Behavioural methods articles within Nature

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  • Letter |

    Mammals are repelled by large concentrations of salts but attracted to low concentrations of sodium. In mice, the latter behaviour can be blocked by the ion channel inhibitor amiloride. Here, mice have been produced lacking the drug's target sodium channel, ENaC, specifically in taste receptor neurons. It is confirmed that sodium sensing, like the four other taste modalities (sweet, sour, bitter and umami), is mediated by a dedicated 'labelled line'.

    • Jayaram Chandrashekar
    • , Christina Kuhn
    •  & Charles S. Zuker