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A growing body of evidence supports a shift away from bed rest and inactivity to prescribing physical activity for children and adolescents with rheumatic diseases. Increasing physical activity levels, as well as reducing hypoactivity, can improve symptoms and outcomes in this paediatric population.
When considering the role of imaging in the management of symptomatic, peripheral joint osteoarthritis (OA) in clinical practice, clinicians should be aware that radiography has its drawbacks, and also consider that the use of advanced imaging techniques such as MRI should not be discouraged.
Mechanistic studies have implicated the alternative complement pathway, specifically C5a receptor activation, in the pathogenesis of anti-neutrophil cytoplasmic antibody-associated vasculitis. Results from a phase 2 trial suggest that C5a receptor blockade could enable the reduced use or complete withdrawal of steroids from induction protocols.