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γδ T cells are found mainly in epithelial tissues, where they have crucial roles in tissue homeostasis and repair. Here, the authors describe how γδ T cells are activated and regulated in epithelial tissues, such as the skin and intestine, to mediate host microbial tolerance and provide protection against infection.
MANF is a neurotrophic factor that is secreted but also mediates the unfolded protein response acting intracellularly. Here, the authors show that MANF expression in the brain is influenced by nutritional cues, and hypothalamic MANF influences food intake and systemic energy homeostasis.
KRAS oncogene mutations are commonly encountered in pancreatic ductal adenocarcinoma, driving tumour initiation, proliferation, progression and metastasis. Human exosomes engineered to deliver small interfering RNA silencing KRASG12D are highly efficient at specifically targeting pancreatic cancer cells to dramatically reduce RAS activation, cancer cell proliferation and metastatic processes.