Skin diseases

Definition

Skin diseases are pathologic conditions that affect the body's surfaces (also called the integument), including skin, hair, nails and associated glands. They can involve all layers of the skin and have numerous aetiologies such as infections, tumours or inflammation.

Latest Research and Reviews

  • Research |

    Gilot et al. have found that TYRP1 mRNA, in addition to coding for TYRP1 protein, can promote melanoma by sequestering the tumour suppressor miR-16, thus de-repressing the mRNA transcription of miR-16 target RAB17, which is involved in melanoma cell proliferation.

    • David Gilot
    • , Mélodie Migault
    • , Laura Bachelot
    • , Fabrice Journé
    • , Aljosja Rogiers
    • , Emmanuelle Donnou-Fournet
    • , Ariane Mogha
    • , Nicolas Mouchet
    • , Marie-Laure Pinel-Marie
    • , Bernard Mari
    • , Tristan Montier
    • , Sébastien Corre
    • , Arthur Gautron
    • , Florian Rambow
    • , Petra El Hajj
    • , Rania Ben Jouira
    • , Sophie Tartare-Deckert
    • , Jean-Christophe Marine
    • , Brice Felden
    • , Ghanem Ghanem
    •  & Marie-Dominique Galibert
  • Reviews |

    Several types of human tumour are dependent on mutations in BRAF. This led to the development of RAF inhibitors, which prolong patient survival but are limited by resistance. This Review discusses the recent advances in our understanding of BRAF oncogenic signalling, RAF inhibitor activity and the implementation of this knowledge for the development of next-generation inhibitors.

    • Zoi Karoulia
    • , Evripidis Gavathiotis
    •  & Poulikos I. Poulikakos
  • Research |

    The identification of an ERK2–JUNB–FRA1 signalling pathway that drives addiction to therapeutic drugs in cancer cells, and an ERK2-dependent phenotype switch that precedes cell death after drug withdrawal, may help to guide therapies that exploit the addiction phenotype.

    • Xiangjun Kong
    • , Thomas Kuilman
    • , Aida Shahrabi
    • , Julia Boshuizen
    • , Kristel Kemper
    • , Ji-Ying Song
    • , Hans W. M. Niessen
    • , Elisa A. Rozeman
    • , Marnix H. Geukes Foppen
    • , Christian U. Blank
    •  & Daniel S. Peeper
    Nature 550, 270–274

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