Diseases

Definition

Diseases are abnormal conditions that have a specific set of signs and symptoms. Diseases can have an external cause, such as an infection, or an internal cause, such as autoimmune diseases.

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Latest Research and Reviews

  • Research |

    Loss of BAF47 destabilizes the BAF complex on chromatin, and reintroduction of BAF47 leads to enhancer activation and Polycomb opposition at bivalent promoters. BAF47 loss affects BAF and PBAF complexes, which have distinct functions in regulation of enhancers and promoters.

    • Robert T Nakayama
    • , John L Pulice
    • , Alfredo M Valencia
    • , Matthew J McBride
    • , Zachary M McKenzie
    • , Mark A Gillespie
    • , Wai Lim Ku
    • , Mingxiang Teng
    • , Kairong Cui
    • , Robert T Williams
    • , Seth H Cassel
    • , He Qing
    • , Christian J Widmer
    • , George D Demetri
    • , Rafael A Irizarry
    • , Keji Zhao
    • , Jeffrey A Ranish
    •  & Cigall Kadoch
  • Research |

    The precise underpinnings of Parkinson's disease and other disorders associated with the accumulation of α-synuclein are unclear. This study shows that PrPC mediates α-synuclein-associated synaptic dysfunction and memory deficits. Blocking specific events in receptor biology rescued cognitive deficits in mice, suggesting new possibilities for intervention in synucleinopathies.

    • Diana G Ferreira
    • , Mariana Temido-Ferreira
    • , Hugo Vicente Miranda
    • , Vânia L Batalha
    • , Joana E Coelho
    • , Éva M Szegö
    • , Inês Marques-Morgado
    • , Sandra H Vaz
    • , Jeong Seop Rhee
    • , Matthias Schmitz
    • , Inga Zerr
    • , Luísa V Lopes
    •  & Tiago F Outeiro
  • Research |

    Wu et al. show that prosurvival BCL-2 proteins disrupt SUFU repression of GLI activity, leading to GLI target gene expression. BH3 mimetics disable GLI transcriptional activity driven by HH pathway mutations.

    • Xiaofeng Wu
    • , Li-shu Zhang
    • , Jason Toombs
    • , Yi-Chun Kuo
    • , John Tyler Piazza
    • , Rubina Tuladhar
    • , Quinn Barrett
    • , Chih-wei Fan
    • , Xuewu Zhang
    • , Loren D. Walensky
    • , Marcel Kool
    • , Steven Y. Cheng
    • , Rolf Brekken
    • , Joseph T. Opferman
    • , Douglas R. Green
    • , Tudor Moldoveanu
    •  & Lawrence Lum
  • Reviews |

    Emerging data indicate that exercise modulates cancer biology and disease outcomes; however, the molecular mechanisms are poorly established. In this Opinion article, the authors speculate on how exercise might reprogramme the tumour microenvironment to influence cancer hallmarks.

    • Graeme J. Koelwyn
    • , Daniela F. Quail
    • , Xiang Zhang
    • , Richard M. White
    •  & Lee W. Jones
    Nature Reviews Cancer 17, 545–549
  • Research |

    Diamond, Screaton and colleagues show that certain cross-reactive neutralizing antibodies to dengue virus have therapeutic activity against Zika virus infection in immune-privileged sites in vivo.

    • Estefania Fernandez
    • , Wanwisa Dejnirattisai
    • , Bin Cao
    • , Suzanne M Scheaffer
    • , Piyada Supasa
    • , Wiyada Wongwiwat
    • , Prabagaran Esakky
    • , Andrea Drury
    • , Juthathip Mongkolsapaya
    • , Kelle H Moley
    • , Indira U Mysorekar
    • , Gavin R Screaton
    •  & Michael S Diamond

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