Featured
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Review Article |
Current developments in gastric cancer: from molecular profiling to treatment strategy
Gastric and gastro-oesophageal cancer is a leading cause of cancer-related death worldwide with a poor prognosis. This Review provides a comprehensive overview of current treatment strategies set on a molecular basis, and discusses future therapeutic avenues.
- Maria Alsina
- , Virginia Arrazubi
- & Josep Tabernero
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In Brief |
Promising phase I interim results for CAR T cells in gastrointestinal cancers
- Katrina Ray
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Review Article |
The immune microenvironment in gastric adenocarcinoma
In this Review, the authors describe how the chronic inflammatory microenvironment in the gastric mucosal epithelia during Helicobacter pylori infection can stimulate intracellular signalling pathways that lead to the development of gastric adenocarcinoma.
- Yana Zavros
- & Juanita L. Merchant
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In Brief |
Nivolumab plus chemotherapy for advanced gastric cancer and oesophageal adenocarcinoma
- Jordan Hindson
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Research Highlight |
New markers and models of premalignancy and the early development of gastric cancer
- Katrina Ray
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News & Views |
Gastric cancer: evidence boosts Helicobacter pylori eradication
The efficacy of Helicobacter pylori eradication therapy for the prevention of preneoplastic lesions in gastric cancer remains controversial. A new placebo-controlled trial and a large-scale observational study tackle this problem and show the positive effects of eradication therapy.
- Hidekazu Suzuki
- & Juntaro Matsuzaki
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Review Article |
Acid and the basis for cellular plasticity and reprogramming in gastric repair and cancer
The stomach responds to injury via two main patterns, the superficial response and the glandular response. In this Review, Sáenz and Mills discuss cellular plasticity and reprogramming in the stomach in the context of disease (such as gastric cancer) and during repair and homeostasis.
- José B. Sáenz
- & Jason C. Mills
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In Brief |
The ATTRACTION of nivolumab for gastric and gastro-oesophageal junction cancer
- Katrina Ray
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News & Views |
The gastric microbiota — bacterial diversity and implications
Although Helicobacter pylori is associated with gastric cancer, bacterial communities that reside in the stomach are mostly unacknowledged. A new study shows that some gastric bacterial communities have emigrated from our mouth, prefer certain neighbours and prefer certain environments. By understanding the interactions of these bacteria, we hope to understand the environment most conducive to gastric cancer carcinogenesis.
- Manish A. Shah
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Research Highlight |
R-spondin 3 is a critical regulator of gastric antral stem cell homeostasis
- Hugh Thomas
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Review Article |
How to stomach an epigenetic insult: the gastric cancer epigenome
Gastric cancer is a deadly malignancy and accumulating evidence suggests that epigenetic abnormalities promote carcinogenesis. Here, the authors summarize the gastric cancer epigenome, highlighting key advances from studies of DNA methylation and histone modifications, and how these findings might lead to therapeutic opportunities.
- Nisha Padmanabhan
- , Toshikazu Ushijima
- & Patrick Tan
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Review Article |
Population screening and treatment of Helicobacter pylori infection
Helicobacter pyloriremains an important human pathogen with links to both malignant (gastric cancer) and non-malignant diseases (such as peptic ulcer). Here, the authors discuss issues related to implementation of population screening and eradication ofH. pyloriinfection.
- Anthony O'Connor
- , Colm A. O'Morain
- & Alexander C. Ford
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News & Views |
Pathogenic enablers — toxic relationships in the stomach
Chronic infection with Helicobacter pylori is the strongest known risk factor for the development of gastric cancer. Saju et al. shed new light on mechanisms by which Epstein–Barr virus, a viral initiator of gastric cancer, potentiates the oncogenic effects of Helicobacter pylori in the stomach.
- Lydia E. Wroblewski
- & Richard M. Peek Jr
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Research Highlight |
Metformin improves survival and recurrence rate in patients with diabetes and gastric cancer
- Claire Greenhill
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Review Article |
Genetics of gastric cancer
Gastric cancer accounts for a notable proportion of cancer mortality around the world. Over the past few decades, advances in technology and high-throughput analysis have improved understanding of the molecular aspects of the pathogenesis of gastric cancer. This Review discusses these genetic aspects of the pathogenesis of gastric cancer.
- Mairi H. McLean
- & Emad M. El-Omar
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Research Highlight |
New molecular classification of gastric adenocarcinoma proposed by The Cancer Genome Atlas
- Mina Razzak
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Research Highlight |
New biologic therapy effective as second-line treatment in gastric cancer
- Katherine Smith
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In Brief |
Breath test for gastric cancer
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Research Highlight |
Integrated epigenomic analysis sheds light on role of BMP4 in regulating cisplatin sensitivity in gastric cancer
- Natalie J. Wood
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News & Views |
Localized gastric cancer—a CLASSIC shift in the paradigm?
The management of localized gastric cancer has evolved globally to region-specific approaches with little convergence. The unifying theme, however, is that surgery alone is insufficient for best outcomes, and adjunctive therapy must be offered. Multidisciplinary evaluation before therapy is highly recommended, but postoperative approaches are not conducive to this scenario.
- Mariela A. Blum
- & Jaffer A. Ajani
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News & Views |
Secondary prevention of gastric cancer
The natural history of 'epidemic' intestinal-type gastric cancer provides consistent data that enable clinicians to design multidisciplinary strategies for secondary prevention. A recent paper by Dinis-Ribeiro et al. reports guidelines for the management of patients with precancerous stomach lesions.
- Massimo Rugge
- , Matteo Fassan
- & David Y. Graham
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Research Highlight |
Bone-marrow-derived cells could cause gastric preneoplasia in chronic Helicobacter pylori infection
- Andy McLarnon
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Research Highlight |
ESD is associated with a moderate risk of deep vein thrombosis that may be determined by D-dimer levels
- Katherine Smith
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Review Article |
Anti-HER agents in gastric cancer: from bench to bedside
Despite some advances, the search for effective treatment modalities for advanced gastric and gastro-esophageal junction cancer (GEJC) is far from over. However, using biologic agents to target key molecular pathways, such as those regulated by human epidermal growth factor receptor (HER) family members, may be an effective approach. This Review briefly describes HER biology, summarizes available data regarding the clinical activity of anti-HER agents and their use in gastric cancer and GEJC, and provides insight into treatment personalization strategies.
- Lorenzo Fornaro
- , Maurizio Lucchesi
- & Alfredo Falcone
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Research Highlight |
FAK autophosphorylation independently predicts recurrence of gastric cancer
- Shreeya Nanda
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Review Article |
Mechanisms of disease: Helicobacter pylori virulence factors
Helicobacter pylorihas an essential role in the development of various gastroduodenal diseases, but only a small proportion of people infected withH. pylori develop these diseases. In this Review, Yoshio Yamaoka discusses current knowledge of the H. pylorivirulence factors CagA, VacA, OipA and DupA. In particular, he considers how these virulence factors contribute to differing geographic gastric cancer disease patterns and to the development of both gastric cancer and duodenal ulcer.
- Yoshio Yamaoka
Exploring human gastric cancers through organoid culture
A chief role for Lgr5+ cells
Settling the stomach — tracing gastric stem cells
DARPP-32: a link between infection and gastric cancer
Dysregulation of RNA editing in gastric cancer
Breathing a sigh of relief for noninvasive cancer detection
Revealing the genomic landscape of gastric cancer
Gene fusion identified in gastric cancer
Helicobacter pylori ancestry associated with cancer risk
Value of CLE for gastric cancer detection