Medical research

Definition

Medical research involves research in a wide range of fields, such as biology, chemistry, pharmacology and toxicology with the goal of developing new medicines or medical procedures or improving the application of those already available. It can be viewed as encompassing preclinical research (for example, in cellular systems and animal models) and clinical research (for example, clinical trials).

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Latest Research and Reviews

  • Research |

    A novel quantitative approach to identify intact glycopeptides from comparative proteomic data sets, allowing inference of complex glycan structures and direct mapping of them to sites within the associated proteins at the proteome scale.

    • Johannes Stadlmann
    • , Jasmin Taubenschmid
    • , Daniel Wenzel
    • , Anna Gattinger
    • , Gerhard Dürnberger
    • , Frederico Dusberger
    • , Ulrich Elling
    • , Lukas Mach
    • , Karl Mechtler
    •  & Josef M. Penninger
  • Reviews |

    NAFLD is growing in prevalence worldwide, and has emerged as a leading cause of end-stage liver disease in many countries. In this Review, the authors describe the global epidemiology of NAFLD, discuss associated risk factors and outline challenges for screening and management.

    • Zobair Younossi
    • , Quentin M. Anstee
    • , Milena Marietti
    • , Timothy Hardy
    • , Linda Henry
    • , Mohammed Eslam
    • , Jacob George
    •  & Elisabetta Bugianesi
  • Reviews |

    Chimeric antigen receptor (CAR)-T-cell therapies are showing great promise in the treatment of cancer, particularly B-cell malignancies, but are associated with characteristic, potentially fatal toxicities, principally cytokine-release syndrome, CAR-T-cell-related encephalopathy syndrome, and haemophagocytic lymphohistiocytosis/macrophage-activation syndrome. Herein, the CAR-T-cell-therapy-associated TOXicity (CARTOX) Working Group, comprising multidisciplinary investigators from various institutions with clinical experience in the use of a range of CAR-T-cell platforms, review these acute toxicities and provide monitoring, grading, and management recommendations.

    • Sattva S. Neelapu
    • , Sudhakar Tummala
    • , Partow Kebriaei
    • , William Wierda
    • , Cristina Gutierrez
    • , Frederick L. Locke
    • , Krishna V. Komanduri
    • , Yi Lin
    • , Nitin Jain
    • , Naval Daver
    • , Jason Westin
    • , Alison M. Gulbis
    • , Monica E. Loghin
    • , John F. de Groot
    • , Sherry Adkins
    • , Suzanne E. Davis
    • , Katayoun Rezvani
    • , Patrick Hwu
    •  & Elizabeth J. Shpall
  • Research | | open

    Neutrophils are important modulators of tissue damage after intracerebral hemorrhage (ICH), but how this function is regulated is not clear. Here, the authors show interleukin-27 promotes the tissue-protecting functions of neutrophils via, at least partly, the induction of lactoferrin to present a potential therapy for ICH.

    • Xiurong Zhao
    • , Shun-Ming Ting
    • , Chin-Hsuan Liu
    • , Guanghua Sun
    • , Marian Kruzel
    • , Meaghan Roy-O’Reilly
    •  & Jaroslaw Aronowski
  • Research | | open

    Susceptibility to infectious diseases is, among others, influenced by the genetic landscape of the host. Here, Tian and colleagues perform genome-wide association studies for 23 common infections and find 59 risk loci for 17 of these, both within the HLA region and non-HLA loci.

    • Chao Tian
    • , Bethann S. Hromatka
    • , Amy K. Kiefer
    • , Nicholas Eriksson
    • , Suzanne M. Noble
    • , Joyce Y. Tung
    •  & David A. Hinds

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