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Colorectal cancer

Mutations linked to chemotherapy resistance in colorectal cancer

Nature Reviews Gastroenterology & Hepatology volume 20, page 269 (2023)Cite this article

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Resistance to treatment for metastatic colorectal cancer (mCRC) with trifluridine–tipiracil (FTD–TPI) is associated with mutations in KRAS codon G12 (KRASG12), new research has shown. The findings demonstrate that genomic-based markers can be used to guide chemotherapy.

Responses to cancer treatments vary. Genomics has identified predictive biomarkers of responses to many targeted and immune therapies, but similar markers for chemotherapies are lacking. In their new study, Emile Voest, Nicola Valeri and colleagues set out to identify genomic markers of response to chemotherapy with FTD–TPI for mCRC.

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Original article

  • van de Haar, J. et al. Codon-specific KRAS mutations predict survival benefit of trifluridine/tipiracil in metastatic colorectal cancer. Nat. Med. 29, 605–614 (2023)

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  1. Nature Reviews Gastroenterology & Hepatology http://www.nature.com/nrgastro/

    Ian Fyfe

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  1. Ian Fyfe
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Correspondence to Ian Fyfe.

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Fyfe, I. Mutations linked to chemotherapy resistance in colorectal cancer. Nat Rev Gastroenterol Hepatol 20, 269 (2023). https://doi.org/10.1038/s41575-023-00772-5

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