Featured
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Article
| Open Access
A microfluidic transistor for automatic control of liquids
Flow limitation is exploited to develop a microfluidic device exhibiting flow–pressure behaviour analogous to the current–voltage characteristics of an electronic transistor.
- Kaustav A. Gopinathan
- , Avanish Mishra
- & Mehmet Toner
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Article
| Open Access
Single-cell quantification of ribosome occupancy in early mouse development
A single-cell ribosome profiling method can provide data at the level of allele-specific ribosome engagement in early development.
- Hakan Ozadam
- , Tori Tonn
- & Can Cenik
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Article |
Microfluidic chain reaction of structurally programmed capillary flow events
Microfluidic chain reactions encode programs structurally in situ, and can form a frugal, versatile, bona fide lab-on-a-chip with wide-ranging applications in liquid handling and point-of-care diagnostics
- Mohamed Yafia
- , Oriol Ymbern
- & David Juncker
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Article |
DNA mismatches reveal conformational penalties in protein–DNA recognition
A high-throughput assay that introduces mismatched base pairs into the DNA sequence shows that mismatches can increase transcription factor binding affinity by prepaying some of the energetic cost of distorting the DNA.
- Ariel Afek
- , Honglue Shi
- & Raluca Gordân
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Letter |
Self-coalescing flows in microfluidics for pulse-shaped delivery of reagents
Characterization of a capillary flow phenomenon termed self-coalescence leads to the development of scalable, compact microfluidic devices that could see application in diagnostics, high-throughput screening and biological assays.
- Onur Gökçe
- , Samuel Castonguay
- & Emmanuel Delamarche
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Letter |
Structural colour using organized microfibrillation in glassy polymer films
Standing-wave optics can be used to control microfibril and cavity formation in polymer films and the resulting porous layered structures can produce tunable structural colour, enabling inkless ‘printing’ of images.
- Masateru M. Ito
- , Andrew H. Gibbons
- & Easan Sivaniah
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Review Article |
The present and future role of microfluidics in biomedical research
Recent progress in the various lab-on-a-chip microtechnologies is reviewed and the clinical and research areas in which they have made the greatest impact are discussed.
- Eric K. Sackmann
- , Anna L. Fulton
- & David J. Beebe
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Research Highlights |
Shunting bacteria on a chip
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Technology Feature |
A living system on a chip
For years, scientists have struggled to reconstruct tissues and organs by combining cells and nanotechnology. These devices are now edging from cool concept to practical application.
- Monya Baker
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News |
Making lungs in the lab
Implanted tissue and microchip mimic both perform functions of lung.
- Alla Katsnelson
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Research Highlights |
Bioengineering: Cell culture on a chip
Digital colloid-enhanced Raman spectroscopy by single-molecule counting