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Open Access
Featured
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Technology Feature |
How open-source software could finally get the world’s microscopes speaking the same language
A plethora of standards mean shareable and verifiable microscopy data often get lost in translation. Biologists are working on a solution.
- Michael Brooks
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Article
| Open AccessProteome census upon nutrient stress reveals Golgiphagy membrane receptors
A proteomics analysis demonstrates that, during nutrient stress, mammalian cells prioritize degradation by autophagy of membrane proteins and identifies receptors that mediate this process at the Golgi and also have a role in Golgi remodelling during neuronal differentiation.
- Kelsey L. Hickey
- , Sharan Swarup
- & J. Wade Harper
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News Explainer |
How Dolly the sheep’s legacy lives on: CRISPR cattle and cloned camels
Dolly-style animal cloning underpins CRISPR livestock, but changes loom for the field.
- Heidi Ledford
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Research Briefing |
Using CRISPR to study gene function aids understanding of 22q11.2 deletion syndrome
Most high-throughput assays to investigate the role of genes in disease involve in vitro cell models. Now a technology that targets CRISPR–Cas9 gene editing to specific cells in mice, and analyses transcriptional effects in single nuclei, has led to fresh insights into the genes involved in 22q11.2 deletion syndrome.
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Article
| Open AccessTransgenic ferret models define pulmonary ionocyte diversity and function
Conditional genetic ferret models enable ionocyte lineage tracing, ionocyte ablation and ionocyte-specific deletion of CFTR to elucidate the roles of pulmonary ionocyte biology and function during human health and disease.
- Feng Yuan
- , Grace N. Gasser
- & John F. Engelhardt
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Article
| Open AccessTranscriptional linkage analysis with in vivo AAV-Perturb-seq
An in vivo single-cell CRISPR screening method identifies transcriptional phenotypes of 22q11.2 deletion syndrome associated with a broad dysregulation of a class of disease susceptibility genes that are important for RNA processing and synaptic function.
- Antonio J. Santinha
- , Esther Klingler
- & Randall J. Platt
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Technology Feature |
Catching proteins at play: the method revealing the cell’s inner mysteries
Cryo-electron tomography is a hugely promising tool in visual proteomics — if researchers can work out what they are seeing.
- Michael Eisenstein
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Book Review |
Geneticist J. Craig Venter: ‘I consider retirement tantamount to death’
The human genome ‘maverick’ talks sequencing the ocean, setting up a health-screening company after checking his own genes — and why he has no plans to stop.
- Heidi Ledford
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News |
Super-precise CRISPR tool enters US clinical trials for the first time
Base editing, which makes specific changes to a cell’s genome, is put to the test in CAR-T-cell treatments for leukaemia.
- Heidi Ledford
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News Q&A |
UFO sightings: how NASA can bring science to the debate
An astrophysicist who advised the agency talks to Nature about ways to bring rigour to reports of ‘unidentified anomalous phenomena’.
- Alexandra Witze
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Article |
Assembly of 43 human Y chromosomes reveals extensive complexity and variation
De novo assemblies of 43 Y chromosomes spanning 182,900 years of human evolution reveal considerable diversity in the size and structure of the human Y chromosome.
- Pille Hallast
- , Peter Ebert
- & Charles Lee
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Technology Feature |
The quest to map the mouse brain
By combining single-cell sequencing with methods to map the spatial location of gene expression, scientists are unravelling the extraordinary cellular diversity of the brain.
- Diana Kwon
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Article
| Open AccessDirect observation of the conformational states of PIEZO1
The plasma membrane can expand the blades of the PIEZO1 ion channel, impacting channel activation.
- Eric M. Mulhall
- , Anant Gharpure
- & Ardem Patapoutian
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Technology Feature |
Sharp resolution, big samples: ExA-SPIM microscope accelerates brain imaging
An innovative microscopy technique bridges the gap between field of view and resolution.
- Alla Katsnelson
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News |
This moss survived 165 million years — and now it's under threat from climate change
Ancient plant survived the formation of the Himalayas, but might now be facing extinction.
- Jude Coleman
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Article
| Open AccessNo evidence for magnetic field effects on the behaviour of Drosophila
Following testing of magnetic field effects on 97,658 flies moving in a two-arm maze and on 10,960 flies performing spontaneous escape behaviour (negative geotaxis), no evidence was found for magnetically sensitive behaviour in Drosophila.
- Marco Bassetto
- , Thomas Reichl
- & Henrik Mouritsen
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Book Review |
Anna Atkins: pioneering botanical photographer who captured algae and ferns in ghostly blue images
A compilation of 550 original plates reveals the dedicated work of the nineteenth-century woman who was the first to publish a book with cyanotypes of specimens.
- Georgina Ferry
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News |
AI search of Neanderthal proteins resurrects ‘extinct’ antibiotics
Scientists identify protein snippets made by extinct hominins.
- Saima Sidik
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Article
| Open AccessMega-scale experimental analysis of protein folding stability in biology and design
Large-scale assays using cDNA display proteolysis are used to measure the folding stabilities of protein domains, providing a method to quantify the effects of mutations on protein folding, with applications in protein design.
- Kotaro Tsuboyama
- , Justas Dauparas
- & Gabriel J. Rocklin
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Article |
High-throughput Oligopaint screen identifies druggable 3D genome regulators
High-throughput DNA or RNA labelling with optimized Oligopaints (HiDRO) reveals more than 300 factors that influence genome folding during interphase, including 43 genes that were validated as either increasing or decreasing interactions between topologically associating domains.
- Daniel S. Park
- , Son C. Nguyen
- & Eric F. Joyce
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News |
Developing human embryos imaged at highest-ever resolution
Non-invasive imaging approach could lead to innovations in embryo screening.
- Miryam Naddaf
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Article
| Open AccessEvolution of a minimal cell
An engineered minimal cell evolves to escape the negative consequences of genome streamlining.
- R. Z. Moger-Reischer
- , J. I. Glass
- & J. T. Lennon
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Outlook |
How genetically modified mosquitoes could eradicate malaria
Gene-drive technology that can spread antimalarial modifications throughout mosquito populations is maturing, but there are questions to answer before it can be used in the wild.
- Sam Jones
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News |
Ancient-DNA researcher fired for ‘serious misconduct’ lands new role
Former co-workers have expressed shock that Charles Sturt University in southeastern Australia has appointed Alan Cooper to its faculty.
- Dyani Lewis
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Article |
Continuous synthesis of E. coli genome sections and Mb-scale human DNA assembly
BAC stepwise insertion synthesis (BASIS) can be used to build synthetic genomes for diverse organisms, and continuous genome synthesis (CGS) enables the rapid synthesis of entire Escherichia coli genomes from functional designs.
- Jérôme F. Zürcher
- , Askar A. Kleefeldt
- & Jason W. Chin
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Article |
A spatially resolved single-cell genomic atlas of the adult human breast
The Human Breast Cell Atlas identifies 12 major breast cell types and 58 biological cell states, revealing abundant pericyte, endothelial and immune cell populations, and highly diverse luminal epithelial cell states.
- Tapsi Kumar
- , Kevin Nee
- & Nicholas Navin
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Article
| Open AccessSingle-cell quantification of ribosome occupancy in early mouse development
A single-cell ribosome profiling method can provide data at the level of allele-specific ribosome engagement in early development.
- Hakan Ozadam
- , Tori Tonn
- & Can Cenik
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Article
| Open AccessA pangenome reference of 36 Chinese populations
A study reports data from the first phase of the Chinese Pangenome Consortium including 116 de novo assemblies from 58 core samples representing 36 minority Chinese ethnic groups.
- Yang Gao
- , Xiaofei Yang
- & Shuhua Xu
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Article |
Genome editing of a rice CDP-DAG synthase confers multipathogen resistance
Editing of a rice gene that has a role in phospholipid synthesis has endowed rice plants with broad-spectrum resistance to disease, including protection from common bacterial and fungal pathogens, without decreasing the yield.
- Gan Sha
- , Peng Sun
- & Guotian Li
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Technology Feature |
Powerful microscope captures motor proteins in unprecedented detail
Called MINFLUX, the super-resolution method allows researchers to track molecules under cellular conditions.
- Amanda Heidt
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Article |
Hydration solids
A study shows that water can control macroscopic properties of biological materials through the hydration force, giving rise to a distinct class of solid matter with unusual properties.
- Steven G. Harrellson
- , Michael S. DeLay
- & Ozgur Sahin
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Article
| Open AccessUltraviolet radiation shapes dendritic cell leukaemia transformation in the skin
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) arises from clonal (premalignant) haematopoietic precursors in the bone marrow, and BPDCN skin tumours first develop at sun-exposed anatomical sites and are distinguished by clonally expanded mutations induced by ultraviolet radiation.
- Gabriel K. Griffin
- , Christopher A. G. Booth
- & Andrew A. Lane
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Article |
Indefinite and bidirectional near-infrared nanocrystal photoswitching
This study reports unlimited near-infrared photoswitching in inorganic avalanching nanoparticles via a discrete shift of threshold intensity mediated by internal defect-based colour centres.
- Changhwan Lee
- , Emma Z. Xu
- & P. James Schuck
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Correspondence |
Satellite imagery identifies deliberate attacks on hospitals
- Danielle N. Poole
- , Nathaniel A. Raymond
- & Kaveh Khoshnood
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News & Views |
Cocktails of tags enhance resolution of microscopy technique
A limit on the resolution of optical-microscopy techniques has been broken by using a mixture of tags to label copies of target molecules in a sample, opening the way to better views of molecular organization in cells.
- Alistair Curd
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Outlook |
Revealing vascular roadblocks in the brain
High-resolution imaging quickly identifies blood clots before they inflict major damage.
- Michael Eisenstein
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Article
| Open AccessÅngström-resolution fluorescence microscopy
The authors introduce a single-molecule DNA-barcoding method, resolution enhancement by sequential imaging, that improves the resolution of fluorescence microscopy down to the Ångström scale using off-the-shelf fluorescence microscopy hardware and reagents.
- Susanne C. M. Reinhardt
- , Luciano A. Masullo
- & Ralf Jungmann
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Editorial |
For chemists, the AI revolution has yet to happen
Machine-learning systems in chemistry need accurate and accessible training data. Until they get it, they won’t achieve their potential.
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Article
| Open AccessStructural basis of NINJ1-mediated plasma membrane rupture in cell death
Structural, biochemical and mutagenesis studies indicate that, in dying cells, the membrane protein NINJ1 assembles into filaments, disrupting the cell membrane.
- Morris Degen
- , José Carlos Santos
- & Sebastian Hiller
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News |
Deadly mushroom poison might now have an antidote — with help from CRISPR
Gene-editing technique might have finally cracked the mystery of how death cap mushrooms kill.
- Saima Sidik
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Technology Feature |
Brain imaging: fMRI advances make scans sharper and faster
Researchers are finding ways to improve one of neuroscientists’ favourite tools: functional magnetic resonance imaging.
- Diana Kwon
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News |
Lab-grown monkey embryos reveal in 3D how organs begin
At 25 days old, specimens could be the oldest primate embryos ever grown outside the womb.
- Gemma Conroy
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Research Briefing |
Detectors that encode angles of incoming light as colour
Most light-field sensors — devices that detect the angles of incoming light rays to reconstruct 3D scenes — can detect light only in the ultraviolet and visible wavelength ranges. A newly developed light-field sensor comprising perovskite nanocrystals encodes the angles of incoming visible-light beams and X-rays as different colours.
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Nature Podcast |
‘Pangenome’ aims to capture the breadth of human diversity
Mapping a more diverse human genome, and the latest from the Nature Briefing.
- Nick Petrić Howe
- & Shamini Bundell
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News |
New cellular ‘organelle’ discovered inside fruit-fly intestines
Fruit-fly cells use previously unknown complex cellular structures to store phosphate, a molecule essential to life
- Gemma Conroy
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News |
Huge cache of mammal genomes offers fresh insights on human evolution
The Zoonomia Project is helping to pinpoint genes responsible for animal-brain size and for human disease.
- Max Kozlov
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Editorial |
The gene-therapy revolution risks stalling if we don’t talk about drug pricing
Regulation and new intellectual property laws are needed to reduce the cost of gene-editing treatments and fulfil their promise to improve human health.
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News |
Comb jellies’ unique fused neurons challenge evolution ideas
Fused neurons suggest ctenophores’ nervous system evolved independently of that in other animals.
- Mariana Lenharo
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Technology Feature |
Every base everywhere all at once: pangenomics comes of age
Multi-genome assemblies called pangenomes can capture genetic diversity in a species, but researchers are still working out how best to build and explore them.
- Michael Eisenstein
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