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Effectiveness of EGFR treatment is impaired through an early adaptive response. TNF–JNK–Axl–ERK signaling contributes to this primary resistance to EGFR inhibition and might serve as novel target to improve EGFR inhibition.
Van Groningen et al. unravel the epigenetic nature of intratumoural heterogeneity in neuroblastoma, which comprises both lineage-committed adrenergic cells and undifferentiated mesenchymal cells that are defined by unique super-enhancer transcriptional networks and gene expression signatures.
A retrospective population-based cohort study has shown that outcomes were worse for patients with neuropathic pain who received long-term opioid treatment than for those who received short-term opioid treatment. The finding highlights a need for improved pain education for non-specialists and for more-effective therapies.