Health sciences

Definition

The health sciences study all aspects of health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.

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Latest Research and Reviews

  • Protocols |

    The levels of monoamines and their cofactors in cerebrospinal fluid are strong indicators for dopamine and serotonin biosynthesis and turnover. This protocol describes a set of HPLC-based approaches for the quantitative detection of these molecules.

    • Marta Batllori
    • , Marta Molero-Luis
    • , Aida Ormazabal
    • , Mercedes Casado
    • , Cristina Sierra
    • , Angels García-Cazorla
    • , Manju Kurian
    • , Simon Pope
    • , Simon J Heales
    •  & Rafael Artuch
    Nature Protocols 12, 2359–2375
  • Research |

    After acute inflammation, epithelial stem cells retain a memory that accelerates restoration of the skin barrier during subsequent tissue damage, and this enhancement is dependent on the AIM2 inflammasome and its downstream effectors.

    • Shruti Naik
    • , Samantha B. Larsen
    • , Nicholas C. Gomez
    • , Kirill Alaverdyan
    • , Ataman Sendoel
    • , Shaopeng Yuan
    • , Lisa Polak
    • , Anita Kulukian
    • , Sophia Chai
    •  & Elaine Fuchs
  • Reviews |

    Recent decades have seen an alarming rise in the incidence of autoimmune disease. In a Perspective, Matarese and colleagues discuss the evidence showing that changes in diet and metabolic workload can account for, at least in part, rises in the frequency of autoimmune disease.

    • Veronica De Rosa
    • , Antonio La Cava
    •  & Giuseppe Matarese
    Nature Immunology 18, 1190–1196
  • Research | | open

    NADPH oxidase NOX4 has been linked to poor cancer survival. Here the authors show that NOX4 regulates drug resistance in renal cancer carcinoma by regulating PKM2 and that NOX4 activity is allosterically activated by reduced mitochondrial ATP levels thus coupling energy metabolism to drug resistance.

    • Karthigayan Shanmugasundaram
    • , Bijaya K. Nayak
    • , William E. Friedrichs
    • , Dharam Kaushik
    • , Ronald Rodriguez
    •  & Karen Block
  • Research | | open

    MicroRNAs play an important role in stem cell fate and tumorigenesis. In this work, the authors show that miR-31 controls mammary stem cell self-renewal and tumorigenesis by simultaneously activating Wnt/β-catenin and repressing TGFβ signaling pathways.

    • Cong Lv
    • , Fengyin Li
    • , Xiang Li
    • , Yuhua Tian
    • , Yue Zhang
    • , Xiaole Sheng
    • , Yongli Song
    • , Qingyong Meng
    • , Shukai Yuan
    • , Liming Luan
    • , Thomas Andl
    • , Xu Feng
    • , Baowei Jiao
    • , Mingang Xu
    • , Maksim V. Plikus
    • , Xing Dai
    • , Christopher Lengner
    • , Wei Cui
    • , Fazheng Ren
    • , Jianwei Shuai
    • , Sarah E. Millar
    •  & Zhengquan Yu
  • Research | | open

    Thick filaments in skeletal muscle and heart are composed of myosin. The authors show that the length of thick filaments is defined by titin, and that alterations in titin length affect force generation and lead to dilated cardiomyopathy in mice.

    • Paola Tonino
    • , Balazs Kiss
    • , Josh Strom
    • , Mei Methawasin
    • , John E. Smith III
    • , Justin Kolb
    • , Siegfried Labeit
    •  & Henk Granzier

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