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Diseases are abnormal conditions that have a specific set of signs and symptoms. Diseases can have an external cause, such as an infection, or an internal cause, such as autoimmune diseases.
A therapeutic strategy that alters gene expression in a rare and severe neurodevelopmental condition has been tested in stem-cell-based models of the disease, and has been shown to correct genetic and cellular defects.
SARS-CoV-2 infection can be associated with ‘brain fog’ and persistent neurologic disease, especially in the elderly, with the possibility of direct viral particle interference with normal synaptic transmission.
T cell infiltration in the tumour microenvironment (TME) is a prerequisite for sustained antitumour immune responses. However, identifying predictive biomarkers that quantify T cell infiltration and the presence of proinflammatory TMEs associated with immune-checkpoint inhibitor (ICI) response for clinical implementation has proved challenging. Here, we highlight a study that validates a T cell-to-stroma enrichment score generated from RNA sequencing data as a novel biomarker for ICI response in patients with urothelial carcinoma.
This PrimeView highlights the epidemiology of severe cutaneous adverse reactions, and summarizes the mechanisms, diagnosis and management of this disorder. It accompanies the Primer article on this topic by Hung et al.