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Central hypothyroidism is characterized by a defect in thyroid hormone secretion caused by insufficient stimulation of the thyroid gland by TSH. Here, Beck-Peccoz and colleagues discuss the causes of central hypothyroidism and highlight areas where improvement is needed regarding diagnosis and treatment.
Lipid turnover in tissues can be calculated from ratios of different carbon isotopes. Here the authors use this approach to study lipid turnover in two distinct adipose tissue depots and find that, in obese individuals, visceral fat is more lipolytic than subcutaneous fat.
The concept of food addiction as an explanation for the rise in obesity has become increasingly popular. In this Opinion article, Graham Finlayson critically evaluates the food addiction hypothesis and highlights several problems with its use.
A recent advance has led to the development of microfluidically linked microphysiological culture systems that mimic the complex dynamics and interdependent physiology of the various organs that comprise the female reproductive tract. This microfluidic culture platform offers an unprecedented way to study female reproductive biology and develop new reproductive therapeutics.
Diabetes mellitus is one of the largest epidemics the world faces and is now an important public health challenge. The 'SEARCH for Diabetes in Youth' consortium now reports that, between 2002 and 2012, incidence rates of type 1 diabetes mellitus and type 2 diabetes mellitus grew among all youth in the USA, more so in ethnic minorities.