Featured
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News |
This fMRI technique promised to transform brain research — why can no one replicate it?
The DIANA technique sparked excitement from neuroscientists. But two new papers have cast doubt over the results.
- McKenzie Prillaman
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Nature Video |
Building a heart atlas: researchers map organ in stunning detail
Cutting edge imaging techniques reveal how cells organise as the heart develops.
- Dan Fox
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Outlook |
Tracking down tuberculosis
Improvements in screening and diagnosis could help to eradicate this curable disease.
- Neil Savage
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Technology Feature |
AI under the microscope: the algorithms powering the search for cells
Deep learning is driving the rapid evolution of algorithms that can automatically find and trace cells in a wide range of microscopy experiments.
- Michael Eisenstein
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Nature Video |
The 3D printer that crafts complex robotic organs in a single run
Combining machine vision with contactless error correction allows for even more advanced multi-material printing.
- Dan Fox
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News & Views |
The deep route to low-field MRI with high potential
A type of magnetic resonance imaging, known as low-field MRI, could make the technique more widely accessible, but only if the image quality can be improved. A deep-learning protocol might hold the key.
- Patricia M. Johnson
- & Yvonne W. Lui
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News |
New explanation for infertility: eggs lacking a mysterious ‘lattice’
The discovery of a ‘storage locker’ for essential proteins could explain some cases of infertility.
- Gayathri Vaidyanathan
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Article
| Open Access
Neural signal propagation atlas of Caenorhabditis elegans
Measurements of signal propagation in more than 23,000 pairs of neurons from nematode worms show that predictions of neural function made on the basis of anatomy are often incorrect, in part owing to the effects of extrasynaptic signalling.
- Francesco Randi
- , Anuj K. Sharma
- & Andrew M. Leifer
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Technology Feature |
How open-source software could finally get the world’s microscopes speaking the same language
A plethora of standards mean shareable and verifiable microscopy data often get lost in translation. Biologists are working on a solution.
- Michael Brooks
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News Q&A |
UFO sightings: how NASA can bring science to the debate
An astrophysicist who advised the agency talks to Nature about ways to bring rigour to reports of ‘unidentified anomalous phenomena’.
- Alexandra Witze
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Technology Feature |
The quest to map the mouse brain
By combining single-cell sequencing with methods to map the spatial location of gene expression, scientists are unravelling the extraordinary cellular diversity of the brain.
- Diana Kwon
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Technology Feature |
Sharp resolution, big samples: ExA-SPIM microscope accelerates brain imaging
An innovative microscopy technique bridges the gap between field of view and resolution.
- Alla Katsnelson
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Book Review |
Anna Atkins: pioneering botanical photographer who captured algae and ferns in ghostly blue images
A compilation of 550 original plates reveals the dedicated work of the nineteenth-century woman who was the first to publish a book with cyanotypes of specimens.
- Georgina Ferry
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Article |
High-throughput Oligopaint screen identifies druggable 3D genome regulators
High-throughput DNA or RNA labelling with optimized Oligopaints (HiDRO) reveals more than 300 factors that influence genome folding during interphase, including 43 genes that were validated as either increasing or decreasing interactions between topologically associating domains.
- Daniel S. Park
- , Son C. Nguyen
- & Eric F. Joyce
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News |
Developing human embryos imaged at highest-ever resolution
Non-invasive imaging approach could lead to innovations in embryo screening.
- Miryam Naddaf
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Correspondence |
Satellite imagery identifies deliberate attacks on hospitals
- Danielle N. Poole
- , Nathaniel A. Raymond
- & Kaveh Khoshnood
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Outlook |
Revealing vascular roadblocks in the brain
High-resolution imaging quickly identifies blood clots before they inflict major damage.
- Michael Eisenstein
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News & Views |
Cocktails of tags enhance resolution of microscopy technique
A limit on the resolution of optical-microscopy techniques has been broken by using a mixture of tags to label copies of target molecules in a sample, opening the way to better views of molecular organization in cells.
- Alistair Curd
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Technology Feature |
Brain imaging: fMRI advances make scans sharper and faster
Researchers are finding ways to improve one of neuroscientists’ favourite tools: functional magnetic resonance imaging.
- Diana Kwon
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Research Briefing |
Detectors that encode angles of incoming light as colour
Most light-field sensors — devices that detect the angles of incoming light rays to reconstruct 3D scenes — can detect light only in the ultraviolet and visible wavelength ranges. A newly developed light-field sensor comprising perovskite nanocrystals encodes the angles of incoming visible-light beams and X-rays as different colours.
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News |
New cellular ‘organelle’ discovered inside fruit-fly intestines
Fruit-fly cells use previously unknown complex cellular structures to store phosphate, a molecule essential to life
- Gemma Conroy
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Research Briefing |
Diversity of mitochondrial networks in lung cancer imaged
The structure and function of mitochondrial networks were analysed using a combination of approaches to generate detailed maps of these cellular organelles. This analysis revealed that the mitochondria in different subtypes of lung cancer show distinct functional and structural signatures.
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News & Views |
From the archive: machine intelligence, and the father of X-rays
Snippets from Nature’s past.
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Technology Feature |
Smart microscopes spot fleeting biology
Automated microscopes that adapt to each sample’s quirks can capture elusive biological phenomena at high resolution.
- Jyoti Madhusoodanan
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Research Briefing |
A wearable ultrasound patch for continuous heart imaging
A new ultrasound patch can image the heart while being worn, even when the wearer is moving during strenuous exercise. A customized model that uses a technique of artificial intelligence called deep learning then processes the images to extract important measures of cardiac performance.
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Research Briefing |
Structural landscape inside cells mapped in detail
More than 200,000 human stem cells were imaged at high resolution and in 3D to make a reference data set that was used to create a generalizable computational framework. This enables cell shapes and the locations of internal structures to be measured and compared using rigorous statistical methods.
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Article |
Locomotion activates PKA through dopamine and adenosine in striatal neurons
Dopamine and adenosine act together in the striatum to regulate protein kinase A activity, which in turn coordinates animal locomotion.
- Lei Ma
- , Julian Day-Cooney
- & Haining Zhong
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News |
Faster MRI scan captures brain activity in mice
Improved technique could provide fine-scale insights into how brain regions communicate.
- McKenzie Prillaman
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Outlook |
Your brain on psychedelics
Mind-altering drugs are shaking up medicine — but how they actually work remains a mystery. A flurry of imaging studies could clarify the picture.
- Liam Drew
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News & Views |
From the archive: ancient poisonous honey, and museum photography
Snippets from Nature’s past.
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Technology Feature |
Five ways deep learning has transformed image analysis
From connectomics to behavioural biology, artificial intelligence is making it faster and easier to extract information from images.
- Sandeep Ravindran
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Outlook |
How to improve the diagnosis of prostate cancer
Prostate-specific antigen is an established biomarker, but it is flawed. Research into alternatives is starting to get results, but will they reduce mortality?
- Benjamin Plackett
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Outlook |
Metastatic prostate cancer: seeking a fresh chance of recovery
Advances in the ability to find and treat tumours that have spread around the body are changing the perception of what is possible for people with advanced disease.
- Charlie Schmidt
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Outlook |
A better way to biopsy in prostate cancer
Imaging and advanced tissue sampling techniques could supplement or supersede conventional biopsies of the sensitive gland.
- Michael Eisenstein
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Research Highlight |
A diamond sensor shines at ‘seeing’ voltages
Crystalline device could be used to visualize voltages with high resolution, speed and stability.
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Where I Work |
Diving into deep-tissue imaging to help with cancer research
Leonel Malacrida hopes that his lab’s imaging technology will advance cancer diagnosis and research in Uruguay and across Latin America.
- Patricia Maia Noronha
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Article
| Open Access
Spatial profiling of chromatin accessibility in mouse and human tissues
Spatial-ATAC-seq—spatially resolved chromatin accessibility profiling of tissue sections using next-generation sequencing—delineated tissue-region-specific epigenetic landscapes in mouse embryos and identified gene regulators involved in the development of the central nervous system and the lymphoid tissue.
- Yanxiang Deng
- , Marek Bartosovic
- & Rong Fan
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Technology Feature |
How to make spatial maps of gene activity — down to the cellular level
Computational and experimental methods are bringing researchers closer to their goal of revealing exactly where in a cell or tissue each gene is expressed.
- Michael Eisenstein
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Nature Video |
Lasers reveal ancient pyramids and canals hidden in the Amazon
Hundreds of new archaeological sites have been discovered beneath the trees.
- Shamini Bundell
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News & Views |
From the archive: Jamaican coral reefs, and indispensable photography
Snippets from Nature’s past.
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Article |
Transcriptional coupling of distant regulatory genes in living embryos
In Drosophila, there are extensive physical and functional associations of distant paralogous genes, including co-regulation by shared enhancers and co-transcriptional initiation over distances of nearly 250 kilobases.
- Michal Levo
- , João Raimundo
- & Michael S. Levine
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News |
Your brain expands and shrinks over time — these charts show how
Based on more than 120,000 brain scans, the charts are still preliminary. But researchers hope they could one day be used as a routine clinical tool by physicians.
- Max Kozlov
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Correspondence |
Secure molybdenum isotope supplies for diagnostics
- Antonino Pietropaolo
- , Marco Capogni
- & Lina Quintieri
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Article |
Regulation of liver subcellular architecture controls metabolic homeostasis
Detailed reconstruction using enhanced focused ion beam scanning electron microscopy imaging and deep-learning-based automated segmentation demonstrates that hepatocyte subcellular organelle architecture regulates metabolism.
- Güneş Parlakgül
- , Ana Paula Arruda
- & Gökhan S. Hotamışlıgil
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Research Highlight |
Soft X-rays capture the dance of the organelles
A CT-like scan images what’s inside a live cell in 3D — including the interactions of its components.
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News & Views |
From the archive
Nature’s pages feature the discovery of a key defence response, and a collection of items from an inventor highlights developments in photography.
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Technology Feature |
Python power-up: new image tool visualizes complex data
The image viewing and analysis software napari has filled a gap in the programming language’s scientific ecosystem.
- Jeffrey M. Perkel
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Article |
Multiview confocal super-resolution microscopy
A combination of multiview imaging, structured illumination, reconstruction algorithms and deep-learning predictions realizes spatial- and temporal-resolution improvements in fluorescence microscopy to produce super-resolution images from diffraction-limited input images.
- Yicong Wu
- , Xiaofei Han
- & Hari Shroff
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Research Highlight |
Brightest X-rays on Earth expose COVID lung damage
Imaging technique can pick up micrometre-scale details of intact brains and other organs.
A milestone map of mouse-brain connectivity reveals challenging new terrain for scientistsBrowse broader subjects
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