Jonathan Briones
- , Wilfred Espulgar
- & Masato Saito
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