Featured
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Review Article |
Mitochondrial function and gastrointestinal diseases
Mitochondria of the intestinal epithelium are vital in intestinal health and disease. This Review provides a comprehensive overview of intestinal epithelial cell mitochondrial dysfunction in inflammatory bowel diseases and colorectal cancer and discusses mitochondrial-targeted therapeutics for these diseases.
- Parsa S. Haque
- , Neeraj Kapur
- & Arianne L. Theiss
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Perspective |
Future direction of total neoadjuvant therapy for locally advanced rectal cancer
In this article, the authors discuss the use of total neoadjuvant therapy for locally advanced rectal cancer. They highlight ongoing trials and discuss future treatment options, including the potential use of multi-omics and artificial intelligence to facilitate treatment selection and prediction of response.
- Yoshinori Kagawa
- , J. Joshua Smith
- & Takayuki Yoshino
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Comment |
Live bacterial therapeutics for detection and treatment of colorectal cancer
Live microorganisms can be manipulated and engineered for colorectal cancer detection and treatment through methods such as faecal microbiota transplantation, native bacteria engineering and synthetic circuit engineering. Although promising, substantial effort is required to translate these approaches for clinical use.
- Joanna Zhang
- , Jeff Hasty
- & Amir Zarrinpar
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Review Article |
RNA modification-mediated mRNA translation regulation in liver cancer: mechanisms and clinical perspectives
RNA modifications are crucial in regulating mRNA translation. This Review provides a comprehensive overview of the molecular mechanisms underlying RNA modifications in mRNA translation regulation, and discusses the diagnostic and therapeutic potentials of targeting RNA modifications for liver cancer management.
- Shuibin Lin
- & Ming Kuang
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Year in Review |
New options for late-line treatment of metastatic colorectal cancer
Metastatic colorectal cancer is a heterogeneous disease associated with poor patient outcomes. Although the past decade has seen few first-line treatment advances, key studies published in 2023 established new options for late-line therapy of the disease with and without oncogenic drivers, thus expanding the continuum of care in metastatic colorectal cancer.
- Sara Lonardi
- & Filippo Pietrantonio
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Research Highlight |
Tumour-associated macrophages and pancreatic cancer: an inflammatory loop
- Jordan Hindson
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Review Article |
Preoperative chemotherapy, radiotherapy and surgical decision-making in patients with borderline resectable and locally advanced pancreatic cancer
In this Review, Besselink and colleagues discuss preoperative chemotherapy, radiotherapy and surgical decision-making in patients with borderline resectable pancreatic cancer and locally advanced pancreatic cancer, including disease staging and response evaluation.
- Thomas F. Stoop
- , Rutger T. Theijse
- & Marc G. Besselink
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Perspective |
Reduction in colorectal cancer incidence by screening endoscopy
This Perspective explores the relationship between screening endoscopy and colorectal cancer incidence, examining available evidence and offering insights into the discrepancies between real-world and trial evidence alongside potential pitfalls with interpreting the data.
- Hermann Brenner
- , Thomas Heisser
- & Michael Hoffmeister
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Review Article |
Changing epidemiology of colorectal cancer — birth cohort effects and emerging risk factors
In this Review, Murphy and Zaki discuss changes in the incidence and mortality of colorectal cancer, including trends by age and birth cohort, and consider the contributions of early-life exposures and emerging risk factors.
- Caitlin C. Murphy
- & Timothy A. Zaki
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Review Article |
Friend or foe? The elusive role of hepatic stellate cells in liver cancer
Hepatic stellate cells (HSCs) drive liver fibrosis and are closely linked to liver cancer development. This comprehensive Review provides an in-depth analysis of the specific characteristics of HSCs in cancer, highlighting therapeutic implications based on progress in clarifying HSC biology.
- Bruno Cogliati
- , Chittampalli N. Yashaswini
- & Scott L. Friedman
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Review Article |
Hepatocellular carcinoma surveillance — utilization, barriers and the impact of changing aetiology
In this Review, Huang et al. discuss the current status of hepatocellular carcinoma surveillance, the remaining challenges, including the changing aetiology of liver disease, and strategies to improve the utilization and quality of surveillance.
- Daniel Q. Huang
- , Amit G. Singal
- & Rohit Loomba
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Research Highlight |
Epigenetic plasticity associated with pancreatic tumorigenesis in mice
- Jordan Hindson
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Clinical Outlook |
Current status of colon capsule endoscopy in clinical practice
Colon capsule endoscopy (CCE) is used for restricted indications only. Growing demand for out-of-hospital treatment combined with technical and clinical improvements in quality has made a wider use plausible. Artificial intelligence-supported footage analysis and quality assessment might further improve quality and reduce the price of CCE to a competitive level.
- Anastasios Koulaouzidis
- & Gunnar Baatrup
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Review Article |
The gasdermin protein family: emerging roles in gastrointestinal health and disease
Gasdermins (GSDMs) are proteins primarily involved in pyroptosis, among other cellular functions. This Review provides a comprehension summary of GSDM biology, focusing on the gastrointestinal tract and addressing clinical implications and future research.
- Giuseppe Privitera
- , Nitish Rana
- & Theresa T. Pizarro
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Consensus Statement |
Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance
Preclinical research is required to improve our understanding of cholangiocarcinoma (CCA). In this Consensus Statement, a task force of experts provides recommendations on the criteria for preclinical models of CCA to increase disease understanding and help to develop novel therapeutic approaches.
- Diego F. Calvisi
- , Luke Boulter
- & Yoshimasa Saito
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Review Article |
Immunology and immunotherapy of cholangiocarcinoma
Cholangiocarcinoma is the second most common primary liver cancer, and its incidence is rising worldwide. This Review discusses the immunology of cholangiocarcinoma and provides a comprehensive overview of the preclinical and clinical immunotherapy studies.
- Tim F. Greten
- , Robert Schwabe
- & Xin W. Wang
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Review Article |
Therapeutic landscape and future direction of metastatic colorectal cancer
The therapeutic landscape of metastatic colorectal cancer (mCRC) is changing. This Review provides a comprehensive overview discussing the current mCRC advances in precision oncology and suggests a treatment strategy for mCRC with rare genomic alterations.
- Hideaki Bando
- , Atsushi Ohtsu
- & Takayuki Yoshino
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Review Article |
Updated epidemiology of gastrointestinal cancers in East Asia
There is an increasing burden of gastrointestinal cancers in East Asia. This Review provides an updated summary of the epidemiology of gastrointestinal cancers in this region and discusses risk factors and implications for prevention.
- Junjie Huang
- , Don Eliseo Lucero-Prisno III
- & Martin C. S. Wong
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In Brief |
Phase III results for first-line treatment for metastatic colorectal cancer
- Eleni Kotsiliti
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In Brief |
Elucidating the genetic and epigenetic evolution and phenotypic plasticity of colorectal tumours
- Jordan Hindson
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Research Highlight |
Targeting hyperactive tRNA modification improves anti-PD1 efficacy
- Eleni Kotsiliti
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Review Article |
Current developments in gastric cancer: from molecular profiling to treatment strategy
Gastric and gastro-oesophageal cancer is a leading cause of cancer-related death worldwide with a poor prognosis. This Review provides a comprehensive overview of current treatment strategies set on a molecular basis, and discusses future therapeutic avenues.
- Maria Alsina
- , Virginia Arrazubi
- & Josep Tabernero
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Review Article |
Nerves in gastrointestinal cancer: from mechanism to modulations
The influence of nerves on cancer is beginning to be understood. This Review discusses emerging insights into the role of the nervous system in gastrointestinal cancer and of nerves as components of the tumour microenvironment, highlighting underlying mechanisms and its potential as a therapeutic target.
- Nathalie Vaes
- , Musa Idris
- & Veerle Melotte
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