Rheumatology

Definition

Rheumatology is a subspecialty of internal medicine focusing on the diagnosis, treatment and medical management of patients with rheumatic diseases that affect the musculoskeletal system.

Latest Research and Reviews

  • Research |

    Yuta Kochi and colleagues perform expression quantitative trait loci (eQTL) analysis on five subsets of immune cells individually sorted from blood from 105 individuals. They develop an integrated analysis pipeline of expression and epigenomic data along with gene association to identify cell-specific candidate causal genes and apply this to rheumatoid arthritis.

    • Kazuyoshi Ishigaki
    • , Yuta Kochi
    • , Akari Suzuki
    • , Yumi Tsuchida
    • , Haruka Tsuchiya
    • , Shuji Sumitomo
    • , Kensuke Yamaguchi
    • , Yasuo Nagafuchi
    • , Shinichiro Nakachi
    • , Rika Kato
    • , Keiichi Sakurai
    • , Hirofumi Shoda
    • , Katsunori Ikari
    • , Atsuo Taniguchi
    • , Hisashi Yamanaka
    • , Fuyuki Miya
    • , Tatsuhiko Tsunoda
    • , Yukinori Okada
    • , Yukihide Momozawa
    • , Yoichiro Kamatani
    • , Ryo Yamada
    • , Michiaki Kubo
    • , Keishi Fujio
    •  & Kazuhiko Yamamoto
  • Research |

    An antibody against the pituitary hormone Fsh reduces adiposity and increases thermogenesis in ovariectomized mice or mice fed a high-fat diet.

    • Peng Liu
    • , Yaoting Ji
    • , Tony Yuen
    • , Elizabeth Rendina-Ruedy
    • , Victoria E. DeMambro
    • , Samarth Dhawan
    • , Wahid Abu-Amer
    • , Sudeh Izadmehr
    • , Bin Zhou
    • , Andrew C. Shin
    • , Rauf Latif
    • , Priyanthan Thangeswaran
    • , Animesh Gupta
    • , Jianhua Li
    • , Valeria Shnayder
    • , Samuel T. Robinson
    • , Yue Eric Yu
    • , Xingjian Zhang
    • , Feiran Yang
    • , Ping Lu
    • , Yu Zhou
    • , Ling-Ling Zhu
    • , Douglas J. Oberlin
    • , Terry F. Davies
    • , Michaela R. Reagan
    • , Aaron Brown
    • , T. Rajendra Kumar
    • , Solomon Epstein
    • , Jameel Iqbal
    • , Narayan G. Avadhani
    • , Maria I. New
    • , Henrik Molina
    • , Jan B. van Klinken
    • , Edward X. Guo
    • , Christoph Buettner
    • , Shozeb Haider
    • , Zhuan Bian
    • , Li Sun
    • , Clifford J. Rosen
    •  & Mone Zaidi
  • Research | | open

    Skeletal muscle atrophy can occur in response to stimuli such as inactivity, fasting, and ageing. Here the authors show that expression of microRNA-29b promotes muscle atrophy by targeting IGF-1 and PI3K, and that its inhibition attenuates atrophy induced by denervation and immobilization in mice.

    • Jin Li
    • , Mun Chun Chan
    • , Yan Yu
    • , Yihua Bei
    • , Ping Chen
    • , Qiulian Zhou
    • , Liming Cheng
    • , Lei Chen
    • , Olivia Ziegler
    • , Glenn C. Rowe
    • , Saumya Das
    •  & Junjie Xiao
  • Reviews |

    A growing body of evidence supports a shift away from bed rest and inactivity to prescribing physical activity for children and adolescents with rheumatic diseases. Increasing physical activity levels, as well as reducing hypoactivity, can improve symptoms and outcomes in this paediatric population.

    • Bruno Gualano
    • , Eloisa Bonfa
    • , Rosa M. R. Pereira
    •  & Clovis A. Silva

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