Featured
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Review Article |
CRISPR-Cas gene knockouts to optimize engineered T cells for cancer immunotherapy
- Valentine De Castro
- , Jeanne Galaine
- & Yann Godet
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Article
| Open Access
RevCAR-expressing immune effector cells for targeting of Fn14-positive glioblastoma
- Haidy A. Saleh
- , Nicola Mitwasi
- & Anja Feldmann
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Review Article
| Open Access
PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment
- Jie Gao
- , Anying Xiong
- & Xiang He
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Article |
The integrate profiling of single-cell and spatial transcriptome RNA-seq reveals tumor heterogeneity, therapeutic targets, and prognostic subtypes in ccRCC
- Yanlong Zhang
- , Xuefeng Huang
- & Xi Wang
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Article |
Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy
- Haruki Horiguchi
- , Tsuyoshi Kadomatsu
- & Yuichi Oike
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Article |
GRIN2A mutation is a novel indicator of stratifying beneficiaries of immune checkpoint inhibitors in multiple cancers
- Gan-xun Li
- , Rui-zhi Chang
- & Ze-yang Ding
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Article
| Open Access
An alternative fully human anti-BCMA CAR-T shows response for relapsed or refractory multiple myeloma with anti-BCMA CAR-T exposures previously
- Qingming Wang
- , Runhong Wei
- & Zhi Cheng
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Article
| Open Access
Siglec-15 on macrophages suppress the immune microenvironment in patients with PD-L1 negative non-metastasis lung adenocarcinoma
- Ziqi Huang
- , Yan Guo
- & Lili Yang
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Article |
Downstream STING pathways IRF3 and NF-κB differentially regulate CCL22 in response to cytosolic dsDNA
- Jihyun Kim
- , Jocelyn V. Pena
- & Pamela R. Cook
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Article |
IGH repertoire analysis at scale: deciphering the complexity of B cell infiltration and migration in esophageal squamous cell carcinoma
- Longlong Wang
- , Yong Zhou
- & Weimin Zhang
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Article
| Open Access
Antibody-mediated delivery of viral epitopes to redirect EBV-specific CD8+ T-cell immunity towards cancer cells
- Willemijn van der Wulp
- , Dennis F. G. Remst
- & Mirjam H. M. Heemskerk
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Review Article |
Small extracellular vesicle TGF-β in cancer progression and immune evasion
- Reza Hosseini
- , Nashmin Hosseinzadeh
- & Mohammad Esmaeil Akbari
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Article |
Inducible TgfbR1 and Pten deletion in a model of tongue carcinogenesis and chemoprevention
- Felipe F. Lamenza
- , Nathan M. Ryan
- & Steve Oghumu
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Review Article
| Open Access
Therapeutic utility of engineered myeloid cells in the tumor microenvironment
- Alessandro Canella
- & Prajwal Rajappa
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Article
| Open Access
β3-adrenergic receptor on tumor-infiltrating lymphocytes sustains IFN-γ-dependent PD-L1 expression and impairs anti-tumor immunity in neuroblastoma
- Gennaro Bruno
- , Nicoletta Nastasi
- & Maura Calvani
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Article
| Open Access
Glioblastoma glycolytic signature predicts unfavorable prognosis, immunological heterogeneity, and ENO1 promotes microglia M2 polarization and cancer cell malignancy
- Xisong Liang
- , Zeyu Wang
- & Mingyu Zhang
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Article
| Open Access
PDPN contributes to constructing immunosuppressive microenvironment in IDH wildtype glioma
- Xuya Wang
- , Xisen Wang
- & Xuejun Yang
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Article
| Open Access
CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages
- Jia-Bin Wang
- , You-Xin Gao
- & Chang-Ming Huang
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Article |
The cross-talk of cancer-associated fibroblasts assist in prognosis and immunotherapy in patients with breast carcinoma
- Xuyu Gu
- , Shiya Zheng
- & Qin Zhou
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Article
| Open Access
Targeting the androgen receptor to enhance NK cell killing efficacy in bladder cancer by modulating ADAR2/circ_0001005/PD-L1 signaling
- Qing Liu
- , Bosen You
- & Wanhai Xu
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Article |
Lipid-related FABP5 activation of tumor-associated monocytes fosters immune privilege via PD-L1 expression on Treg cells in hepatocellular carcinoma
- Jin Liu
- , Binwen Sun
- & Liming Wang
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Article
| Open Access
Loss-of-function of the hippo transducer TAZ reduces mammary tumor growth through a myeloid-derived suppressor cell-dependent mechanism
- He Shen
- , Yuwen Zhang
- & Jianmin Zhang
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Review Article |
Cancer vaccine strategies using self-replicating RNA viral platforms
- Gabrielle P. Dailey
- , Erika J. Crosby
- & Zachary C. Hartman
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Article
| Open Access
Regional infusion of a class C TLR9 agonist enhances liver tumor microenvironment reprogramming and MDSC reduction to improve responsiveness to systemic checkpoint inhibition
- Chandra C. Ghosh
- , Kara R. Heatherton
- & Steven C. Katz
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Review Article |
Review of bi-specific therapies in uveal melanoma
- Marlana Orloff
- , Rino Seedor
- & Takami Sato
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Article |
Identification of an immune gene-associated prognostic signature in patients with bladder cancer
- Zhiqiang Wang
- , Liping Zhu
- & Ling Peng
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Article
| Open Access
Tumor suppressor immune gene therapy to reverse immunotherapy resistance
- Sunil Chada
- , Dora Wiederhold
- & Robert E. Sobol
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Article |
Enhanced antitumor immune response in melanoma tumor model by anti-PD-1 small interference RNA encapsulated in nanoliposomes
- Mehdi Barati
- , Farshad Mirzavi
- & Mahmoud Reza Jaafari
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Correspondence |
Protean role of epigenetic mechanisms and their impact in regulating the Tregs in TME
- A. S. Smiline Girija
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Article
| Open Access
Inhibition of host Ogr1 enhances effector CD8+ T-cell function by modulating acidic microenvironment
- Lin Cao
- , Weisha Li
- & Ran Gao
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Article |
Suppression of tumor growth and metastasis in Shkbp1 knockout mice
- Qing Liu
- , Haobin Li
- & Jiangchao Li
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Review Article |
Cancer-associated fibroblasts: overview, progress, challenges, and directions
- Qinrong Ping
- , Ruping Yan
- & Ruhong Li
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Review Article |
Recent advances in immune therapies for gastric cancer
- Matthew J. Olnes
- & Holly A. Martinson
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Article |
DNA-double strand breaks enhance the expression of major histocompatibility complex class II through the ATM-NF-κΒ-IRF1-CIITA pathway
- Tsukasa Oda
- , Ruri Nakamura
- & Takayuki Yamashita
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Review Article
| Open Access
Key chemokines direct migration of immune cells in solid tumors
- Karan Kohli
- , Venu G. Pillarisetty
- & Teresa S. Kim
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Review Article |
The future of microfluidics in immune checkpoint blockade
- Jonathan Briones
- , Wilfred Espulgar
- & Masato Saito
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Article
| Open Access
Expression pattern of m6A regulators is significantly correlated with malignancy and antitumor immune response of breast cancer
- Xiaofang He
- , Liqiang Tan
- & Guoping Shen
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Article |
Modeling oncolytic virus dynamics in the tumor microenvironment using zebrafish
- David Mealiea
- , Emilie Boudreau
- & J. Andrea McCart
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Article |
Apatinib prevents natural killer cell dysfunction to enhance the efficacy of anti-PD-1 immunotherapy in hepatocellular carcinoma
- Yinli Yang
- , Cong Wang
- & Zhanyu Pan
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Review Article
| Open Access
Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms
- Rong En Tay
- , Emma K. Richardson
- & Han Chong Toh
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Review Article |
TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials
- Khalil Choucair
- , Susan Morand
- & John Nemunaitis
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Article |
CLEC5A expressed on myeloid cells as a M2 biomarker relates to immunosuppression and decreased survival in patients with glioma
- Luqing Tong
- , Jiabo Li
- & Xuejun Yang
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Article |
Phase I neoadjuvant study of intravesical recombinant fowlpox-GM-CSF (rF-GM-CSF) or fowlpox-TRICOM (rF-TRICOM) in patients with bladder carcinoma
- Daniella E. Portal
- , Robert E. Weiss
- & Edmund C. Lattime
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Brief Communication |
Enhanced antitumor efficacy of an oncolytic adenovirus armed with an EGFR-targeted BiTE using menstrual blood-derived mesenchymal stem cells as carriers
- Paula Barlabé
- , Jana de Sostoa
- & Rafael Moreno
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Article |
Intratumoral expression using a NFkB-based promoter enhances IL12 antitumor efficacy
- Guillermo Garaulet
- , Gema Pérez-Chacon
- & Antonio Rodríguez
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Article |
Intratumoral IFN-α gene delivery reduces tumor-infiltrating regulatory T cells through the downregulation of tumor CCL17 expression
- Aya Hirata
- , Hisayoshi Hashimoto
- & Kazunori Aoki
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Article |
Antitumor effect of antibiotic resistance gene-free plasmids encoding interleukin-12 in canine melanoma model
- Ursa Lampreht Tratar
- , Spela Kos
- & Maja Cemazar
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Review |
Gene-expression profiling to predict responsiveness to immunotherapy
- N B Jamieson
- & A V Maker
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Review |
Chimeric antigen receptors for treatment of glioblastoma: a practical review of challenges and ways to overcome them
- S Sengupta
- , G Mao
- & P Sampath
Phosphoglycerate mutase 1 promotes breast cancer progression through inducing immunosuppressive M2 macrophages